https://m2.mtmt.hu/ hun 2026-05-30 12:54 JournalArticle 1405827 VALIDATED true Megjegyzés-21114607 Chemicals/CAS: alpha tubulin, 78769-62-7; nicotinamide phosphoribosyltransferase, 9030-27-7; protein, 67254-75-5 Megjegyzés-21116230 Chemicals/CAS: alpha tubulin, 78769-62-7; nicotinamide phosphoribosyltransferase, 9030-27-7; protein, 67254-75-5 Megjegyzés-21116358 Chemicals/CAS: alpha tubulin, 78769-62-7; nicotinamide phosphoribosyltransferase, 9030-27-7; protein, 67254-75-5 0 2014-10-16T16:18:28.000+0000 false 1405827 2026-05-27T07:39:57.615+0000 2025-05-09T11:53:13.132+0000 2010-12-07T08:11:16.000+0000 true 10003262 Radák Zsolt /api/author/10003262 Author Radák Zsolt (Sporttudomány) true 10003262 2025-08-25T08:19:53.095+0000 2025-08-25T08:19:53.095+0000 2025-05-09T11:53:13.378+0000 true 10067876 Ladányi Gusztáv /api/admin/10067876 Admin Ladányi Gusztáv (MTMT API user, admin) true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv (MTMT API user, admin) Ladányi Gusztáv true true 2025-05-09T11:53:12.149+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Marton, O true true /api/journal/27308 REVIEWED BIOGERONTOLOGY 1389-5729 1573-6768 true false 27308 false 27308 true 1389-5729 1573-6768 Journal FOREIGN 11 6 679 686 679 8 2010 Aging is associated with a gradual decline in cognitive and motor functions, the result of complex biochemical processes including pre- and posttranslational modifications of proteins. Sirtuins are NAD⁺ dependent protein deacetylases. These enzymes modulate the aging process by lysine deacetylation, which alters the activity and stability of proteins. Exercise can increase mean life-span and improve quality of life. Data from our laboratories revealed that 4 weeks of treadmill running improves performance in the Morris Maze test for young (4 months, old) but not old (30 months, old) male rats, and the exercise could not prevent the age-associated loss in muscle strength assessed by a gripping test. The positive correlation between protein acetylation and the gripping test suggests that the age-dependent decrease in relative activity of SIRT1 in the cerebellum impairs motor function. Similarly to the acetylation level of total proteins, the acetylation of α′-tubulin is also increased with aging, while the effect of exercise training was not found to be significant. Moreover, the protein content of nicotinamide phosphoribosyltransferase, one of the key enzymes of NAD biosynthesis, decreased in the young exercise group. These data suggest that aging results in decreased specific activity of SIRT1 in cerebellum, which could lead to increased acetylation of protein residues, including α′-tubulin, that interfere with motor function. © 2010 Springer Science+Business Media B.V. 2010 true true true false true false NONE 2026-05-27 false 71 0 64 53 12 63 61 53 57 59 59 48 48 58 13 0 71 58 64 53 0 6 6 Folyóiratcikk Journal Article 24 58 Könyvrészlet Chapter in Book 25 6 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 6 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2010 0 2 1 2 1 2011 0 6 4 6 4 2012 0 5 5 5 5 2013 0 9 6 9 6 2014 0 6 4 6 4 2015 0 7 6 7 6 2016 0 6 6 6 6 2017 0 2 2 2 2 2018 0 3 2 3 2 2019 0 0 0 0 0 2020 0 7 5 7 5 2021 0 4 4 4 4 2022 0 4 4 4 4 2023 0 4 4 4 4 2024 0 4 4 4 4 2025 0 2 1 2 1 D1 false false false false 2013-10-17T10:28:38.000+0000 2013-02-23T19:18:00.000+0000 Sporttudományi Kutatóintézet (SE / TF) 5 51 1 8 0 true 10067876 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 1187012 /api/authorship/1187012 Marton, O [Marton, Orsolya (élettan), szerző] 1 0.125 true false Author 10027154 /api/author/10027154 Marton Orsolya (élettan) Marton Orsolya true 10027154 true Marton O true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11444656 true PersonAuthorship 1187013 /api/authorship/1187013 Koltai, E [Koltai, Erika (sporttudomány), szerző] Sporttudományi Kutatóintézet (SE / TF) 2 0.125 false false Author 10022305 /api/author/10022305 Koltai Erika (sporttudomány) Koltai Erika true 10022305 true Koltai E true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11444655 true PersonAuthorship 1187014 /api/authorship/1187014 Nyakas, C [Nyakas, Csaba (Molekuláris neuro...), szerző] Sporttudományi Kutatóintézet (SE / TF) 3 0.125 false false Author 10010173 /api/author/10010173 Nyakas Csaba (Molekuláris neurobiológia) Nyakas Csaba true 10010173 true Nyakas C true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11444654 true PersonAuthorship 1187015 /api/authorship/1187015 Bakonyi, T [Bakonyi, Tibor (Nevelés- és sport...), szerző] 4 0.125 false false Author 10011909 /api/author/10011909 Bakonyi Tibor (Nevelés- és sporttudomány) Bakonyi Tibor true 10011909 true Bakonyi T true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11444653 true PersonAuthorship 1187016 /api/authorship/1187016 Zenteno-Savin, T 5 0.125 false false Zenteno-Savin T true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11444652 true PersonAuthorship 1187017 /api/authorship/1187017 Kumagai, S 6 0.125 false false Kumagai S true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11444651 true PersonAuthorship 1187018 /api/authorship/1187018 Goto, S 7 0.125 false false Goto S true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11444650 true PersonAuthorship 1187019 /api/authorship/1187019 Radak, Z [Radák, Zsolt (Sporttudomány), szerző] Sporttudományi Kutatóintézet (SE / TF) 8 0.125 false true Author 10003262 /api/author/10003262 Radák Zsolt (Sporttudomány) Radák Zsolt true 10003262 true Radak Z true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 11444649 true PublicationIdentifier 312442 /api/publicationidentifier/312442 DOI: 10.1007/s10522-010-9279-2 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1007/s10522-010-9279-2 https://doi.org/10.1007/s10522-010-9279-2 false 171061 true PublicationIdentifier 312440 /api/publicationidentifier/312440 WoS: 000283917800003 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000283917800003 https://www.webofscience.com/wos/woscc/full-record/000283917800003 false 171062 true PublicationIdentifier 312441 /api/publicationidentifier/312441 Scopus: 78049268948 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 78049268948 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-78049268948 false 171063 true PublicationIdentifier 312443 /api/publicationidentifier/312443 PubMed: 20467811 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 20467811 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20467811&dopt=Abstract false 524259 true Classification 12125 /api/classification/12125 Általános orvostudomány true true Classification 10545 /api/classification/10545 Biológiai tudományok true true Classification 12347 /api/classification/12347 Egészségtudományok true true Classification 12215 /api/classification/12215 Klinikai orvostan true true Keyword 62 /api/keyword/62 Male true 62 true Keyword 473 /api/keyword/473 PROTEIN true 473 true Keyword 1699 /api/keyword/1699 ARTICLE true 1699 true Keyword 4156 /api/keyword/4156 Quality of Life true 4156 true Keyword 4600 /api/keyword/4600 priority journal true 4600 true Keyword 4608 /api/keyword/4608 controlled study true 4608 true Keyword 4862 /api/keyword/4862 NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE true 4862 true Keyword 5079 /api/keyword/5079 nonhuman true 5079 true Keyword 5087 /api/keyword/5087 animal experiment true 5087 true Keyword 5308 /api/keyword/5308 biosynthesis true 5308 true Keyword 6341 /api/keyword/6341 Aging true 6341 true Keyword 6421 /api/keyword/6421 CEREBELLUM true 6421 true Keyword 6666 /api/keyword/6666 enzyme activity true 6666 true Keyword 8096 /api/keyword/8096 Acetylation true 8096 true Keyword 8129 /api/keyword/8129 Protein Stability true 8129 true Keyword 11267 /api/keyword/11267 Exercise true 11267 true Keyword 13171 /api/keyword/13171 PROTEIN FUNCTION true 13171 true Keyword 14246 /api/keyword/14246 protein blood level true 14246 true Keyword 1006710 /api/keyword/1006710 lifespan true 1006710 true Keyword 1007925 /api/keyword/1007925 treadmill exercise true 1007925 true Keyword 1007926 /api/keyword/1007926 muscle strength true 1007926 true Keyword 1007927 /api/keyword/1007927 motor performance true 1007927 true Keyword 1007928 /api/keyword/1007928 deacetylation true 1007928 true Keyword 1007929 /api/keyword/1007929 sirtuin 1 true 1007929 true Keyword 1007930 /api/keyword/1007930 alpha tubulin true 1007930 true Keyword 1007931 /api/keyword/1007931 SIRT1 true 1007931 true Keyword 1007932 /api/keyword/1007932 Acetylation/deacetylation true 1007932 true Keyword 1554523 /api/keyword/1554523 rat true true SjrRating 5769511 /api/sjrrating/5769511 sjr:D1 (2010) Scopus - Gerontology BIOGERONTOLOGY 1389-5729 1573-6768 4 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2909 /api/classificationexternal/2909 Scopus - Gerontology true 2909 true D1 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Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats. (2010) BIOGERONTOLOGY 1389-5729 1573-6768 11 6 679-686<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10027154"><a href="/gui2/?type=authors&mode=browse&sel=10027154" target="_blank">Marton O (<span class="authorship-author-name">Marton Orsolya</span> <span class="authorAux-mtmt"> élettan</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022305"><a href="/gui2/?type=authors&mode=browse&sel=10022305" target="_blank">Koltai E (<span class="authorship-author-name">Koltai Erika</span> <span class="authorAux-mtmt"> sporttudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Testnevelési és Sporttudományi Kar">TF</span>/Sporttudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010173"><a href="/gui2/?type=authors&mode=browse&sel=10010173" target="_blank">Nyakas C (<span class="authorship-author-name">Nyakas Csaba</span> <span class="authorAux-mtmt"> Molekuláris neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Testnevelési és Sporttudományi Kar">TF</span>/Sporttudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011909"><a href="/gui2/?type=authors&mode=browse&sel=10011909" target="_blank">Bakonyi T (<span class="authorship-author-name">Bakonyi Tibor</span> <span class="authorAux-mtmt"> Nevelés- és sporttudomány</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zenteno-Savin T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kumagai S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Goto S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003262"><a href="/gui2/?type=authors&mode=browse&sel=10003262" target="_blank">Radak Z (<span class="authorship-author-name">Radák Zsolt</span> <span class="authorAux-mtmt"> Sporttudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Testnevelési és Sporttudományi Kar">TF</span>/Sporttudományi Kutatóintézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1405827" target="_blank">Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats</a></div> <div> <span class="journal-title">BIOGERONTOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1389-5729">1389-5729</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1573-6768">1573-6768</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">6</span> <span class="page"> pp 679-686 </span> <span class="year">(2010)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s10522-010-9279-2" target="_blank" href="https://doi.org/10.1007/s10522-010-9279-2"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000283917800003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000283917800003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="78049268948" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-78049268948"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="20467811" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20467811&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 71</span> | Független: 58 | Függő: 13 | Nem jelölt: 0 | WoS jelölt: 53 | Scopus jelölt:&nbsp;57 | WoS/Scopus jelölt:&nbsp;59 | DOI jelölt:&nbsp;61 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1405827&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1405827</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 1405827</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2025.05.09. 13:53 Ladányi Gusztáv (MTMT API user, admin) </div> <div class="lockedBy">Központi kezelésű 2025.05.09. 13:53 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megjegyzés-21114607 Chemicals/CAS: alpha tubulin, 78769-62-7; nicotinamide phosphoribosyltransferase, 9030-27-7; protein, 67254-75-5 Megjegyzés-21116230 Chemicals/CAS: alpha tubulin, 78769-62-7; nicotinamide phosphoribosyltransferase, 9030-27-7; protein, 67254-75-5 Megjegyzés-21116358 Chemicals/CAS: alpha tubulin, 78769-62-7; nicotinamide phosphoribosyltransferase, 9030-27-7; protein, 67254-75-5</pre> </div></div>