{ "labelLang" : "hun", "responseDate" : "2024-03-29 12:07", "content" : { "otype" : "JournalArticle", "mtid" : 1256956, "status" : "ADMIN_APPROVED", "published" : true, "comment" : "Megjegyzés-21981593\nChemicals/CAS: 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate, 87134-87-0; apomorphine, 314-19-2, 58-00-4; dopamine, 51-61-6, 62-31-7; raclopride, 84225-95-6; Apomorphine, 58-00-4; Receptors, Dopamine D1; Receptors, Dopamine D2\nTradenames: sch 23390", "unhandledTickets" : 0, "oldTimestamp" : "2017-06-08T10:49:07.000+0000", "deleted" : false, "oldId" : 1256956, "lastRefresh" : "2024-02-15T04:34:32.908+0000", "lastModified" : "2020-01-24T10:19:04.871+0000", "created" : "2009-09-14T22:00:00.000+0000", "creator" : { "otype" : "Author", "mtid" : 10001677, "link" : "/api/author/10001677", "label" : "Berényi Sándor Zsolt (Szerves kémia)", "familyName" : "Berényi", "givenName" : "Sándor Zsolt", "published" : true, "oldId" : 10001677, "snippet" : true }, "lastDuplumOK" : "2020-01-28T07:05:58.301+0000", "lastDuplumSearch" : "2020-01-28T07:05:58.301+0000", "adminApproved" : "2009-12-16T15:12:51.000+0000", "adminApprover" : { "otype" : "Admin", "mtid" : 10003134, "link" : "/api/admin/10003134", "label" : "Wolf György (MTMT Központi admin)", "familyName" : "Wolf", "givenName" : "György", "published" : true, "oldId" : 10003134, "snippet" : true }, "core" : true, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Herm, L", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 825332, "link" : "/api/authorship/825332", "label" : "Herm, L", "listPosition" : 1, "share" : 0.2, "first" : true, "last" : false, "familyName" : "Herm", "givenName" : "L", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 10829158, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 825333, "link" : "/api/authorship/825333", "label" : "Berenyi, S [Berényi, Sándor Zsolt (Szerves kémia), szerző] Szerves Kémiai Tanszék (DE / TTK / KemI)", "listPosition" : 2, "share" : 0.2, "first" : false, "last" : false, "author" : { "otype" : "Author", "mtid" : 10001677, "link" : "/api/author/10001677", "label" : "Berényi Sándor Zsolt (Szerves kémia)", "familyName" : "Berényi", "givenName" : "Sándor Zsolt", "published" : true, "oldId" : 10001677, "snippet" : true }, "familyName" : "Berenyi", "givenName" : "S", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 10829157, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 825334, "link" : "/api/authorship/825334", "label" : "Vonk, A", "listPosition" : 3, "share" : 0.2, "first" : false, "last" : false, "familyName" : "Vonk", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 10829156, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 825335, "link" : "/api/authorship/825335", "label" : "Rinken, A", "listPosition" : 4, "share" : 0.2, "first" : false, "last" : false, "familyName" : "Rinken", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 10829155, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 825336, "link" : "/api/authorship/825336", "label" : "Sipos, A [Sipos, Attila (Gyógyszerészi kémia), szerző] Gyógyszerésztudományi Kar (DE)", "listPosition" : 5, "share" : 0.2, "first" : false, "last" : true, "author" : { "otype" : "Author", "mtid" : 10018223, "link" : "/api/author/10018223", "label" : "Sipos Attila (Gyógyszerészi kémia)", "familyName" : "Sipos", "givenName" : "Attila", "published" : true, "oldId" : 10018223, "snippet" : true }, "familyName" : "Sipos", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 10829154, "snippet" : true } ], "title" : "N-Substituted-2-alkyl- and 2-arylnorapomorphines: Novel, highly active D-2 agonists", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 233144, "link" : "/api/publicationidentifier/233144", "label" : "DOI: 10.1016/j.bmc.2009.04.047", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "oaFree" : false, "validState" : "NO", "idValue" : "10.1016/j.bmc.2009.04.047", "realUrl" : "https://doi.org/10.1016/j.bmc.2009.04.047", "published" : false, "oldId" : 111595, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 233143, "link" : "/api/publicationidentifier/233143", "label" : "WoS: 000266822900053", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "000266822900053", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000266822900053", "published" : false, "oldId" : 111596, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 16550057, "link" : "/api/publicationidentifier/16550057", "label" : "DEA: 97378", "source" : { "otype" : "PlainSource", "mtid" : 38, "link" : "/api/publicationsource/38", "label" : "DEA", "type" : { "otype" : "PublicationSourceType", "mtid" : 10007, "link" : "/api/publicationsourcetype/10007", "label" : "Repozitórium", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DEA", "linkPattern" : "http://hdl.handle.net/2437/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 38, "snippet" : true }, "oaType" : "CLOSED", "validState" : "IDENTICAL", "idValue" : "97378", "realUrl" : "http://hdl.handle.net/2437/97378", "published" : true, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 14821414, "link" : "/api/publicationidentifier/14821414", "label" : "Scopus: 66449100027", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "NO", "idValue" : "66449100027", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-66449100027", "published" : false, "oldId" : 1926247, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 15041997, "link" : "/api/publicationidentifier/15041997", "label" : "PubMed: 19454369", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "validState" : "NO", "idValue" : "19454369", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19454369&dopt=Abstract", "published" : false, "oldId" : 4467505, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 11300, "link" : "/api/journal/11300", "label" : "BIOORGANIC & MEDICINAL CHEMISTRY 0968-0896 1464-3391", "pIssn" : "0968-0896", "eIssn" : "1464-3391", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 11300, "snippet" : true }, "volume" : "17", "issue" : "13", "firstPage" : "4756", "lastPage" : "4762", "firstPageOrInternalIdForSort" : "4756", "pageLength" : 7, "publishedYear" : 2009, "abstractText" : "Two synthesis routes have been elaborated for the preparation of novel N-substituted-2-alkyl- and 2-arylnorapomorphines. The first one utilizes the traditional methodology of N-substitution of morphinans before acid-catalyzed rearrangements into aporphinoids, while our new approach involves the N-substitution directly on the aporphine backbone. The aimed compounds were obtained in similar overall yields in different synthesis routes and were investigated with respect to their binding affinities and activities to dopamine D-2 and D-1 receptors. These studies revealed remarkable affinity and selectivity of some compounds for D-2 over D-1 receptor subtypes. Partial or full agonist properties were confirmed for all tested compounds. (C) 2009 Elsevier Ltd. All rights reserved.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10545, "link" : "/api/classification/10545", "label" : "Biológiai tudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 10293, "link" : "/api/classification/10293", "label" : "Kémiai tudományok", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2009, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "CLOSED", "oaCheckDate" : "2024-02-15", "oaFree" : false, "citationCount" : 12, "citationCountUnpublished" : 0, "citationCountWoOther" : 12, "independentCitCountWoOther" : 9, "nationalOriginCitationCount" : 2, "foreignEditionCitationCount" : 12, "doiCitationCount" : 11, "wosCitationCount" : 12, "scopusCitationCount" : 8, "wosScopusCitationCount" : 12, "wosScopusCitationCountWoOther" : 12, "wosScopusIndependentCitationCount" : 9, "wosScopusIndependentCitationCountWoOther" : 9, "independentCitationCount" : 9, "selfCitationCount" : 3, "unhandledCitationCount" : 0, "citingPubCount" : 12, "independentCitingPubCount" : 9, "citingPubCountWoOther" : 12, "independentCitingPubCountWoOther" : 9, "unhandledCitingPubCount" : 0, "citedPubCount" : 8, "citedCount" : 8, "pubStats" : { "types" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "count" : 12 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "count" : 0 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "count" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "count" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "count" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "count" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "count" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "count" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "count" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "count" : 0 } ], "citationTypes" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 } ], "years" : [ { "year" : 2010, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 1, "citingPubCount" : 2, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2011, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 0, "citingPubCount" : 1, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2012, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2013, "publicationCount" : 0, "citationCount" : 3, "independentCitationCount" : 2, "citingPubCount" : 3, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null }, { "year" : 2014, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2015, "publicationCount" : 0, "citationCount" : 3, "independentCitationCount" : 3, "citingPubCount" : 3, "independentCitingPubCount" : 3, "oaStats" : null, "oaStats2" : null }, { "year" : 2016, "publicationCount" : 0, "citationCount" : 0, "independentCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2017, "publicationCount" : 0, "citationCount" : 0, "independentCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2018, "publicationCount" : 0, "citationCount" : 0, "independentCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2019, "publicationCount" : 0, "citationCount" : 0, "independentCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2020, "publicationCount" : 0, "citationCount" : 0, "independentCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2021, "publicationCount" : 0, "citationCount" : 0, "independentCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2022, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null } ] }, "ratings" : [ { "otype" : "SjrRating", "mtid" : 5786736, "link" : "/api/sjrrating/5786736", "label" : "sjr:Q1 (2009) Scopus - Clinical Biochemistry BIOORGANIC & MEDICINAL CHEMISTRY 0968-0896 1464-3391", "listPos" : 27, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1308, "link" : "/api/classificationexternal/1308", "label" : "Scopus - Clinical Biochemistry", "published" : true, "oldId" : 1308, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "oldId" : 5786736, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2009-12-16T15:12:51.000+0000", "publishDate" : "2013-02-23T19:18:00.000+0000", "directInstitutesForSort" : "Gyógyszerésztudományi Kar (DE); Szerves Kémiai Tanszék (DE / TTK / KemI)", "ownerAuthorCount" : 2, "ownerInstituteCount" : 8, "directInstituteCount" : 2, "authorCount" : 5, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/1256956", "label" : "Herm L et al. N-Substituted-2-alkyl- and 2-arylnorapomorphines: Novel, highly active D-2 agonists. (2009) BIOORGANIC & MEDICINAL CHEMISTRY 0968-0896 1464-3391 17 13 4756-4762", "template" : "