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Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K(+) channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10018833"> <a href="/gui2/?type=authors&mode=browse&sel=10018833" target="_blank">Szabadfi, K</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Mester, L </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001467"> <a href="/gui2/?type=authors&mode=browse&sel=10001467" target="_blank">Reglodi, D</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10016515"> <a href="/gui2/?type=authors&mode=browse&sel=10016515" target="_blank">Kiss, P</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Babai, N </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10013626"> <a href="/gui2/?type=authors&mode=browse&sel=10013626" target="_blank">Racz, B</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10014558"> <a href="/gui2/?type=authors&mode=browse&sel=10014558" target="_blank">Kovacs, K</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10016688"> <a href="/gui2/?type=authors&mode=browse&sel=10016688" target="_blank">Szabo, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10013006"> <a href="/gui2/?type=authors&mode=browse&sel=10013006" target="_blank">Tamas, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10008988"> <a href="/gui2/?type=authors&mode=browse&sel=10008988" target="_blank">Gabriel, R</a> </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1433543" mtid="1433543" target="_blank">Novel neuroprotective strategies in ischemic retinal lesions</a></div> <div class="pub-info"> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-volume">11</span> : <span class="journal-issue">2</span> <span class="page"> pp. 544-561. , 18 p. </span> <span class="year">(2010)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms11020544" target="_blank" href="https://doi.org/10.3390/ijms11020544"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000274973500010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000274973500010"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="77649211292" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-77649211292"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="20386654" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20386654&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="7435540638862503800" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=7435540638862503800"> Google scholar </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:1433543 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Összefoglaló cikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 35</span> | Független: 19 | Függő: 16 | Nem jelölt: 0 | WoS jelölt: 29 | Scopus jelölt: 29 | WoS/Scopus jelölt: 30 | DOI jelölt: 30 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10018833"><a href="/gui2/?type=authors&mode=browse&sel=10018833" target="_blank">Szabadfi K (<span class="authorship-author-name">Szabadfi Krisztina</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">BI</span>/Kisérletes Állattani és Neurobiológiai Tanszék</span> ; <span class="author-name" >Mester L </span> ; <span class="author-name" mtid="10001467"><a href="/gui2/?type=authors&mode=browse&sel=10001467" target="_blank">Reglodi D (<span class="authorship-author-name">Reglődi Dóra</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Anatómiai Intézet</span> ; <span class="author-name" mtid="10016515"><a href="/gui2/?type=authors&mode=browse&sel=10016515" target="_blank">Kiss P (<span class="authorship-author-name">Kiss Péter</span> <span class="authorAux-mtmt"> Neuroanatómia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Anatómiai Intézet</span> ; <span class="author-name" >Babai N </span> ; <span class="author-name" mtid="10013626"><a href="/gui2/?type=authors&mode=browse&sel=10013626" target="_blank">Racz B (<span class="authorship-author-name">Rácz Boglárka</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai és Orvosi Kémiai Intézet</span> ; 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<span class="author-name" mtid="10008988"><a href="/gui2/?type=authors&mode=browse&sel=10008988" target="_blank">Gabriel R (<span class="authorship-author-name">Gábriel Róbert</span> <span class="authorAux-mtmt"> Biológiai tudományok</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">BI</span>/Kisérletes Állattani és Neurobiológiai Tanszék</span> ; <span class="author-name" mtid="10016921"><a href="/gui2/?type=authors&mode=browse&sel=10016921" target="_blank">Atlasz T (<span class="authorship-author-name">Atlasz Tamás</span> <span class="authorAux-mtmt"> Biológia tudományok</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Sporttudományi és Testnevelési Intézet">STI</span>/Sportbiológia Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;1433543" target="_blank">Novel neuroprotective strategies in ischemic retinal lesions</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">2</span> <span class="page"> pp 544-561 </span> <span class="year">(2010)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms11020544" target="_blank" href="https://doi.org/10.3390/ijms11020544"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000274973500010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000274973500010"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="77649211292" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-77649211292"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="20386654" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20386654&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="7435540638862503800" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=7435540638862503800"> Google scholar </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 35</span> | Független: 19 | Függő: 16 | Nem jelölt: 0 | WoS jelölt: 29 | Scopus jelölt: 29 | WoS/Scopus jelölt: 30 | DOI jelölt: 30 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1433543&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 31 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1433543</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> <span class="oldId">Régi azonosító: 1433543</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2023.11.21. 22:37 Pécsi Éva (MTMT Közp 3, admin) </div> <div class="lockedBy">Ideiglenesen zárolva 2023.11.07. 10:01 Pécsi Éva (MTMT Közp 3, admin) </div> </div></div>