https://m2.mtmt.hu/ hun 2026-05-01 17:07 JournalArticle 1482607 VALIDATED true Megjegyzés-21984369 : FN Thomson Reuters Web of Knowledge Z9: 1 Megjegyzés-21984223 Z9: 1 0 2014-09-10T13:12:45.000+0000 false 1482607 2025-12-20T22:08:54.970+0000 2018-10-11T11:05:05.782+0000 2011-03-21T13:09:58.000+0000 true 10018476 Magyar Attila /api/author/10018476 Author true 10018476 2014-09-10T13:12:45.000+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 2014-09-10T13:12:45.000+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kabell, S Impact of heterophil granulocyte depletion caused by 5-fluorouracil on infectious bursal disease virus infection in specific pathogen free chickens true true /api/journal/604 REVIEWED true false 604 false 604 true 0307-9457 1465-3338 Journal FOREIGN 35 4 341 348 341 8 2006 The purpose of this study was to investigate the influence of the cytostatic drug, 5-fluorouracil (5-FU), which causes depletion of heterophil granulocytes, on clinical symptoms and histological lesions during the progress of infectious bursal disease virus (IBDV) infection in chickens. The aim was to disclose the mechanism behind the clinical disease symptoms. Three groups of specific pathogen free chickens were used for the experiment. Chickens in groups 1 and 3 were pretreated with 5-FU, while chickens in group 2 were treated with a placebo. After 5 days, the chickens in groups 2 and 3 were inoculated with the classical IBDV strain F52/70. Bursae of Fabricius were sampled at fixed intervals, and the progress of the infection was monitored by various histological techniques and reverse transcriptase-polymerase chain reaction (RT-PCR). We found correlation between histological observations and RT-PCR results. In the 5-FU pretreated chickens, IBDV caused only mild clinical symptoms, even though histological alterations similar to alterations caused by IBDV were still observed. The 5-FU pretreatment resulted in severe heterophil granulocyte depletion by days 2 and 3 after infection (post inoculation) and increased numbers of bursal secretory dendritic cells in the medulla of the follicles. IBDV infection seemed to induce fusion of secretory dendritic cells, resulting in formation of multinucleated giant cells, loaded with apoptotic B cells and virus particles associated with granules of bursal secretory dendritic cells. Our results indicate that the heterophil granulocytes together with the bursal secretory dendritic cells contribute to the outbreak and/or progress of clinical symptoms. 2011 true true true false true false NONE 2025-12-20 false true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 11 0 11 7 4 11 11 11 6 11 11 7 7 7 4 0 11 7 11 7 0 7 7 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2011 0 1 0 1 0 2012 0 0 0 0 0 2013 0 0 0 0 0 2014 0 0 0 0 0 2015 0 1 1 1 1 2016 0 2 2 2 2 2017 0 0 0 0 0 2018 0 0 0 0 0 2019 0 0 0 0 0 2020 0 2 2 2 2 2021 0 0 0 0 0 2022 0 1 0 1 0 2023 0 1 0 1 0 2024 0 2 1 2 1 2025 0 1 1 1 1 D1 false false false false 2014-09-10T13:12:45.000+0000 2013-02-23T19:18:00.000+0000 Humánmorfológiai és Fejlődésbiológiai Intézet (SE / AOK / I) 2 9 1 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 1450721 /api/authorship/1450721 1 0.14285715 true false Kabell S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11981338 true PersonAuthorship 1450722 /api/authorship/1450722 2 0.14285715 false false Igyarto BZ true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11981337 true PersonAuthorship 1450723 /api/authorship/1450723 3 0.14285715 false false Author 10018476 /api/author/10018476 Magyar Attila true 10018476 true Magyar A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11981336 true PersonAuthorship 1450724 /api/authorship/1450724 4 0.14285715 false false Hajdu Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11981335 true PersonAuthorship 1450725 /api/authorship/1450725 5 0.14285715 false false Biro E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11981334 true PersonAuthorship 1450726 /api/authorship/1450726 6 0.14285715 false false Bisgaard M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11981333 true PersonAuthorship 1450727 /api/authorship/1450727 7 0.14285715 false true Author 10005243 /api/author/10005243 Oláh Imre true 10005243 true Olah I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11981332 true PublicationIdentifier 356048 /api/publicationidentifier/356048 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1080/03079450600821141 https://doi.org/10.1080/03079450600821141 false 946050 true PublicationIdentifier 356046 /api/publicationidentifier/356046 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000239165900014 https://www.webofscience.com/wos/woscc/full-record/000239165900014 false 946049 true PublicationIdentifier 356047 /api/publicationidentifier/356047 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 33746603140 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-33746603140 false 946051 true PublicationIdentifier 356049 /api/publicationidentifier/356049 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 16854650 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16854650&dopt=Abstract false 202704 true Classification 12682 /api/classification/12682 true true Classification 12656 /api/classification/12656 true true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Keyword 12 /api/keyword/12 true 12 true Keyword 1030274 /api/keyword/1030274 true 1030274 true Keyword 1039928 /api/keyword/1039928 true 1039928 true Keyword 1039929 /api/keyword/1039929 true 1039929 true Keyword 1039930 /api/keyword/1039930 true 1039930 true Keyword 1039931 /api/keyword/1039931 true 1039931 true Keyword 1039932 /api/keyword/1039932 true 1039932 true Keyword 1039945 /api/keyword/1039945 true 1039945 true SjrRating 5907871 /api/sjrrating/5907871 23 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1103 /api/classificationexternal/1103 true 1103 true D1 DIRECT true 5907871 true /api/publication/1482607 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Kabell S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Igyarto BZ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018476"><a href="/gui2/?type=authors&mode=browse&sel=10018476" target="_blank">Magyar A (<span class="authorship-author-name">Magyar Attila</span> <span class="authorAux-mtmt"> fejlődésbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Humánmorfológiai és Fejlődésbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hajdu Z </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Biro E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bisgaard M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10005243"><a href="/gui2/?type=authors&mode=browse&sel=10005243" target="_blank">Olah I (<span class="authorship-author-name">Oláh Imre</span> <span class="authorAux-mtmt"> Immunológia - histológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Humánmorfológiai és Fejlődésbiológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1482607" target="_blank">Impact of heterophil granulocyte depletion caused by 5-fluorouracil on infectious bursal disease virus infection in specific pathogen free chickens</a></div> <div> <span class="journal-title">AVIAN PATHOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0307-9457">0307-9457</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1465-3338">1465-3338</a>)</span>: <span class="journal-volume">35</span> <span class="journal-issue">4</span> <span class="page"> pp 341-348 </span> <span class="year">(2006)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1080/03079450600821141" target="_blank" href="https://doi.org/10.1080/03079450600821141"> DOI </a> </span> <span class="id 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Scopus - Immunology and Microbiology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 7 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt:&nbsp;6 | WoS/Scopus jelölt:&nbsp;11 | DOI jelölt:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1482607&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1482607</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 1482607</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2018.10.11. 13:05 WoS import (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megjegyzés-21984369 : FN Thomson Reuters Web of Knowledge Z9: 1 Megjegyzés-21984223 Z9: 1</pre> </div></div>