Inhibitor sensitivity of human serum and vascular semicarbazide-sensitive amine oxidases

https://m2.mtmt.hu/ hun 2026-10-23 11:41 JournalArticle 1431249 ADMIN_APPROVED true Cited By :6 Export Date: 7 September 2020 CODEN: NROBE Correspondence Address: Meszaros, Zs.; Department of Pharmacodynamics, Semmelweis University of Medicine, Nagyvarad ter 4, H-1089 Budapest, Hungary Cited By :6 Export Date: 26 July 2021 CODEN: NROBE Correspondence Address: Meszaros, Zs.; Department of Pharmacodynamics, Nagyvarad ter 4, H-1089 Budapest, Hungary 0 2018-09-12T12:11:39.000+0000 false 1431249 2025-09-24T08:27:51.421+0000 2025-07-01T23:11:31.055+0000 2011-02-02T15:22:51.000+0000 true 10000449 Karádi István /api/author/10000449 Author Karádi István (Endokrinológia) true 10000449 2025-07-01T23:11:31.224+0000 2025-07-01T23:11:31.224+0000 2011-04-07T00:52:14.000+0000 true 10003134 Wolf György /api/admin/10003134 Admin Wolf György (MTMT Központi admin) true 10003134 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Meszaros, Zs Inhibitor sensitivity of human serum and vascular semicarbazide-sensitive amine oxidases true false /api/journal/1209683 REVIEWED NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES 1216-8068 true true 1209683 false 1209683 true 1216-8068 Journal FOREIGN 8 2 215 223 215 9 2000 Recent data suggest that elevated serum semicarbazide-sensitive amine oxidase activity (SSAO) may cause endothelial injury. Formation of cytotoxic metabolites (especially formaldehyde) and increased oxidative stress might lead to initiation or progression of atherosclerosis. Effective and selective inhibitors of human SSAO might exert cytoprotective effect on endothelial cells. To compare the inhibitor sensitivity of human serum and vascular tissue SSAO enzyme, the inhibitory effect of semicarbazide and MDL 72974A was investigated. Serum and vascular SSAO activity has been determined using <sup>14</sup>C-benzylamine as a substrate. The IC<sub>50</sub> values of semicarbazide were estimated to be 5x10<sup>-3</sup>M and 5x10<sup>-4</sup>M for SSAO from human serum and saphenous vein, respectively. MDL 72974A amine oxidase inhibitor was more than thousand times more effective than semicarbazide. The IC<sub>50</sub> values were 10<sup>-7</sup>M and 10<sup>-8</sup>M for SSAO from human serum and saphenous vein, respectively. This finding supports the hypothesis that soluble and membrane-bound vascular SSAO enzymes might have similar structure. 2011 false true true false true false NONE 2025-09-24 false 6 0 6 2 3 5 4 4 6 6 6 2 2 2 4 0 6 2 6 2 0 1 1 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2001 0 1 0 1 0 2002 0 1 0 1 0 2003 0 0 0 0 0 2004 0 2 1 2 1 2005 0 0 0 0 0 2006 0 2 1 2 1 Q4 false false false false 2011-04-07T00:52:14.000+0000 2013-02-23T19:18:00.000+0000 Akadémikus bibliográfia; III. Sz. Belgyógyászati Klinika (SE / AOK / K); MTA-SE Neurokémiai Kutatócsoport (2007-től társ... (MTA TKI); Széchenyi István Egyetem 4 31 4 6 0 false Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 1322406 /api/authorship/1322406 Meszaros, Zs [Mészáros, Zsuzsa (Neurokémia), szerző] MTA-SE Neurokémiai Kutatócsoport (2007-től társ... (MTA TKI) 1 0.16666667 true false Author 10015560 /api/author/10015560 Mészáros Zsuzsa (Neurokémia) Mészáros Zsuzsa false 10015560 true Meszaros Zs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11707672 true PersonAuthorship 1322407 /api/authorship/1322407 Csanyi, A [Csányi, Attila (Neurológia, strok...), szerző] Széchenyi István Egyetem 2 0.16666667 false false Author 10011385 /api/author/10011385 Csányi Attila (Neurológia, stroke, neurosonologia, elektrofiziológia) Csányi Attila true 10011385 true Csanyi A true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11707671 true PersonAuthorship 1322408 /api/authorship/1322408 Vallus, G 3 0.16666667 false false Vallus G true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11707670 true PersonAuthorship 1322409 /api/authorship/1322409 Szombathy, T 4 0.16666667 false false Szombathy T true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11707669 true PersonAuthorship 1322410 /api/authorship/1322410 Karadi, I [Karádi, István (Endokrinológia), szerző] III. Sz. Belgyógyászati Klinika (SE / AOK / K) 5 0.16666667 false false Author 10000449 /api/author/10000449 Karádi István (Endokrinológia) Karádi István true 10000449 true Karadi I true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11707668 true PersonAuthorship 1322411 /api/authorship/1322411 Magyar, K [Magyar, Kálmán (Központi idegrend...), szerző] MTA-SE Neurokémiai Kutatócsoport (2007-től társ... (MTA TKI) 6 0.16666667 false true Author 10000973 /api/author/10000973 Magyar Kálmán (Központi idegrendszer farmakobiokémiája) Magyar Kálmán true 10000973 true Magyar K true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11707667 true Institute 19040 /api/institute/19040 Akadémikus bibliográfia [2016-] 0 false false true Akadémikus bibliográfia Bibliografy of Hungarian of Academy of Sciences' academicians true 19040 true PublicationIdentifier 329798 /api/publicationidentifier/329798 Scopus: 0033770434 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 0033770434 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0033770434 false 183461 true PublicationIdentifier 329799 /api/publicationidentifier/329799 PubMed: 11061216 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 11061216 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11061216&dopt=Abstract false 183462 true Classification 12125 /api/classification/12125 Általános orvostudomány true true Keyword 308 /api/keyword/308 ATHEROSCLEROSIS true 308 true Keyword 357 /api/keyword/357 SERUM true 357 true Keyword 1699 /api/keyword/1699 ARTICLE true 1699 true Keyword 3122 /api/keyword/3122 human true 3122 true Keyword 4608 /api/keyword/4608 controlled study true 4608 true Keyword 5486 /api/keyword/5486 Support, Non-U.S. Gov't true 5486 true Keyword 5883 /api/keyword/5883 clinical article true 5883 true Keyword 6666 /api/keyword/6666 enzyme activity true 6666 true Keyword 6683 /api/keyword/6683 enzyme inhibition true 6683 true Keyword 10949 /api/keyword/10949 Solubility true 10949 true Keyword 14048 /api/keyword/14048 Diabetic Angiopathies true 14048 true Keyword 14679 /api/keyword/14679 human tissue true 14679 true Keyword 15204 /api/keyword/15204 Arteriosclerosis true 15204 true Keyword 18894 /api/keyword/18894 benzylamine true 18894 true Keyword 1000442 /api/keyword/1000442 Monoamine oxidase true 1000442 true Keyword 1009205 /api/keyword/1009205 cell protection true 1009205 true Keyword 1009294 /api/keyword/1009294 Muscle, Smooth, Vascular true 1009294 true Keyword 1009539 /api/keyword/1009539 varicosis true 1009539 true Keyword 1009569 /api/keyword/1009569 Monoamine Oxidase Inhibitors true 1009569 true Keyword 1019671 /api/keyword/1019671 Endothelium, Vascular true 1019671 true Keyword 1019672 /api/keyword/1019672 Diabetes Mellitus, Non-Insulin-Dependent true 1019672 true Keyword 1019673 /api/keyword/1019673 Butylamines true 1019673 true Keyword 1019674 /api/keyword/1019674 Allyl Compounds true 1019674 true Keyword 1019675 /api/keyword/1019675 saphenous vein true 1019675 true Keyword 1019676 /api/keyword/1019676 endothelium injury true 1019676 true Keyword 1019677 /api/keyword/1019677 mofegiline true 1019677 true Keyword 1019678 /api/keyword/1019678 Smooth muscle true 1019678 true Keyword 1019679 /api/keyword/1019679 Semicarbazide true 1019679 true Keyword 1019680 /api/keyword/1019680 Amine oxidase true 1019680 true Keyword 1019696 /api/keyword/1019696 Amine Oxidase (Copper-Containing) true 1019696 true Keyword 1019700 /api/keyword/1019700 amine oxidase (copper containing) true 1019700 true Keyword 2014641 /api/keyword/2014641 Oxidative stress true true SjrRating 6150610 /api/sjrrating/6150610 sjr:Q4 (2000) Scopus - Neuroscience (miscellaneous) NEUROBIOLOGY - BUDAPEST 1216-8068 81 1.0 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 Scopus - Neuroscience (miscellaneous) true 2801 true Q4 DIRECT true 6150610 true Reference 1211088 /api/reference/1211088 1. Banchelli, G., Bertocci, B., Buffoni, F., A selective inhibitor of plasma benzylamine oxidase and of tissue semicarbazide-sensitive amine oxidases (SSAO) (1988) Pharmacol. Res. Commun., 20 (SUPPL. 4), p. 165 1 false true Reference 1211089 /api/reference/1211089 2. Boomsma, F., Derkx, F.H.M., Van den Meiracker, A.H., Man in 't Veld, A.J., Schalekamp, M.A., Plasma semicarbazide-sensitive amine oxidase activity is elevated in diabetes mellitus and correlates with glycosylated haemoglobin (1995) Clin. Sci., 88 (6), pp. 675-679 2 false true Reference 1211090 /api/reference/1211090 3. Boomsma, F., Van Veldhuisen, D.J., De Kam, P.J., Man in 't Veld, A.J., Mosterd, A., Lie, K.I., Schalekamp, M.A., Plasma semicarbazide-sensitive amine oxidase is elevated in patients with congestive heart failure (1997) Cardiovasc. Res., 33 (2), pp. 387-391 3 false true Reference 1211091 /api/reference/1211091 4. Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye-binding (1976) Anal. Biochem., 72, pp. 248-254 4 false true Reference 1211092 /api/reference/1211092 5. Buffoni, F., Blaschko, H., Benzylamine oxidase and histaminase: Purification and crystallization of an enzyme from pig plasma (1964) Proceedings of the Royal Society B, 161, pp. 153-167 5 false true Reference 1211093 /api/reference/1211093 6. Cohen, M.L., Landry, A.S., Hemrick, S.K., Fuller, R.W., Norepinephrine, monoamine oxidase, and acetylcholinesterase in the rat jugular vein compared with other blood vessels (1979) Can. J. Physiol. Pharmacol., 57 (11), pp. 1246-1250 6 false true Reference 1211094 /api/reference/1211094 7. Figueiredo, I.V., Martinez Coscolla, A., Cotrim, M.D., Caramona, M.M., Callingham, B.A., Monoamine oxidase activities in human cystic and colonic arteries - Influence of age (1998) J. Neural. Transm., 52 (SUPPL.), pp. 217-223 7 false true Reference 1211095 /api/reference/1211095 8. Hysmith, R.M., Boor, P.J., Role of benzylamine oxidase in the cytotoxicity of allylamine toward aortic smooth muscle cells (1988) Toxicology, 51, pp. 133-145 8 false true Reference 1211096 /api/reference/1211096 9. Levinsohn, R., Copper containing amine oxidases in human disease (1988) Pharmacological Res. Commun., 20 (SUPPL. IV), pp. 45-49 9 false true Reference 1211097 /api/reference/1211097 10. Lyles, G.A., Mammalian plasma and tissue-bound semicarbazide-sensitive amine oxidases: Biochemical, pharmacological and toxicological aspects (1996) Int. J. Biochem. Cell Biol., 28 (3), pp. 259-274 10 false true Reference 1211098 /api/reference/1211098 11. Lyles, G.A., Chalmers, J., The metabolism of aminoacetone to methylglyoxal by semicarbazide-sensitive amine oxidase in human umbilical artery (1992) Biochem. Pharmacol., 43 (7), pp. 1409-1414 11 false true Reference 1211099 /api/reference/1211099 12. Lyles, G.A., Holt, A., Marshall, C.M.S., Further studies on the metabolism of methylamine by semicarbazide-sensitive amine oxidase activities in human plasma, umbilical artery and rat aorta (1990) J. Pharm. Pharmacol., 42, pp. 322-338 12 false true Reference 1211100 /api/reference/1211100 13. Meszaros, Z., Szombathy, T., Raimondi, L., Karadi, I., Romics, L., Magyar, K., Elevated serum semicarbazide-sensitive amine oxidase activity in non-insulin-dependent diabetes mellitus: Correlation with body mass index and serum triglyceride (1999) Metabolism, 48 (1), pp. 1-6 13 false true Reference 1211101 /api/reference/1211101 14. Osswald, W., Oxidative deamination of noradrenaline in human blood vessels (1990) J. Neural. Transm., 32 (SUPPL.), pp. 395-404 14 false true Reference 1211102 /api/reference/1211102 15. Smith, D., Salmi, M., Bono, P., Hellman, J., Leu, T., Jalkanen, S., Cloning of Vascular Adhesion Protein 1 reveals a novel multifunctional adhesion molecule (1998) J. Exp. Med., 188 (1), pp. 1-11 15 false true Reference 1211103 /api/reference/1211103 16. Vanhoutte, P.M., 5-hydroxytryptamine and vascular disease (1983) Federation Proceedings, 42 (2), pp. 233-237 16 false true Reference 1211104 /api/reference/1211104 17. Watanabe, K., Kobayashi, S., Oguchi, K., Microdetermination of human platelet MAO activity (1990) Showa Med. Lett., 44 (2), pp. 205-211 17 false true Reference 1211105 /api/reference/1211105 18. Yu, P.H., Lai, C.T., Zuo, D.M., Formation of formaldehyde from adrenaline in vivo; a potential risk factor for stress-related angiopathy (1997) Neurochem. Res., 22 (5), pp. 615-620 18 false true Reference 1211106 /api/reference/1211106 19. Yu, P.H., Zuo, D.M., Formaldehyde produced endogenously via deamination of methylamine. A potential risk factor for initiation of endothelial injury (1996) Atherosclerosis, 120, pp. 189-197 19 false true Reference 1211107 /api/reference/1211107 20. Yu, P.H., Zuo, D.M., Oxidative deamination of methylamine by semicarbazide-sensitive amine oxidase leads to cytotoxic damage in endothelial cells - Possible consequences for diabetes (1993) Diabetes, 42, pp. 594-603 20 false true Reference 1211108 /api/reference/1211108 21. Yu, P.H., Zuo, D.M., Inhibition of a type B monoamine oxidase inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine (MDL-72974A), on semicarbazide-sensitive amine oxidases isolated from vascular tissues and sera of different species (1992) Biochem. Pharmacol., 43 (2), pp. 307-312 21 false true Reference 1211109 /api/reference/1211109 22. Zreika, M., Fozard, J.R., Dudley, M.W., Bey, P., McDonald, I.A., Palfreyman, M.G., MDL 72974; a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson's disease (1989) J. Neural. Transm., 1 (PD Sect), pp. 243-254 22 false true /api/publication/1431249 Meszaros Zs et al. Inhibitor sensitivity of human serum and vascular semicarbazide-sensitive amine oxidases. (2000) NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES 1216-8068 8 2 215-223<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10015560"><a href="/gui2/?type=authors&mode=browse&sel=10015560" target="_blank">Meszaros Zs (<span class="authorship-author-name">Mészáros Zsuzsa</span> <span class="authorAux-mtmt"> Neurokémia</span>) </a> </span> <span class="author-affil"><span title="MTA Támogatott Kutatócsoportok">MTA TKI</span>/MTA-SE Neurokémiai Kutatócsoport (2007-től társult tag)</span> ;    <span class="author-name" mtid="10011385"><a href="/gui2/?type=authors&mode=browse&sel=10011385" target="_blank">Csanyi A (<span class="authorship-author-name">Csányi Attila</span> <span class="authorAux-mtmt"> Neurológia, stroke, neurosonologia, elektrofizi...</span>) </a> </span> <span class="author-affil">Széchenyi István Egyetem</span> ;    <span class="author-name" >Vallus G </span> ;    <span class="author-name" >Szombathy T </span> ;    <span class="author-name" mtid="10000449"><a href="/gui2/?type=authors&mode=browse&sel=10000449" target="_blank">Karadi I (<span class="authorship-author-name">Karádi István</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika</span> ;    <span class="author-name" mtid="10000973"><a href="/gui2/?type=authors&mode=browse&sel=10000973" target="_blank">Magyar K (<span class="authorship-author-name">Magyar Kálmán</span> <span class="authorAux-mtmt"> Központi idegrendszer farmakobiokémiája</span>) </a> </span> <span class="author-affil"><span title="MTA Támogatott Kutatócsoportok">MTA TKI</span>/MTA-SE Neurokémiai Kutatócsoport (2007-től társult tag)</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1431249" target="_blank">Inhibitor sensitivity of human serum and vascular semicarbazide-sensitive amine oxidases</a></div> <div> <span class="journal-title">NEUROBIOLOGY - AN INTERNATIONAL MULTIDISCIPLINARY JOURNAL IN NEUROSCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1216-8068">1216-8068</a> )</span>: <span class="journal-volume">8</span> <span class="journal-issue">2</span> <span class="page"> pp 215-223 </span> <span class="year">(2000)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0033770434" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0033770434"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="11061216" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11061216&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neuroscience (miscellaneous)   SJR indikátor: Q4</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 2 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt: 6 | WoS/Scopus jelölt: 6 | DOI jelölt: 4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1431249&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1431249</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> <span class="oldId">Régi azonosító: 1431249</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="special-affiliations"> Speciális affiliáció: Akadémikus bibliográfia </div> <div class="lastModified">Utolsó módosítás: 2025.07.02. 01:11 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :6 Export Date: 7 September 2020 CODEN: NROBE Correspondence Address: Meszaros, Zs.; Department of Pharmacodynamics, Semmelweis University of Medicine, Nagyvarad ter 4, H-1089 Budapest, Hungary Cited By :6 Export Date: 26 July 2021 CODEN: NROBE ...</pre> </div></div>