History of simple febrile seizures is associated with hippocampal abnormalities in adults

Auer, T; Barsi, P [Barsi, Péter (Nanomedicina), szerző]; Bone, B [Bóné, Beáta (Neurológia), szerző] Neurológiai Klinika (PTE / ÁOK); Angyalosi, A [Angyalosi, Anna (Pszichiátria), szerző]; Aradi, M [Aradi, Mihály (Radiologia), szerző]; Szalay, C [Szalay, László Csaba, szerző] Élettani Intézet (PTE / ÁOK); Horvath, R A [Horváth, Réka (Neurológia), szerző]; Kovacs, N [Kovács, Norbert (Klinikai idegtudo...), szerző] Neurológiai Klinika (PTE / ÁOK); Kotek, G; Fogarasi, A [Fogarasi, András (Epileptológia), szerző]; Komoly, S [Komoly, Sámuel (Neurológia), szerző] Neurológiai Klinika (PTE / ÁOK); Janszky, I; Schwarcz, A [Schwarcz, Attila (Mágneses rezonanc...), szerző] Idegsebészeti Klinika (PTE / ÁOK); Janszky, J ✉ [Janszky, József Vladimír (Neurológia), szerző] Neurológiai Klinika (PTE / ÁOK)

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: EPILEPSIA 0013-9580 1528-1167 49 (9) pp. 1562-1569 2008
  • SJR Scopus - Neurology (clinical): D1
Azonosítók
Szakterületek:
    Background: It is unclear whether the hippocampal abnormality in temporal lobe epilepsy (TLE) is a consequence or the cause of afebrile or febrile seizures (FSs). We investigated whether hippocampal abnormalities are present in healthy adults >15 years after a simple FS. Methods: Eight healthy subjects (5 men) with a history of simple FS (FS+ group) and eight sex- and aged-matched control subjects (FS- group) were investigated by three MR methods: blinded visual inspection of the MRI pictures; automatic voxel-based volumetry; and T2 relaxation time measurements. Results: The mean total volume of the two hippocampi was 5.36 ? 1.33 cm3 in the FS+ group and 6.63 ? 1.46 cm3 in the FS- group (p = 0.069). The T2 values in the anterior part of the left hippocampus (p = 0.036) and in the middle part of the right hippocampus (p = 0.025) were elevated in the FS+ subjects. The mean volume of the right hippocampus was 3.05 ? 0.8 cm3 in the FS+ men and 4.05 ? 0.48 cm3 in the FS- men (p = 0.043). The mean total volume of the two hippocampi was 5.38 ? 1.4 cm3 in the FS+ men and 7.48 ? 1.14 cm3 in the FS- men (p = 0.043). There were three FS+ men in whom hippocampal abnormalities including hippocampal sclerosis (HS) and dysgenesis were observed on visual inspection. Conclusions: A history of simple FS in childhood can be associated with hippocampal abnormalities in adults. These abnormalities are probably more pronounced in men. Simple FS may not be as a benign event as previously thought. Our findings suggest that hippocampal abnormalities associated with FS are not necessarily epileptogenic. ? 2008 International League Against Epilepsy.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-10-16 18:21