https://m2.mtmt.hu/ eng 2026-10-22 22:02 JournalArticle 1424451 APPROVED true Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083, Budapest, Hungary Research Group for Cortical Microcircuits of the Hungarian, Academy of Sciences, University of Szeged, H-6726, Szeged, Hungary Pázmány Péter Catholic University, H-1083, Budapest, Hungary Cited By :64 Export Date: 30 January 2024 CODEN: PNASA Correspondence Address: Rózsa, B.; Institute of Experimental Medicine, , H-1083, Budapest, Hungary; email: rozsabal@koki.hu Chemicals/CAS: n methyl dextro aspartic acid, 6384-92-5 0 2016-08-26T07:46:26.000+0000 false 1424451 2026-10-16T10:14:48.212+0000 2025-03-26T18:29:21.302+0000 2011-01-26T08:15:56.000+0000 true 10003154 Wolf György /api/admin/10003154 Admin true 10003154 2026-01-12T09:28:11.902+0000 2026-01-12T09:28:11.902+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Katona, G Roller Coaster Scanning reveals spontaneous triggering of dendritic spikes in CA1 interneurons true true /api/journal/3547 REVIEWED true false 3547 false 3547 true 0027-8424 1091-6490 Journal FOREIGN 108 5 2148 2153 2148 6 2011 Inhibitory interneurons are considered to be the controlling units of neural networks, despite their sparse number and unique morphological characteristics compared with excitatory pyramidal cells. Although pyramidal cell dendrites have been shown to display local regenerative events-dendritic spikes (dSpikes)-evoked by artificially patterned stimulation of synaptic inputs, no such studies exist for interneurons or for spontaneous events. In addition, imaging techniques have yet to attain the required spatial and temporal resolution for the detection of spontaneously occurring events that trigger dSpikes. Here we describe a high-resolution 3D two-photon laser scanning method (Roller Coaster Scanning) capable of imaging long dendritic segments resolving individual spines and inputs with a temporal resolution of a few milliseconds. By using this technique, we found that local, NMDA receptor-dependent dSpikes can be observed in hippocampal CA1 stratum radiatum interneurons during spontaneous network activities in vitro. These NMDA spikes appear when approximately 10 spatially clustered inputs arrive synchronously and trigger supralinear integration in dynamic interaction zones. In contrast to the one-to-one relationship between computational subunits and dendritic branches described in pyramidal cells, here we show that interneurons have relatively small ( approximately 14 mum) sliding interaction zones. Our data suggest a unique principle as to how interneurons integrate synaptic information by local dSpikes. 2011 true true true false true false NONE 2026-10-16 false true 10019198 Tóth Éva /api/admin/10019198 Admin true 10019198 85 0 70 58 18 69 69 66 69 69 69 57 57 72 13 0 85 72 70 58 0 14 14 Folyóiratcikk Journal Article 24 63 Könyvrészlet Chapter in Book 25 7 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 11 Egyéb Miscellaneous 29 4 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2011 0 1 1 1 1 2012 0 12 10 12 10 2013 0 5 5 5 5 2014 0 12 9 12 9 2015 0 9 7 9 7 2016 0 8 6 8 6 2017 0 0 0 0 0 2018 0 4 3 4 3 2019 0 8 7 8 7 2020 0 6 6 6 6 2021 0 5 4 5 4 2022 0 4 3 4 3 2023 0 3 3 3 3 2024 0 2 2 2 2 2025 0 5 5 5 5 2026 0 1 1 1 1 D1 A false false false false 2011-02-16T09:50:47.000+0000 2012-11-15T08:42:31.000+0000 Farmakológiai Kutatócsoport (KOKI / GYO); Hálózat-Idegélettani Kutatócsoport (KOKI / CHO); Információs Technológiai Kar (PPKE); Két-foton Képalkotó Központ (KOKI / GYO); MTA Kísérleti Orvostudományi Kutatóintézet; MTA-SZTE Agykérgi Neuronhálózatok Kutatócsoport (SZTE / TTIK / BI / ÉSZIT) 7 45 6 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 1286334 /api/authorship/1286334 1 0.143 true false Author 191 /api/author/191 Katona Gergely true 191 true Katona G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11643000 true PersonAuthorship 1286335 /api/authorship/1286335 2 0.143 false false Author 227 /api/author/227 Kaszás Attila true 227 true Kaszas A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11642999 true PersonAuthorship 1286336 /api/authorship/1286336 3 0.14285715 false false Author 145 /api/author/145 Turi Gergely true 145 true Turi GF true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11642998 true PersonAuthorship 1286337 /api/authorship/1286337 4 0.143 false false Author 10010484 /api/author/10010484 Hájos Norbert true 10010484 true Hajos N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11642997 true PersonAuthorship 1286338 /api/authorship/1286338 5 0.14285715 false false Author 10000392 /api/author/10000392 Tamás Gábor true 10000392 true Tamas G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11642996 true PersonAuthorship 1286339 /api/authorship/1286339 6 0.143 false false Author 10000023 /api/author/10000023 Vizi E. 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Földtudományok Osztálya HAS Section of Earth Sciences (X.) true 70 true true true A true true MtaRating 11551102 /api/mtarating/11551102 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true A nemzetközi false true MtaRating 519088 /api/mtarating/519088 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19088 true SjrRating 5720880 /api/sjrrating/5720880 3 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true 5720880 true /api/publication/1424451 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="191"><a href="/gui2/?type=authors&mode=browse&sel=191" target="_blank">Katona G (<span class="authorship-author-name">Katona Gergely</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="227"><a href="/gui2/?type=authors&mode=browse&sel=227" target="_blank">Kaszas A (<span class="authorship-author-name">Kaszás Attila</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Drug Research; <span title="Pázmány Péter Catholic University">PPCU</span>/Faculty of Information Technology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="145"><a href="/gui2/?type=authors&mode=browse&sel=145" target="_blank">Turi GF (<span class="authorship-author-name">Turi Gergely</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Two-photon Imaging Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010484"><a href="/gui2/?type=authors&mode=browse&sel=10010484" target="_blank">Hajos N (<span class="authorship-author-name">Hájos Norbert</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Network Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000392"><a href="/gui2/?type=authors&mode=browse&sel=10000392" target="_blank">Tamas G (<span class="authorship-author-name">Tamás Gábor</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/<span title="Department of Physiology, Anatomy and Neuroscience">ÉSZIT</span>/MTA-SZTE Research Group for Cortical Microcircuits</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000023"><a href="/gui2/?type=authors&mode=browse&sel=10000023" target="_blank">Vizi ES (<span class="authorship-author-name">Vizi E. Szilveszter</span> <span class="authorAux-mtmt"> Neurofarmakológia, neurokémia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Drug Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012926"><a href="/gui2/?type=authors&mode=browse&sel=10012926" target="_blank">Rozsa B ✉ (<span class="authorship-author-name">Rózsa J. Balázs</span> <span class="authorAux-mtmt"> Idegtudomány, fizika</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet; <span title="Pázmány Péter Catholic University">PPCU</span>/Faculty of Information Technology; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Two-photon Imaging Center</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1424451" target="_blank">Roller Coaster Scanning reveals spontaneous triggering of dendritic spikes in CA1 interneurons</a></div> <div> <span class="journal-title">PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0027-8424">0027-8424</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1091-6490">1091-6490</a>)</span>: <span class="journal-volume">108</span> <span class="journal-issue">5</span> <span class="page"> pp 2148-2153 </span> <span class="year">(2011)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1073/pnas.1009270108" target="_blank" href="https://doi.org/10.1073/pnas.1009270108"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000286804700074" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000286804700074"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="79952123591" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-79952123591"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="21224413" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21224413&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">HAS Section of Earth Sciences (X.) HASSESX&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 85</span> | Independent citation: 72 | Self citation: 13 | Unknown citation: 0 | Number of citations in WoS: 66 | Number of citations in Scopus:&nbsp;69 | WoS/Scopus assigned:&nbsp;69 | Number of citations with DOI:&nbsp;69 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1424451&sort=publishedYear,desc&sort=title"> Number of cited publications: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 1424451</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 1424451</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.03.26. 19:29 Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083, Budapest, Hungary Research Group for Cortical Microcircuits of the Hungarian, Academy of Sciences, University of Szeged, H-6726, Szeged, Hungary Pázmány Péter Catholic University, H-1083, Budapest, Hungary Cited By :64 Export ...</pre> </div></div>