Introduction: In situ biomechanical properties of peripheral large veins were compared
between asymptomatic young patients who had previously unilateral femoro-popliteal
deep venous thrombosis (DVT) and age-matched, healthy controls; the aim of this study
was to assess local or generalized alterations of venous watt biomechanics in postthrombotic
patients. Patients and methods: Inner diameters of both common femoral veins, right
axillary vein, and right internal jugular veins were measured in two directions by
uttrasonography. Venous pressure was altered by posture changes (standing and tying)
and by application of graded and controlled Valsava. Ten postthrombotic young patients
without any symptoms and 11 age-matched control subjects were included. Results: In
postthrombotic patients, both the affected and unaffected common femoral vein diameters
and capacities were larger at tow transmural pressures than those for the control
group, but they demonstrated significantly less distensibitity when higher pressures
were applied. Similarly, in the internal jugular vein, capacity without Vatsalva was
significantly higher in postthrombotic patients and distensibility was reduced (statistically
significant in the erect position). Pressure-induced changes in axillary vein diameter
were negligible. Conclusions: In situ diameter and capacity changes, and in situ distensibility
of the femoral veins on both sides (i.e., the side of previous thrombosis as well
as the disease free side) and of the jugular veins are reduced in the young DVT patients
compared to veins of the age-matched, healthy controls. The pathophysiotogicat mechanism
of generalized venous watt changes in these young DVT patients remains unknown. (c)
2005 Elsevier Ltd. All rights reserved.
