https://m2.mtmt.hu/ eng 2026-04-30 05:41 JournalArticle 1228277 VALIDATED true 0 2017-07-14T19:39:32.000+0000 false 1228277 2026-04-21T11:58:55.471+0000 2026-02-12T13:24:58.277+0000 2009-04-19T22:00:00.000+0000 true 10002468 Érdi Péter /api/author/10002468 Author Péter Érdi (Fizikai kémia, matematikai modellek, elméleti neurobiológia) true 10002468 2026-02-12T13:24:58.690+0000 2026-02-12T13:24:58.690+0000 2024-01-23T10:32:20.630+0000 true 10075667 Szabó Emese /api/admin/10075667 Admin Emese Szabó (Wigner admin5) true true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Ujfalussy, B true true /api/journal/3361 REVIEWED NEUROPHARMACOLOGY 0028-3908 1873-7064 true false 3361 false 3361 true 0028-3908 1873-7064 Journal FOREIGN 52 3 733 743 733 11 2007 Clinically most active anxiolytic drugs are positive allosteric modulators (PAMs) of GABAA receptors, represented by benzodiazepine compounds. Due to their non-selective profile, however, they potently modulate several sup-type specific GABAA receptors, contributing to their broad-range side effects. Based on observations in genetically altered mice, however, it has been proposed that anxiolytic action of benzodiazepines is predominantly mediated by GABAA alpha 2/3 subunit-containing receptors. In the present study we analyzed the actions of the preferential GABA(A) alpha 1 and alpha 2/3 PAMs, zolpidem and L-838417, respectively on hippocampal EEG and medial septum neuronal activity in anesthetized rats. In parallel, a computational model was constructed to model pharmacological actions of these compounds on the septo-hippocampal circuitry. The present results demonstrated that zolpidem inhibited theta oscillation both in the hippocampus and septum, and profoundly inhibited firing activity of septal neurons. L-838417 also inhibited hippocampal and septal theta oscillation, however, it did not significantly alter firing rate activity of septal neurons. Our computational model showed that cessation of periodic firing of hippocamposeptal neurons, representing absence of hippocampal theta activity, disrupted oscillation of septal units, without altering their overall firing activity, similar to changes observed in our in vivo experiments following administration of L-838417. Understanding the correlation between changes in septo-hippocampal activity and actions of selective modulators of GABAA subtype receptor modulators would further advance design of anxiolytic drugs. (c) 2006 Elsevier Ltd. All rights reserved. 2009 true true true false false NONE 2026-04-21 false true 10039656 Kmety Andrea /api/admin/10039656 Admin Andrea Kmety (MTA Wigner, admin) true 10039656 14 0 14 9 3 13 12 12 12 13 13 8 8 9 5 0 14 9 14 9 0 11 11 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 1 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2007 0 2 0 2 0 2008 0 1 1 1 1 2009 0 2 1 2 1 2010 0 1 1 1 1 2011 0 1 1 1 1 2012 0 0 0 0 0 2013 0 1 1 1 1 2014 0 2 1 2 1 2015 0 0 0 0 0 2016 0 0 0 0 0 2017 0 1 0 1 0 2018 0 0 0 0 0 2019 0 1 1 1 1 2020 0 1 1 1 1 2021 0 1 1 1 1 D1 false false false false 2017-07-14T19:37:52.000+0000 2013-02-23T19:18:00.000+0000 Biofizikai Önálló Osztály (KFKI RMKI) 4 27 1 6 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 762751 /api/authorship/762751 Ujfalussy, B [Ujfalussy, Balázs Benedek (Idegtudományok), author] Biophysics (KFKI RMKI) 1 0.16666667 true false Author 10017153 /api/author/10017153 Balázs Benedek Ujfalussy (Idegtudományok) Ujfalussy Balázs Benedek true 10017153 true Ujfalussy B true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 10732128 true PersonAuthorship 762752 /api/authorship/762752 Kiss, T [Kiss, Tamás (Elméleti idegtudo...), author] Biophysics (KFKI RMKI) 2 0.16666667 false false Author 10012667 /api/author/10012667 Tamás Kiss (Elméleti idegtudomány) Kiss Tamás true 10012667 true Kiss T true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 10732127 true PersonAuthorship 762753 /api/authorship/762753 Orban, G [Orbán, Gergő (Elméleti neurobio...), author] Biophysics (KFKI RMKI) 3 0.16666667 false false Author 10017138 /api/author/10017138 Gergő Orbán (Elméleti neurobiológia) Orbán Gergő true 10017138 true Orban G true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 10732126 true PersonAuthorship 762754 /api/authorship/762754 Hoffmann, WE 4 0.16666667 false false Hoffmann WE true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 10732125 true PersonAuthorship 762755 /api/authorship/762755 Erdi, P [Érdi, Péter (Fizikai kémia, ma...), author] Biophysics (KFKI RMKI) 5 0.16666667 false false Author 10002468 /api/author/10002468 Péter Érdi (Fizikai kémia, matematikai modellek, elméleti neurobiológia) Érdi Péter true 10002468 true Erdi P true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 10732124 true PersonAuthorship 762756 /api/authorship/762756 Hajos, M 6 0.16666667 false true Hajos M true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 10732123 true PublicationIdentifier 218479 /api/publicationidentifier/218479 DOI: 10.1016/j.neuropharm.2006.09.022 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1016/j.neuropharm.2006.09.022 https://doi.org/10.1016/j.neuropharm.2006.09.022 false 103272 true PublicationIdentifier 218477 /api/publicationidentifier/218477 WoS: 000244962600006 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000244962600006 https://www.webofscience.com/wos/woscc/full-record/000244962600006 false 103273 true PublicationIdentifier 218478 /api/publicationidentifier/218478 Scopus: 33846881808 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 33846881808 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-33846881808 false 103274 true PublicationIdentifier 218481 /api/publicationidentifier/218481 PubMed: 17113111 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 17113111 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17113111&dopt=Abstract false 103275 true Classification 12125 /api/classification/12125 Basic medicine true true Keyword 231 /api/keyword/231 INHIBITION true 231 true Keyword 298 /api/keyword/298 NEURONS true 298 true Keyword 5777 /api/keyword/5777 Hippocampal theta true 5777 true Keyword 5845 /api/keyword/5845 EEG true 5845 true Keyword 5903 /api/keyword/5903 Benzodiazepines true 5903 true Keyword 6452 /api/keyword/6452 MEDIAL SEPTUM true 6452 true Keyword 6463 /api/keyword/6463 DIAZEPAM true 6463 true Keyword 6464 /api/keyword/6464 RECEPTOR SUBTYPES true 6464 true Keyword 6466 /api/keyword/6466 SEPTUM-DIAGONAL BAND true 6466 true Keyword 2622979 /api/keyword/2622979 interneurons true true SjrRating 5899883 /api/sjrrating/5899883 sjr:D1 (2007) Scopus - Pharmacology NEUROPHARMACOLOGY 0028-3908 1873-7064 26 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 3004 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(2007) NEUROPHARMACOLOGY 0028-3908 1873-7064 52 3 733-743<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10017153"><a href="/gui2/?type=authors&mode=browse&sel=10017153" target="_blank">Ujfalussy B (<span class="authorship-author-name">Ujfalussy Balázs Benedek</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="MTA KFKI Institute for Particle and Nuclear Physics">KFKI RMKI</span>/Biophysics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012667"><a href="/gui2/?type=authors&mode=browse&sel=10012667" target="_blank">Kiss T (<span class="authorship-author-name">Kiss Tamás</span> <span class="authorAux-mtmt"> Elméleti idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA KFKI Institute for Particle and Nuclear Physics">KFKI RMKI</span>/Biophysics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017138"><a href="/gui2/?type=authors&mode=browse&sel=10017138" target="_blank">Orban G (<span class="authorship-author-name">Orbán Gergő</span> <span class="authorAux-mtmt"> Elméleti neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA KFKI Institute for Particle and Nuclear Physics">KFKI RMKI</span>/Biophysics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoffmann WE </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002468"><a href="/gui2/?type=authors&mode=browse&sel=10002468" target="_blank">Erdi P (<span class="authorship-author-name">Érdi Péter</span> <span class="authorAux-mtmt"> Fizikai kémia, matematikai modellek, elméleti n...</span>) </a> </span> <span class="author-affil"><span title="MTA KFKI Institute for Particle and Nuclear Physics">KFKI RMKI</span>/Biophysics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hajos M </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1228277" target="_blank">Pharmacological and computational analysis of alpha-subunit preferential GABA(A) positive allosteric modulators on the rat septo-hippocampal activity</a></div> <div> <span class="journal-title">NEUROPHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-3908">0028-3908</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-7064">1873-7064</a>)</span>: <span class="journal-volume">52</span> <span class="journal-issue">3</span> <span class="page"> pp 733-743 </span> <span class="year">(2007)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.neuropharm.2006.09.022" target="_blank" href="https://doi.org/10.1016/j.neuropharm.2006.09.022"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000244962600006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000244962600006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33846881808" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-33846881808"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="17113111" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17113111&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 14</span> | Independent citation: 9 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 12 | Number of citations in Scopus:&nbsp;12 | WoS/Scopus assigned:&nbsp;13 | Number of citations with DOI:&nbsp;12 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1228277&sort=publishedYear,desc&sort=title"> Number of cited publications: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 1228277</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 1228277</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Last Modified: 2026.02.12. 14:24 Emese Szabó (Wigner admin5) </div> </div></div>