Calcium-sensing receptor (CaSR) is an attractive candidate gene for osteoporosis susceptibility.
The CaSR "A986S" genotype has been shown to have an effect on serum calcium. Recently,
an association has been reported between the CaSR gene A986S polymorphism and bone
mineral density in healthy white girls. In this study, we examined whether CaSR gene
A986S polymorphism is associated with decreased bone mass in 230 Hungarian postmenopausal
women. From this cohort, 108 osteoporotic patients were compared with 122 healthy
control women. Bone mineral density (BMD) was measured at the lumbar spine (L2-4)
and femoral neck using dual-energy X-ray absorptiometry. Allele-specific polymerase
chain reaction was used to amplify A986S polymorphisms of the CaSR gene. We found
no difference in the distribution of different alleles or genotypes between groups
(p = 0.762). No significant effect of CaSR genotype on BMD was observed either in
the whole population or in the subgroups. Our data do not support the idea that CaSR
gene A986S polymorphism has an impact on bone mass.
