https://m2.mtmt.hu/ hun 2026-08-26 05:33 JournalArticle 1378688 ADMIN_APPROVED true 0 2015-03-31T14:40:33.000+0000 false 1378688 2026-07-08T06:02:05.156+0000 2015-03-31T14:40:33.000+0000 2010-09-27T20:29:47.000+0000 true 10008291 Brücher Ernő /api/author/10008291 Author true 10008291 2018-10-20T15:21:47.114+0000 2018-10-20T15:21:47.114+0000 2015-03-31T14:40:33.000+0000 true 10014931 Farkas Andrea /api/admin/10014931 Admin true 10014931 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 MICSKEI, K O-17 NMR-STUDY OF WATER EXCHANGE ON [GD(DTPA)(H2O)]2- AND [GD(DOTA)(H2O)]- RELATED TO NMR IMAGING true true /api/journal/1973 REVIEWED true false 1973 false 1973 true 0020-1669 1520-510X Journal FOREIGN 32 18 3844 3850 3844 7 1993 The water-exchange rate constants for the [Gd(DTPA)(H2O)]2- and [Gd(DOTA)(H2O)]-complexes as determined by variable-temperature O-17 NMR are respectively k(ex)298 = (4.1 +/- 0.3) X 10(6) and (4.8 +/- 0.4) X 10(6) s-1. The activation volumes (DELTAV(double dagger)), measured up to 200 MPa, are 12.5 +/- 0.2 and 10.5 +/- 0.2 cm3 mol-1, indicating an extreme dissociative activation mode for the water-exchange mechanism. The mechanism (D) is further supported by the large activation enthalpies (DELTAH(double dagger) = +52.0 +/- 1.4 and +48.8 +/- 1.6 kJ mol-1) and positive entropies (DELTAS(double dagger) = +56.2 +/- 5 and +46.6 +/- 6 kJ mol-1 K-1) obtained for the [Gd(DTPA)(H2O)]2- and [Gd(DOTA)(H2O)]- complexes, respectively. In the first coordination sphere of these two monoaqua complexes there is only space for one water molecule, and thus the bond breaking of the coordinated water should be the rate-determining step. The O-17 relaxation contribution of the second coordination sphere was estimated by investigating [Gd(TETA)]-, which has no water in the first coordination sphere. All these considerations lead to the conclusion that the effectiveness of [Gd(DTPA)(H2O)]2- and [Gd(DOTA)(H2O)]- as contrast agents in MRI is not limited by the relatively low water-exchange rates but by T1m, the longitudinal relaxation time of water protons in the first coordination sphere. 2010 true true true false true false NONE 2026-07-08 false 246 0 246 186 20 241 235 238 205 246 246 186 186 186 60 0 246 186 246 186 0 0 0 Folyóiratcikk Journal Article 24 238 Könyvrészlet Chapter in Book 25 8 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 1993 0 1 0 1 0 1994 0 8 5 8 5 1995 0 12 9 12 9 1996 0 11 8 11 8 1997 0 10 5 10 5 1998 0 15 9 15 9 1999 0 17 11 17 11 2000 0 9 7 9 7 2001 0 11 9 11 9 2002 0 8 3 8 3 2003 0 8 6 8 6 2004 0 14 11 14 11 2005 0 17 9 17 9 2006 0 5 5 5 5 2007 0 7 7 7 7 2008 0 6 6 6 6 2009 0 4 4 4 4 2010 0 7 7 7 7 2011 0 6 6 6 6 2012 0 9 4 9 4 2013 0 9 8 9 8 2014 0 5 5 5 5 2015 0 5 3 5 3 2016 0 7 6 7 6 2017 0 4 4 4 4 2018 0 3 2 3 2 2019 0 7 7 7 7 2020 0 5 4 5 4 2021 0 3 3 3 3 2022 0 5 5 5 5 2023 0 0 0 0 0 2024 0 3 3 3 3 2025 0 2 2 2 2 2026 0 3 3 3 3 false false false false 2015-03-31T14:40:33.000+0000 2013-01-21T19:38:28.000+0000 Szervetlen és Analitikai Kémiai Tanszék (DE / TTK / KemI) 2 8 1 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 1076396 /api/authorship/1076396 1 0.25 true false Author 10005689 /api/author/10005689 Micskei Károly Endre true 10005689 true MICSKEI K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11220873 true PersonAuthorship 1076397 /api/authorship/1076397 2 0.25 false false HELM L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11220872 true PersonAuthorship 1076398 /api/authorship/1076398 3 0.25 false false Author 10008291 /api/author/10008291 Brücher Ernő true 10008291 true BRUCHER E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11220871 true PersonAuthorship 1076399 /api/authorship/1076399 4 0.25 false true MERBACH AE true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 11220870 true PublicationIdentifier 296625 /api/publicationidentifier/296625 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false NO 10.1021/ic00070a013 https://doi.org/10.1021/ic00070a013 false 158825 true PublicationIdentifier 296623 /api/publicationidentifier/296623 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL A1993LV76600013 https://www.webofscience.com/wos/woscc/full-record/A1993LV76600013 false 158826 true PublicationIdentifier 296624 /api/publicationidentifier/296624 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false NO 1542307980 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-1542307980 false 158827 true Classification 10293 /api/classification/10293 true true Keyword 453 /api/keyword/453 true 453 true Keyword 2093 /api/keyword/2093 true 2093 true Keyword 2321 /api/keyword/2321 true 2321 true Keyword 2610 /api/keyword/2610 true 2610 true Keyword 3195 /api/keyword/3195 true 3195 true Keyword 1000099 /api/keyword/1000099 true 1000099 true Keyword 1001952 /api/keyword/1001952 true 1001952 true Keyword 1002102 /api/keyword/1002102 true 1002102 true /api/publication/1378688 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10005689"><a href="/gui2/?type=authors&mode=browse&sel=10005689" target="_blank">MICSKEI K (<span class="authorship-author-name">Micskei Károly Endre</span> <span class="authorAux-mtmt"> Szervetlen kémia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/<span title="Kémiai Intézet">KemI</span>/Szervetlen és Analitikai Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >HELM L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008291"><a href="/gui2/?type=authors&mode=browse&sel=10008291" target="_blank">BRUCHER E (<span class="authorship-author-name">Brücher Ernő</span> <span class="authorAux-mtmt"> Szervetlen kémia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/<span title="Kémiai Intézet">KemI</span>/Szervetlen és Analitikai Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >MERBACH AE </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1378688" target="_blank">O-17 NMR-STUDY OF WATER EXCHANGE ON [GD(DTPA)(H2O)]2- AND [GD(DOTA)(H2O)]- RELATED TO NMR IMAGING</a></div> <div> <span class="journal-title">INORGANIC CHEMISTRY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0020-1669">0020-1669</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1520-510X">1520-510X</a>)</span>: <span class="journal-volume">32</span> <span class="journal-issue">18</span> <span class="page"> pp 3844-3850 </span> <span class="year">(1993)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1021/ic00070a013" target="_blank" href="https://doi.org/10.1021/ic00070a013"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="A1993LV76600013" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/A1993LV76600013"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="1542307980" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-1542307980"> Scopus </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 246</span> | Független: 186 | Függő: 60 | Nem jelölt: 0 | WoS jelölt: 238 | Scopus jelölt:&nbsp;205 | WoS/Scopus jelölt:&nbsp;246 | DOI jelölt:&nbsp;235 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1378688</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> <span class="oldId">Régi azonosító: 1378688</span> | Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2015.03.31. 16:40 Farkas Andrea (MTMT Központ, admin) </div> </div></div>