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Interactions\nwith animals as pollinators or seed dispersers have long been suspected as drivers of angiosperm diversification, yet\nempirical examples remain sparse or inconclusive. Seed dispersal by ants (myrmecochory) may drive diversification as it can reduce extinction by providing selective advantages to plants and can increase speciation by enhancing geographical\nisolation by extremely limited dispersal distances.\nMethodology/Principal Findings: Using the most comprehensive sister-group comparison to date, we tested the hypothesis that myrmecochory leads to higher diversification rates in angiosperm plants. As predicted, diversification rates\nwere substantially higher in ant-dispersed plants than in their non-myrmecochorous relatives. Data from 101 angiosperm\nlineages in 241 genera from all continents except Antarctica revealed that ant-dispersed lineages contained on average\nmore than twice as many species as did their non-myrmecochorous sister groups. 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