The Influence of Process Parameters on the Size of Chitosan Microspheres Studied by Experimental Design

Biro, E [Biró, Emese (Funkcionális Nano...), szerző]; Nemeth, A Sz [Szemesné Németh, Ágnes (műszaki kémia), szerző]; Sisak, Cs; Feczko, T [Feczkó, Tivadar (Nanotechnológia, ...), szerző]; Gyenis, J [Gyenis, János (Vegyipari művelet...), szerző] Műszaki Kémiai Kutatóintézet (PE / MIK)

Angol nyelvű Tudományos Konferenciaközlemény (Könyvrészlet)
    Azonosítók
    • MTMT: 1161650
    Investigations have been carried out to elucidate the influence of the decision parameters on the particle size of chitosan microspheres intended as support for immobilized enzymes. The chitosan particles were prepared by w/o emulsion crosslinking method by dispersing the aqueous chitosan solution in an oil phase composed of 40 v/v% paraffin oil and 60 v/v% n-octane in the presence of Tween 80 surfactant agent. After emulsification the droplets were hardened by glutaraldehyde crosslinking agent resulting in spherical microparticles. During a series of experiments the speed of stirring applied for emulsification, the concentration of the chitosan, the relative amounts of the surfactant and the glutaraldehyde were varied according to a plan obtained by four factorial three levels experimental design. The depending variable was the mean size of the chitosan microspheres. After evaluating the result of the experiments it was found that the concentration of chitosan, the relative amounts of the surfactant and crosslinking agents had significant influence on the particle size, while surprisingly the stirring rate had only non significant, minor effect.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-10-25 19:56