https://m2.mtmt.hu/ hun 2026-05-01 03:49 JournalArticle 1239209 APPROVED true ECASS Multicenter Study 154 Collaborators The European Cooperative Acute Stroke Study (ECASS) investigators are as follows: Steering Committee — W. Hacke (chair), A. Dávalos, M. Kaste, R. von Kummer, V. Larrue, D. Toni, N. Wahlgren; Data and Safety Monitoring Board — K.R. Lees (chair), W.D. Heiss, E. Lesaffre, J.M. Orgogozo; Safety Outcome Adjudication Committee — R. von Kummer (chair), S. Bastianello, J.M. Wardlaw; Statisticians — J.-C. Peyrieux (STATMED, Lyon, France), C. Sauce (Boehringer Ingelheim); Trial Management Team at Boehringer Ingelheim — Z. Medeghri, R. Mazenc, C. Sauce, T. Machnig, E. Bluhmki; principal investigators (with the number of patients enrolled given in parentheses) — Austria (53): F. Aichner, C. Alf, U. Baumhackl, M. Brainin, C. Eggers, F. Gruber, G. Ladurner, K. Niederkorn, G. Noistering, J. Willeit; Belgium (22): G. Vanhooren (national coordinator), S. Blecic, B. Bruneel, J. Caekebeke, P. Laloux, P.J. Simons, V. Thijs; Czech Republic (18): M. Bar, H. Dvorakova, D. Vaclavik; Denmark (44): G. Boysen (national coordinator), G. Andersen, H.K. Iversen, B. Traberg-Kristensen; Finland (15): M. Kaste (national coordinator), R. Marttila, J. Sivenius; France (104): P. Trouillas (national coordinator), P. Amarenco, J. Bouillat, X. Ducrocq, M. Giroud, A. Jaillard, J.-M. Larrieu, V. Larrue, D. Leys, C. Magne, M.-H. Mahagne, D. Milhaud, D. Sablot, D. Saudeau; Germany (130): O. Busse (national coordinator), J. Berrouschot, J.H. Faiss, J. Glahn, M. Görtler, A. Grau, M. Grond, R. Haberl, G. Hamann, M. Hennerici, H. Koch, P. Krauseneck, J. Marx, S. Meves, U. Meyding-Lamadé, P. Ringleb, D. Schneider, A. Schwarz, J. Sobesky, P. Urban; Greece (2): K. Karageorgiou (national coordinator), A. Komnos; Hungary (9): A. Csányi, L. Csiba, A. Valikovics; Italy (147): D. Toni (national coordinator), G. Agnelli, G. Billo, P. Bovi, G. Comi, G. Gigli, D. Guidetti, D. Inzitari, N. Marcello, C. Marini, G. Orlandi, M. Pratesi, M. Rasura, A. Semplicini, C. Serrati, T. Tassinari; the Netherlands (5): P.J.A.M. Brouwers (national coordinator), J. Stam (national coordinator); Norway (14): H. Naess (national coordinator), B. Indredavik, R. Kloster; Poland (16): A. Czlonkowska (national coordinator), A. Kuczyska-Zardzewialy, W. Nyka, G. Opala, S. Romanowicz; Portugal (13): L. Cunha (national coordinator), C. Correia, V. Cruz, T. Pinho e Melo; Slovakia (59): M. Brozman, M. Dvorak, R. Garay, G. Krastev, E. Kurca; Spain (111): J. Alvarez-Sabin (national coordinator), A. Chamorro, M. del Mar Freijo Guerrero, J.A.E. Herrero, A. Gil- Peralta, R. Leira, J.L. Martí-Vilalta, J. Masjuan Vallejo, M. Millán, C. Molina, E. Mostacero, T. Segura, J. Serena, J. Vivancos Mora; Sweden (14): E. Danielsson (national coordinator), B. Cederin, E. von Zweigberg, N.-G. Wahlgren, L. Welin; Switzerland (23): P. Lyrer (national coordinator), J. Bogousslavsky, H.-J. Hungerbühler, B. Weder; United Kingdom (22): G.A. Ford (national coordinator), D. Jenkinson, M.J. MacLeod, R.S. MacWalter, H.S. Markus, K.W. Muir, A.K. Sharma, M.R. Walters, E.A. Warburton. 0 2014-10-16T16:33:00.000+0000 false 1239209 2026-04-22T08:49:08.976+0000 2020-02-28T07:03:04.344+0000 2009-07-08T22:00:00.000+0000 true 10001064 Admin Bevitel /api/author/10001064 Author false 10001064 2021-11-11T19:22:39.525+0000 2021-11-11T19:22:39.525+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Hacke, W Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 359 13 1317 1329 1317 13 2008 BACKGROUND: Intravenous thrombolysis with alteplase is the only approved treatment for acute ischemic stroke, but its efficacy and safety when administered more than 3 hours after the onset of symptoms have not been established. We tested the efficacy and safety of alteplase administered between 3 and 4.5 hours after the onset of a stroke. METHODS: After exclusion of patients with a brain hemorrhage or major infarction, as detected on a computed tomographic scan, we randomly assigned patients with acute ischemic stroke in a 1:1 double-blind fashion to receive treatment with intravenous alteplase (0.9 mg per kilogram of body weight) or placebo. The primary end point was disability at 90 days, dichotomized as a favorable outcome (a score of 0 or 1 on the modified Rankin scale, which has a range of 0 to 6, with 0 indicating no symptoms at all and 6 indicating death) or an unfavorable outcome (a score of 2 to 6 on the modified Rankin scale). The secondary end point was a global outcome analysis of four neurologic and disability scores combined. Safety end points included death, symptomatic intracranial hemorrhage, and other serious adverse events. RESULTS: We enrolled a total of 821 patients in the study and randomly assigned 418 to the alteplase group and 403 to the placebo group. The median time for the administration of alteplase was 3 hours 59 minutes. More patients had a favorable outcome with alteplase than with placebo (52.4% vs. 45.2%; odds ratio, 1.34; 95% confidence interval [CI], 1.02 to 1.76; P=0.04). In the global analysis, the outcome was also improved with alteplase as compared with placebo (odds ratio, 1.28; 95% CI, 1.00 to 1.65; P<0.05). The incidence of intracranial hemorrhage was higher with alteplase than with placebo (for any intracranial hemorrhage, 27.0% vs. 17.6%; P=0.001; for symptomatic intracranial hemorrhage, 2.4% vs. 0.2%; P=0.008). Mortality did not differ significantly between the alteplase and placebo groups (7.7% and 8.4%, respectively; P=0.68). There was no significant difference in the rate of other serious adverse events. CONCLUSIONS: As compared with placebo, intravenous alteplase administered between 3 and 4.5 hours after the onset of symptoms significantly improved clinical outcomes in patients with acute ischemic stroke; alteplase was more frequently associated with symptomatic intracranial hemorrhage. 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true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000259440900003 https://www.webofscience.com/wos/woscc/full-record/000259440900003 false 9442346 true PublicationIdentifier 224015 /api/publicationidentifier/224015 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 18815396 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18815396&dopt=Abstract false 106214 true SjrRating 5850732 /api/sjrrating/5850732 4 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true 5850732 true /api/publication/1239209 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Hacke W </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kaste M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bluhmki E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brozman M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dávalos A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Guidetti D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Larrue V </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lees KR </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Medeghri Z </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Machnig T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schneider D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >von Kummer R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wahlgren N </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Toni D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >ECASS Investigators </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001064"><a href="/gui2/?type=authors&mode=browse&sel=10001064" target="_blank">Csiba L (<span class="authorship-author-name">Admin Bevitel</span> <span class="authorAux-mtmt"> (központi)</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >et al </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1239209" target="_blank">Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">359</span> <span class="journal-issue">13</span> <span class="page"> pp 1317-1329 </span> <span class="year">(2008)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa0804656" target="_blank" href="https://doi.org/10.1056/NEJMoa0804656"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000259440900003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000259440900003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="18815396" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18815396&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4,706</span> | Független: 4,535 | Függő: 171 | Nem jelölt: 0 | WoS jelölt: 4,706 | Scopus jelölt:&nbsp;1,738 | WoS/Scopus jelölt:&nbsp;4,706 | DOI jelölt:&nbsp;4,541 (Nem nyilvános:&nbsp;10) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1239209&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1239209</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 1239209</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2020.02.28. 08:03 Szuper Admin (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: ECASS Multicenter Study 154 Collaborators The European Cooperative Acute Stroke Study (ECASS) investigators are as follows: Steering Committee — W. Hacke (chair), A. Dávalos, M. Kaste, R. von Kummer, V. Larrue, D. Toni, N. Wahlgren; Data and Safety Monitoring Board — K.R. Lees (chair), W.D. Heiss, E. Lesaffre, J.M. Orgogozo; Safety Outcome Adjudication Committee — R. von Kummer (chair), S....</pre> </div></div>