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Detectable interactions between NOEL (No Observed Effect Level) doses of Pb, Hg and Cd in general toxicological, hematological, and immune function parameters were investigated. The metals (Pb-acetate, 20 mg/kg; HgCl 2, 0.40 mg/kg; CdCl2, 1.61 mg/kg) were combined. First, the rats received the combination Pb + Hg + Cd for 4 weeks per os. Significant difference vs. control was found only in the weight of lung and popliteal lymph node (PLN). The Pb + Hg and Pb + Cd combinations significantly decreased the PLN to 100 g body weight and PLN to brain weight ratio, and Pb+Hg also decreased the relative adrenal weight. After 12 weeks treatment with the same doses, effects on the thymus, kidney, and adrenal weights in the Pb + Hg, and thymus weight in the Pb + Cd, combination were seen. Pb + Cd also affected the white and red blood cell count and hematocrit. Combined with Hg or Cd, NOEL dose Pb showed toxicity, indicating that exposure limits may be inefficient in combined exposure situations. Š 2006 AkadÊmiai Kiadó.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10010120"> <a href="/gui2/?type=authors&mode=browse&sel=10010120" target="_blank">Institóris, L ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Kovács, D </span> <span class="author-type"> </span> ; <span class="author-name" > Kecskeméti-Kovács, I </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10028688"> <a href="/gui2/?type=authors&mode=browse&sel=10028688" target="_blank">Lukács, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10028691"> <a href="/gui2/?type=authors&mode=browse&sel=10028691" target="_blank">Szabó, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Lengyel, Z </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10002560"> <a href="/gui2/?type=authors&mode=browse&sel=10002560" target="_blank">Papp, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10010104"> <a href="/gui2/?type=authors&mode=browse&sel=10010104" target="_blank">Nagymajtényi, L</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10007465"> <a href="/gui2/?type=authors&mode=browse&sel=10007465" target="_blank">Dési, I</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1240513" mtid="1240513" target="_blank">Immunotoxicological investigation of subacute combined exposure with low doses of pb, hg and cd in rats</a></div> <div class="pub-info"> <span class="journal-title">ACTA BIOLOGICA HUNGARICA (1983-2018)</span> <span class="journal-volume">57</span> : <span class="journal-issue">4</span> <span class="page"> pp. 433-439. , 7 p. </span> <span class="year">(2006)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1556/ABiol.57.2006.4.5" target="_blank" href="https://doi.org/10.1556/ABiol.57.2006.4.5"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="6451" target="_blank" href="http://real.mtak.hu/6451"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000242018400005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000242018400005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33750987632" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-33750987632"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="17278705" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17278705&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="27638" target="_blank" href="http://publicatio.bibl.u-szeged.hu/27638"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Publication:1240513 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Validated </span></span> <span class="pub-core">Core Citing </span> <span class="pub-type">Journal Article (Article ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Scientific</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 14</span> | Independent citation: 14 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 12 | Number of citations in Scopus: 9 | WoS/Scopus assigned: 13 | Number of citations with DOI: 14 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10010120"><a href="/gui2/?type=authors&mode=browse&sel=10010120" target="_blank">Institóris L ✉ (<span class="authorship-author-name">Institóris László</span> <span class="authorAux-mtmt"> Igazságügyi toxikológia</span>) </a> </span> ; 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<span class="author-name" mtid="10010104"><a href="/gui2/?type=authors&mode=browse&sel=10010104" target="_blank">Nagymajtényi L (<span class="authorship-author-name">Nagymajtényi László</span> <span class="authorAux-mtmt"> Neurotoxikológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Public Health</span> ; <span class="author-name" mtid="10007465"><a href="/gui2/?type=authors&mode=browse&sel=10007465" target="_blank">Dési I (<span class="authorship-author-name">Dési Illés</span> <span class="authorAux-mtmt"> Közegészségtan, toxikológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Public Health</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;1240513" target="_blank">Immunotoxicological investigation of subacute combined exposure with low doses of pb, hg and cd in rats</a></div> <div> <span class="journal-title">ACTA BIOLOGICA HUNGARICA (1983-2018)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0236-5383">0236-5383</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1588-256X">1588-256X</a>)</span>: <span class="journal-volume">57</span> <span class="journal-issue">4</span> <span class="page"> pp 433-439 </span> <span class="year">(2006)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1556/ABiol.57.2006.4.5" target="_blank" href="https://doi.org/10.1556/ABiol.57.2006.4.5"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="6451" target="_blank" href="http://real.mtak.hu/6451"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000242018400005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000242018400005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33750987632" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-33750987632"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="17278705" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17278705&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="27638" target="_blank" href="http://publicatio.bibl.u-szeged.hu/27638"> SZTE Publicatio </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 14</span> | Independent citation: 14 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 12 | Number of citations in Scopus: 9 | WoS/Scopus assigned: 13 | Number of citations with DOI: 14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1240513&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 1240513</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 1240513</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2023.06.27. 13:46 Fruzsina Szalai (SZTE admin5) </div> </div></div>