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Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice
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Csiszar A, Labinskyy N, Perez V, Recchia FA, Podlutsky A, Mukhopadhyay P, Losonczy G, Pacher P, Austad SN, Bartke A, Ungvari Z. Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice. Am J Physiol Heart Circ Physiol 295: H1882-H1894, 2008. First published August 29, 2008; doi:10.1152/ajpheart.412.2008. - Hypopituitary Ames dwarf mice have low circulating growth hormone (GH)/IGF-I levels, and they have extended longevity and exhibit many symptoms of delayed aging. To elucidate the vascular consequences of Ames dwarfism we compared endothelial O-2(center dot-) and H2O2 production, mitochondrial reactive oxygen species (ROS) generation, expression of antioxidant enzymes, and nitric oxide (NO) production in aortas of Ames dwarf and wild-type control mice. In Ames dwarf aortas endothelial O-2(center dot-) and H2O2 production and ROS generation by mitochondria were enhanced compared with those in vessels of wild-type mice. In Ames dwarf aortas there was a less abundant expression of Mn-SOD, Cu, Zn-SOD, glutathione peroxidase (GPx)-1, and endothelial nitric oxide synthase (eNOS). NO production and acetylcholine-induced relaxation were also decreased in aortas of Ames dwarf mice. In cultured wild-type mouse aortas and in human coronary arterial endothelial cells treatment with GH and IGF significantly reduced cellular O-2(center dot-) and H2O2 production and ROS generation by mitochondria and upregulated expression of Mn-SOD, Cu, Zn-SOD, GPx-1, and eNOS. Thus GH and IGF-I promote antioxidant phenotypic changes in the endothelial cells, whereas Ames dwarfism leads to vascular oxidative stress.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10071157"> <a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Labinskyy, N </span> <span class="author-type"> </span> ; <span class="author-name" > Perez, V </span> <span class="author-type"> </span> ; <span class="author-name" > Recchia, FA </span> <span class="author-type"> </span> ; <span class="author-name" > Podlutsky, A </span> <span class="author-type"> </span> ; <span class="author-name" > Mukhopadhyay, P </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10004124"> <a href="/gui2/?type=authors&mode=browse&sel=10004124" target="_blank">Losonczy, G</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10035169"> <a href="/gui2/?type=authors&mode=browse&sel=10035169" target="_blank">Pacher, P</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Austad, SN </span> <span class="author-type"> </span> ; <span class="author-name" > Bartke, A </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1416573" mtid="1416573" target="_blank">Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice</a></div> <div class="pub-info"> <span class="journal-title">AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY</span> <span class="journal-volume">295</span> : <span class="journal-issue">5</span> <span class="page"> pp. H1882-H1894. </span> <span class="year">(2008)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1152/ajpheart.412.2008" target="_blank" href="https://doi.org/10.1152/ajpheart.412.2008"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000260722600007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000260722600007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="57049132064" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-57049132064"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="18757483" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18757483&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1416573 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 128</span> | Független: 77 | Függő: 51 | Nem jelölt: 0 | WoS jelölt: 123 | Scopus jelölt: 126 | WoS/Scopus jelölt: 128 | DOI jelölt: 126 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar A (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> ; <span class="author-name" >Labinskyy N </span> ; <span class="author-name" >Perez V </span> ; <span class="author-name" >Recchia FA </span> ; <span class="author-name" >Podlutsky A </span> ; <span class="author-name" >Mukhopadhyay P </span> ; <span class="author-name" mtid="10004124"><a href="/gui2/?type=authors&mode=browse&sel=10004124" target="_blank">Losonczy G (<span class="authorship-author-name">Losonczy György</span> <span class="authorAux-mtmt"> Pulmonológia, klinikai onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> ; <span class="author-name" mtid="10035169"><a href="/gui2/?type=authors&mode=browse&sel=10035169" target="_blank">Pacher P (<span class="authorship-author-name">Pacher Pál</span> <span class="authorAux-mtmt"> Kardiovaszkuláris Farmakológia</span>) </a> </span> ; <span class="author-name" >Austad SN </span> ; <span class="author-name" >Bartke A </span> ; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Z ✉ (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, élettan, kórélettan, gerontológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;1416573" target="_blank">Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice</a></div> <div> <span class="journal-title">AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0363-6135">0363-6135</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1522-1539">1522-1539</a>)</span>: <span class="journal-volume">295</span> <span class="journal-issue">5</span> <span class="page"> pp H1882-H1894 </span> <span class="year">(2008)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1152/ajpheart.412.2008" target="_blank" href="https://doi.org/10.1152/ajpheart.412.2008"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000260722600007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000260722600007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="57049132064" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-57049132064"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="18757483" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18757483&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 128</span> | Független: 77 | Függő: 51 | Nem jelölt: 0 | WoS jelölt: 123 | Scopus jelölt: 126 | WoS/Scopus jelölt: 128 | DOI jelölt: 126 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1416573&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1416573</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 1416573</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2023.09.02. 16:02 Milánkovics Róbert (PTE ÁOK admin 4) </div> </div></div>