{ "labelLang" : "hun", "responseDate" : "2024-03-29 15:25", "content" : { "otype" : "JournalArticle", "mtid" : 1250914, "status" : "VALIDATED", "published" : true, "comment" : "Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, United States \n Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298-0709, United States \n Cited By :179 \n Export Date: 1 February 2024 \n CODEN: JNEUE \n Correspondence Address: Povlishock, J.T.; Department of Anatomy, , Richmond, VA 23298-0709, United States; email: jpovlish@hsc.vcu.edu", "unhandledTickets" : 0, "oldTimestamp" : "2016-07-15T10:49:32.000+0000", "deleted" : false, "oldId" : 1250914, "lastRefresh" : "2024-02-20T12:33:31.908+0000", "lastModified" : "2023-09-02T13:45:08.698+0000", "created" : "2009-08-27T22:00:00.000+0000", "creator" : { "otype" : "Author", "mtid" : 10002667, "link" : "/api/author/10002667", "label" : "Büki András (Idegsebészet, idegtudományok)", "familyName" : "Büki", "givenName" : "András", "published" : true, "oldId" : 10002667, "snippet" : true }, "lastDuplumSearch" : "2024-02-06T08:42:59.252+0000", "validated" : "2023-09-02T13:45:08.984+0000", "validator" : { "otype" : "Admin", "mtid" : 10039043, "link" : "/api/admin/10039043", "label" : "Milánkovics Róbert (PTE ÁOK admin 4)", "familyName" : "Milánkovics", "givenName" : "Róbert", "published" : true, "oldId" : 10039043, "snippet" : true }, "core" : true, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 10000059, "link" : "/api/subtype/10000059", "label" : "Szakcikk (Folyóiratcikk)", "name" : "Szakcikk", "nameEng" : "Article", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 101, "published" : true, "oldId" : 10000059, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Buki, A", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 814677, "link" : "/api/authorship/814677", "label" : "Buki, A [Büki, András (Idegsebészet, ide...), szerző] Idegsebészeti Klinika (PTE / ÁOK)", "listPosition" : 1, "share" : 0.33333334, "first" : true, "last" : false, "author" : { "otype" : "Author", "mtid" : 10002667, "link" : "/api/author/10002667", "label" : "Büki András (Idegsebészet, idegtudományok)", "familyName" : "Büki", "givenName" : "András", "published" : true, "oldId" : 10002667, "snippet" : true }, "familyName" : "Buki", "givenName" : "A", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 10812127, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 814678, "link" : "/api/authorship/814678", "label" : "Okonkwo, DO", "listPosition" : 2, "share" : 0.33333334, "first" : false, "last" : false, "familyName" : "Okonkwo", "givenName" : "DO", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 10812126, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 814679, "link" : "/api/authorship/814679", "label" : "Povlishock, JT ✉", "listPosition" : 3, "share" : 0.333, "first" : false, "last" : true, "corresponding" : true, "familyName" : "Povlishock", "givenName" : "JT", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 10812125, "snippet" : true } ], "title" : "Postinjury cyclosporin a administration limits axonal damage and disconnection in traumatic brain injury.", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 230166, "link" : "/api/publicationidentifier/230166", "label" : "DOI: 10.1089/neu.1999.16.511", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "10.1089/neu.1999.16.511", "realUrl" : "https://doi.org/10.1089/neu.1999.16.511", "published" : false, "oldId" : 110073, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 230164, "link" : "/api/publicationidentifier/230164", "label" : "WoS: 000080879800007", "source" : { "otype" : "PlainSource", "mtid" : 1, "link" : "/api/publicationsource/1", "label" : "WoS", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "WoS", "nameEng" : "WoS", "linkPattern" : "https://www.webofscience.com/wos/woscc/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 1, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "000080879800007", "realUrl" : "https://www.webofscience.com/wos/woscc/full-record/000080879800007", "published" : false, "oldId" : 110074, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 230165, "link" : "/api/publicationidentifier/230165", "label" : "Scopus: 0345379310", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "0345379310", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0345379310", "published" : false, "oldId" : 442389, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 230167, "link" : "/api/publicationidentifier/230167", "label" : "PubMed: 10391367", "source" : { "otype" : "PlainSource", "mtid" : 17, "link" : "/api/publicationsource/17", "label" : "PubMed", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "PubMed", "nameEng" : "PubMed", "linkPattern" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract", "publiclyVisible" : true, "published" : true, "oldId" : 17, "snippet" : true }, "oaFree" : false, "validState" : "IDENTICAL", "idValue" : "10391367", "realUrl" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10391367&dopt=Abstract", "published" : false, "oldId" : 110075, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 2712, "link" : "/api/journal/2712", "label" : "JOURNAL OF NEUROTRAUMA 0897-7151 1557-9042", "pIssn" : "0897-7151", "eIssn" : "1557-9042", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 2712, "snippet" : true }, "volume" : "16", "issue" : "6", "firstPage" : "511", "lastPage" : "521", "firstPageOrInternalIdForSort" : "511", "pageLength" : 11, "publishedYear" : 1999, "abstractText" : "Recent observations concerning presumed calcium-induced mitochondrial damage and \nfocal intraaxonal proteolysis in the pathogenesis of traumatic axonal injury\n(TAI) have opened new perspectives for therapeutic intervention. Studies from our\nlaboratory demonstrated that cyclosporin A (CsA), a potent inhibitor of\nCa2+-induced mitochondrial damage, administered 30 min prior to traumatic brain\ninjury preserved mitochondrial integrity in those axonal foci destined to undergo\ndelayed disconnection. We attributed this neuroprotection to the inhibition by\nCsA of mitochondrial permeability transition (MPT). Additional experiments proved\nthat CsA pretreatment also significantly reduced calcium-induced,\ncalpain-mediated spectrin proteolysis (CMSP) and neurofilament compaction (NFC), \npivotal events in the pathogenesis of axonal failure and disconnection. Given\nthese provocative findings the goal of the current study was to evaluate the\npotential of CsA to inhibit calcium-induced axonal damage in a more clinically\nrelevant postinjury treatment paradigm. To this end, cyclosporin A was\nadministered intrathecally to Sprague Dawley rats 30 min following impact\nacceleration traumatic brain injury. The first group of animals were sacrificed\n120 min postinjury and the density of CMSP and NFC immunoreactive damaged axonal \nsegments of CsA-treated and vehicle-treated injured animals were quantitatively\nanalyzed. A second group of CsA- versus vehicle-treated rats was sacrificed at 24\nh postinjury to compare the density of damaged axons displaying beta amyloid\nprecursor protein (APP) immunoreactivity, a signature protein of axonal\nperturbation and disconnection. Postinjury CsA administration resulted in a\nsignificant decrease (>60%) in CMSP/NFC immunoreactivity in corticospinal tracts \nand medial longitudinal fasciculi. A similar decrease was detected in the density\nof APP immunoreactive damaged axons, indicating an attenuation of axonal\ndisconnection at 24 h postinjury in CsA-treated animals. These results once again\nsuggest that the maintenance of the functional integrity of the mitochondria can \nprevent TAI, presumably via the preservation of the local energy homeostasis of\nthe axon. Moreover and perhaps more importantly, these studies also demonstrate\nthe efficacy of CsA administration when given in the early posttraumatic period. \nCollectively, our findings suggest that a therapeutic window exists for the use\nof drugs targeting mitochondria and energy regulation in traumatic brain injury.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Általános orvostudomány", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Klinikai orvostan", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2009, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2024-02-20", "oaFree" : false, "oaByAuthor" : { "otype" : "Admin", "mtid" : 10022754, "link" : "/api/admin/10022754", "label" : "Milánkovics Róbert (PTE ÁOK admin 5)", "familyName" : "Milánkovics", "givenName" : "Róbert", "published" : true, "oldId" : 10022754, "snippet" : true }, "citationCount" : 187, "citationCountUnpublished" : 0, "citationCountWoOther" : 185, "independentCitCountWoOther" : 155, "nationalOriginCitationCount" : 11, "foreignEditionCitationCount" : 180, "doiCitationCount" : 170, "wosCitationCount" : 171, "scopusCitationCount" : 182, "wosScopusCitationCount" : 185, "wosScopusCitationCountWoOther" : 185, "wosScopusIndependentCitationCount" : 155, "wosScopusIndependentCitationCountWoOther" : 155, "independentCitationCount" : 157, "selfCitationCount" : 30, "unhandledCitationCount" : 0, "citingPubCount" : 187, "independentCitingPubCount" : 157, "citingPubCountWoOther" : 185, "independentCitingPubCountWoOther" : 155, "unhandledCitingPubCount" : 0, "citedPubCount" : 3, "citedCount" : 3, "pubStats" : { "types" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "count" : 175 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "count" : 10 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "count" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "count" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "count" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "count" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "count" : 2 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "count" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "count" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "count" : 0 } ], "citationTypes" : [ { "type" : "Folyóiratcikk", "typeEng" : "Journal Article", "code" : 24, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyvrészlet", "typeEng" : "Chapter in Book", "code" : 25, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Könyv", "typeEng" : "Book", "code" : 23, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciaközlemény", "typeEng" : "Conference paper", "code" : 31, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb konferenciakötet", "typeEng" : "Conference proceedings", "code" : 32, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Oltalmi formák", "typeEng" : "Protection forms", "code" : 26, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Disszertáció", "typeEng" : "Thesis", "code" : 28, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Egyéb", "typeEng" : "Miscellaneous", "code" : 29, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Alkotás", "typeEng" : "Achievement", "code" : 22, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 }, { "type" : "Kutatási adat", "typeEng" : "Research data", "code" : 33, "countUnknown" : 0, "countIndependent" : 0, "countSelfCitation" : 0 } ], "years" : [ { "year" : 1999, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 0, "citingPubCount" : 1, "independentCitingPubCount" : 0, "oaStats" : null, "oaStats2" : null }, { "year" : 2000, "publicationCount" : 0, "citationCount" : 11, "independentCitationCount" : 8, "citingPubCount" : 11, "independentCitingPubCount" : 8, "oaStats" : null, "oaStats2" : null }, { "year" : 2001, "publicationCount" : 0, "citationCount" : 13, "independentCitationCount" : 10, "citingPubCount" : 13, "independentCitingPubCount" : 10, "oaStats" : null, "oaStats2" : null }, { "year" : 2002, "publicationCount" : 0, "citationCount" : 9, "independentCitationCount" : 8, "citingPubCount" : 9, "independentCitingPubCount" : 8, "oaStats" : null, "oaStats2" : null }, { "year" : 2003, "publicationCount" : 0, "citationCount" : 15, "independentCitationCount" : 11, "citingPubCount" : 15, "independentCitingPubCount" : 11, "oaStats" : null, "oaStats2" : null }, { "year" : 2004, "publicationCount" : 0, "citationCount" : 19, "independentCitationCount" : 16, "citingPubCount" : 19, "independentCitingPubCount" : 16, "oaStats" : null, "oaStats2" : null }, { "year" : 2005, "publicationCount" : 0, "citationCount" : 7, "independentCitationCount" : 5, "citingPubCount" : 7, "independentCitingPubCount" : 5, "oaStats" : null, "oaStats2" : null }, { "year" : 2006, "publicationCount" : 0, "citationCount" : 14, "independentCitationCount" : 11, "citingPubCount" : 14, "independentCitingPubCount" : 11, "oaStats" : null, "oaStats2" : null }, { "year" : 2007, "publicationCount" : 0, "citationCount" : 11, "independentCitationCount" : 10, "citingPubCount" : 11, "independentCitingPubCount" : 10, "oaStats" : null, "oaStats2" : null }, { "year" : 2008, "publicationCount" : 0, "citationCount" : 7, "independentCitationCount" : 6, "citingPubCount" : 7, "independentCitingPubCount" : 6, "oaStats" : null, "oaStats2" : null }, { "year" : 2009, "publicationCount" : 0, "citationCount" : 7, "independentCitationCount" : 6, "citingPubCount" : 7, "independentCitingPubCount" : 6, "oaStats" : null, "oaStats2" : null }, { "year" : 2010, "publicationCount" : 0, "citationCount" : 6, "independentCitationCount" : 4, "citingPubCount" : 6, "independentCitingPubCount" : 4, "oaStats" : null, "oaStats2" : null }, { "year" : 2011, "publicationCount" : 0, "citationCount" : 8, "independentCitationCount" : 7, "citingPubCount" : 8, "independentCitingPubCount" : 7, "oaStats" : null, "oaStats2" : null }, { "year" : 2012, "publicationCount" : 0, "citationCount" : 15, "independentCitationCount" : 14, "citingPubCount" : 15, "independentCitingPubCount" : 14, "oaStats" : null, "oaStats2" : null }, { "year" : 2013, "publicationCount" : 0, "citationCount" : 7, "independentCitationCount" : 6, "citingPubCount" : 7, "independentCitingPubCount" : 6, "oaStats" : null, "oaStats2" : null }, { "year" : 2014, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 2, "citingPubCount" : 2, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null }, { "year" : 2015, "publicationCount" : 0, "citationCount" : 5, "independentCitationCount" : 4, "citingPubCount" : 5, "independentCitingPubCount" : 4, "oaStats" : null, "oaStats2" : null }, { "year" : 2016, "publicationCount" : 0, "citationCount" : 9, "independentCitationCount" : 8, "citingPubCount" : 9, "independentCitingPubCount" : 8, "oaStats" : null, "oaStats2" : null }, { "year" : 2017, "publicationCount" : 0, "citationCount" : 7, "independentCitationCount" : 7, "citingPubCount" : 7, "independentCitingPubCount" : 7, "oaStats" : null, "oaStats2" : null }, { "year" : 2018, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null }, { "year" : 2019, "publicationCount" : 0, "citationCount" : 3, "independentCitationCount" : 3, "citingPubCount" : 3, "independentCitingPubCount" : 3, "oaStats" : null, "oaStats2" : null }, { "year" : 2020, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 2, "citingPubCount" : 2, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null }, { "year" : 2021, "publicationCount" : 0, "citationCount" : 5, "independentCitationCount" : 5, "citingPubCount" : 5, "independentCitingPubCount" : 5, "oaStats" : null, "oaStats2" : null }, { "year" : 2022, "publicationCount" : 0, "citationCount" : 2, "independentCitationCount" : 2, "citingPubCount" : 2, "independentCitingPubCount" : 2, "oaStats" : null, "oaStats2" : null }, { "year" : 2023, "publicationCount" : 0, "citationCount" : 1, "independentCitationCount" : 1, "citingPubCount" : 1, "independentCitingPubCount" : 1, "oaStats" : null, "oaStats2" : null } ] }, "ratings" : [ { "otype" : "SjrRating", "mtid" : 6179483, "link" : "/api/sjrrating/6179483", "label" : "sjr:Q1 (1999) Scopus - Neurology (clinical) JOURNAL OF NEUROTRAUMA 0897-7151", "listPos" : 24, "rankValue" : 0.24, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2728, "link" : "/api/classificationexternal/2728", "label" : "Scopus - Neurology (clinical)", "published" : true, "oldId" : 2728, "snippet" : true }, "ranking" : "Q1", "calculation" : "DIRECT", "published" : true, "oldId" : 6179483, "snippet" : true } ], "ratingsForSort" : "Q1", "hasCitationDuplums" : false, "userChangeableUntil" : "2016-07-15T10:49:32.000+0000", "publishDate" : "2012-11-15T20:25:28.000+0000", "directInstitutesForSort" : "Idegsebészeti Klinika (PTE / ÁOK)", "ownerAuthorCount" : 1, "ownerInstituteCount" : 10, "directInstituteCount" : 1, "authorCount" : 3, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/1250914", "label" : "Buki A et al. Postinjury cyclosporin a administration limits axonal damage and disconnection in traumatic brain injury.. (1999) JOURNAL OF NEUROTRAUMA 0897-7151 1557-9042 16 6 511-521", "template" : "