https://m2.mtmt.hu/ eng 2026-05-02 14:38 JournalArticle 1290342 VALIDATED true Department of Biophysics, KFKI Research Institute for Particle and Nuclear Physics, Hungarian Academy of Sciences, Budapest, Hungary Center for Complex Systems Studies, Kalamazoo College, Kalamazoo, MI, United States Cited By :19 Export Date: 12 June 2024 Correspondence Address: Ujfalussy, B.; Department of Biophysics, , Budapest, Hungary; email: ubi@rmki.kfki.hu 0 2018-09-13T03:06:16.000+0000 false 1290342 2026-03-24T10:22:07.530+0000 2024-04-09T08:29:17.473+0000 2009-12-27T23:00:00.000+0000 true 10002468 Érdi Péter /api/author/10002468 Author true 10002468 2025-03-24T11:31:00.764+0000 2025-03-24T11:31:00.764+0000 2024-04-09T08:29:17.812+0000 true 10079265 Tomcsik Adrienn /api/admin/10079265 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ujfalussy, B Parallel Computational Subunits in Dentate Granule Cells Generate Multiple Place Fields true true /api/journal/10003477 REVIEWED true false 10003477 false 10003477 true 1553-734X 1553-7358 Journal FOREIGN 5 9 e1000500 e1000500 16 2009 A fundamental question in understanding neuronal computations is how dendritic events influence the output of the neuron. Different forms of integration of neighbouring and distributed synaptic inputs, isolated dendritic spikes and local regulation of synaptic efficacy suggest that individual dendritic branches may function as independent computational subunits. In the present paper, we study how these local computations influence the output of the neuron. Using a simple cascade model, we demonstrate that triggering somatic firing by a relatively small dendritic branch requires the amplification of local events by dendritic spiking and synaptic plasticity. The moderately branching dendritic tree of granule cells seems optimal for this computation since larger dendritic trees favor local plasticity by isolating dendritic compartments, while reliable detection of individual dendritic spikes in the soma requires a low branch number. Finally, we demonstrate that these parallel dendritic computations could contribute to the generation of multiple independent place fields of hippocampal granule cells. 2009 true true true false false GOLD 2026-03-24 true https://doi.org/10.1371/journal.pcbi.1000500 true 10039656 Kmety Andrea /api/admin/10039656 Admin true 10039656 21 0 20 18 4 20 20 20 19 20 20 18 18 19 2 0 21 19 20 18 0 9 9 Folyóiratcikk Journal Article 24 20 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 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true PersonAuthorship 892376 /api/authorship/892376 3 0.33333334 false true Author 10002468 /api/author/10002468 Érdi Péter true 10002468 true Erdi P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10931917 true PublicationIdentifier 250794 /api/publicationidentifier/250794 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1371/journal.pcbi.1000500 https://doi.org/10.1371/journal.pcbi.1000500 false 125608 true PublicationIdentifier 250792 /api/publicationidentifier/250792 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000270800100018 https://www.webofscience.com/wos/woscc/full-record/000270800100018 false 125609 true PublicationIdentifier 250793 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true true Google scholar http://scholar.Google.com/scholar?hl=en&lr=&cluster=@@@ true true 12 true false NO 1419416033797086654 http://scholar.Google.com/scholar?hl=en&lr=&cluster=1419416033797086654 false 656948 true Classification 10003 /api/classification/10003 true true Classification 10034 /api/classification/10034 true true SjrRating 5814296 /api/sjrrating/5814296 4 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2804 /api/classificationexternal/2804 true 2804 true D1 DIRECT true 5814296 true /api/publication/1290342 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10017153"><a href="/gui2/?type=authors&mode=browse&sel=10017153" target="_blank">Ujfalussy B (<span class="authorship-author-name">Ujfalussy Balázs Benedek</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="MTA KFKI Institute for Particle and Nuclear Physics">KFKI RMKI</span>/Biophysics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012667"><a href="/gui2/?type=authors&mode=browse&sel=10012667" target="_blank">Kiss T (<span class="authorship-author-name">Kiss Tamás</span> <span class="authorAux-mtmt"> Elméleti idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA KFKI Institute for Particle and Nuclear Physics">KFKI RMKI</span>/Biophysics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002468"><a href="/gui2/?type=authors&mode=browse&sel=10002468" target="_blank">Erdi P (<span class="authorship-author-name">Érdi Péter</span> <span class="authorAux-mtmt"> Fizikai kémia, matematikai modellek, elméleti n...</span>) </a> </span> <span class="author-affil"><span title="MTA KFKI Institute for Particle and Nuclear Physics">KFKI RMKI</span>/Biophysics</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1290342" target="_blank">Parallel Computational Subunits in Dentate Granule Cells Generate Multiple Place Fields</a></div> <div> <span class="journal-title">PLOS COMPUTATIONAL BIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1553-734X">1553-734X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1553-7358">1553-7358</a>)</span>: <span class="journal-volume">5</span> <span class="journal-issue">9</span> <span class="page"> Paper e1000500. 16 p. </span> <span class="year">(2009)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" 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</span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Computational Theory and Mathematics&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Ecology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Ecology, Evolution, Behavior and Systematics&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Modeling and Simulation&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Genetics&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 21</span> | Independent citation: 19 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 20 | Number of citations in Scopus:&nbsp;19 | WoS/Scopus assigned:&nbsp;20 | Number of citations with DOI:&nbsp;20 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1290342&sort=publishedYear,desc&sort=title"> Number of cited publications: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 1290342</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 1290342</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="notDuplums"><a target="_blank" href="/api/publication/1290342/notduplums">2 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2024.04.09. 10:29 Adrienn Tomcsik (Wigner admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Biophysics, KFKI Research Institute for Particle and Nuclear Physics, Hungarian Academy of Sciences, Budapest, Hungary Center for Complex Systems Studies, Kalamazoo College, Kalamazoo, MI, United States Cited By :19 Export Date: 12 June 2024 Correspondence Address: Ujfalussy, B.; Depart...</pre> </div></div>