The concepts and methods of systems biology are extended to neuropharmacology in order
to test and design drugs for the treatment of neurological and psychiatric disorders.
Computational modelling by integrating compartmental neural modelling techniques and
detailed kinetic descriptions of pharmacological modulation of tran smitter-receptor
interaction is offered as a method to test the electrophysiological and behavioural
effects of putative drugs. Even more, an inverse method is suggested as a method for
controlling a neural system to realise a prescribed temporal pattern. In particular,
as an application of the proposed new methodology, a computational platform is offered
to analyse the generation and pharmacological modulation of theta rhythm related to
anxiety.
