https://m2.mtmt.hu/ eng 2026-05-25 00:57 JournalArticle 1138671 VALIDATED true 0 2018-09-27T07:26:27.000+0000 false 1138671 2026-05-13T10:24:40.569+0000 2026-01-15T12:27:12.881+0000 2008-11-12T23:00:00.000+0000 true 10019106 Rákosy Zsuzsa /api/author/10019106 Author true 10019106 2026-04-24T05:40:00.826+0000 2026-04-24T05:40:00.826+0000 2026-01-15T12:27:13.065+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Rakosy, Z Characterization of 9p21 copy number alterations in human melanoma by fluorescence in situ hybridization. true true /api/journal/906 REVIEWED true false 906 false 906 true 0165-4608 1873-4456 Journal FOREIGN 182 2 116 121 116 6 2008 Alteration of the CDKN2A (alias p16) tumor suppressor gene, located on 9p21, occurs frequently in familial and sporadic melanomas. Beside CDKN2A, other genes (e.g., CDKN2B, and ARF/p14(ARF), long considered distinct from CDKN2A) on this locus are often deleted or mutated in a large number of tumors including glioma, bladder cancer, and lung cancer. The aim of this study was to evaluate the deletion pattern of the 9p21 locus on a cell-by-cell basis in a large number of melanoma samples using fluorescence in situ hybridization (FISH). In an analysis of 81 primary lesions targeting the 9p21 region and chromosome 9 centromere, high frequency of 9p21 loss (84%) was found. Deletion of 9p21 was present in both early- and late-stage melanomas with similar frequencies. Extra 9p21 copies were rarely seen; they were always associated with polysomy 9 and were observed only in advanced stage melanomas (6 tumors). This FISH study strengthens the hypothesis that the loss of 9p21 occurs frequently in primary melanoma, that the deletion is present in early and late stages of the disease with similar frequency, and that it affects a large extent of the locus. 2008 true true true false true false CLOSED 2026-05-13 false 24 0 24 19 5 22 22 22 23 24 24 19 19 19 5 0 24 19 24 19 0 1 1 Folyóiratcikk Journal Article 24 23 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2008 0 1 1 1 1 2009 0 1 1 1 1 2010 0 4 4 4 4 2011 0 1 1 1 1 2012 0 3 2 3 2 2013 0 2 1 2 1 2014 0 2 2 2 2 2015 0 2 0 2 0 2016 0 2 2 2 2 2017 0 0 0 0 0 2018 0 1 1 1 1 2019 0 0 0 0 0 2020 0 0 0 0 0 2021 0 1 0 1 0 2022 0 0 0 0 0 2023 0 0 0 0 0 2024 0 3 3 3 3 2025 0 1 1 1 1 Q3 false 10019106 false false false 2015-11-19T13:56:42.000+0000 2013-01-08T11:22:07.000+0000 Bőrgyógyászati Tanszék (DE / ÁOK); MTA-DE Népegészségügyi Kutatócsoport (DE / ÁOK / NegJtI); Megelőző Orvostani Intézet (DE / NK) 6 46 3 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 608854 /api/authorship/608854 1 0.14285715 true false Author 10019106 /api/author/10019106 Rákosy Zsuzsa true 10019106 true Rakosy Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10490613 true PersonAuthorship 608855 /api/authorship/608855 2 0.14285715 false false Author 10034960 /api/author/10034960 Vízkeleti Laura true 10034960 true Vizkeleti L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10490612 true PersonAuthorship 608856 /api/authorship/608856 3 0.14285715 false false Author 10020957 /api/author/10020957 Ecsedi Szilvia true 10020957 true Ecsedi S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10490611 true PersonAuthorship 608857 /api/authorship/608857 4 0.14285715 false false Begany A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10490610 true PersonAuthorship 608858 /api/authorship/608858 5 0.14285715 false false Author 10029732 /api/author/10029732 Emri Gabriella true 10029732 true Emri G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10490609 true PersonAuthorship 608859 /api/authorship/608859 6 0.14285715 false false Author 1131057 /api/author/1131057 Ádány Róza true 1131057 true Adany R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10490608 true PersonAuthorship 608860 /api/authorship/608860 7 0.143 false true true Author 10000801 /api/author/10000801 Balázs Margit true 10000801 true Balazs M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10490607 true PublicationIdentifier 183805 /api/publicationidentifier/183805 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1016/j.cancergencyto.2008.01.008 https://doi.org/10.1016/j.cancergencyto.2008.01.008 false 86708 true PublicationIdentifier 183807 /api/publicationidentifier/183807 PlainSource 38 /api/publicationsource/38 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true DEA http://hdl.handle.net/2437/@@@ true true 38 true CLOSED false NO 84212 http://hdl.handle.net/2437/84212 false 616892 true PublicationIdentifier 183803 /api/publicationidentifier/183803 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000255344700007 https://www.webofscience.com/wos/woscc/full-record/000255344700007 false 594487 true PublicationIdentifier 183804 /api/publicationidentifier/183804 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 41749114987 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-41749114987 false 595220 true PublicationIdentifier 183806 /api/publicationidentifier/183806 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 18406873 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18406873&dopt=Abstract false 86709 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true SjrRating 5830636 /api/sjrrating/5830636 90 0.74 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1306 /api/classificationexternal/1306 true 1306 true Q3 DIRECT true 5830636 true /api/publication/1138671 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10019106"><a href="/gui2/?type=authors&mode=browse&sel=10019106" target="_blank">Rakosy Z (<span class="authorship-author-name">Rákosy Zsuzsa</span> <span class="authorAux-mtmt"> Népegészségügy</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Népegészség- és Járványtani Intézet">NegJtI</span>/MTA-DE Public Health Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034960"><a href="/gui2/?type=authors&mode=browse&sel=10034960" target="_blank">Vizkeleti L (<span class="authorship-author-name">Vízkeleti Laura</span> <span class="authorAux-mtmt"> molekuláris biológia, daganat (epi)genomika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Public Health">FPH</span>/Department of Preventive Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020957"><a href="/gui2/?type=authors&mode=browse&sel=10020957" target="_blank">Ecsedi S (<span class="authorship-author-name">Ecsedi Szilvia</span> <span class="authorAux-mtmt"> népegészségügy</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Népegészség- és Járványtani Intézet">NegJtI</span>/MTA-DE Public Health Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Begany A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029732"><a href="/gui2/?type=authors&mode=browse&sel=10029732" target="_blank">Emri G (<span class="authorship-author-name">Emri Gabriella</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Dermatology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1131057"><a href="/gui2/?type=authors&mode=browse&sel=1131057" target="_blank">Adany R (<span class="authorship-author-name">Ádány Róza</span> <span class="authorAux-mtmt"> Népegészségügy, genetikai epidemiológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Népegészség- és Járványtani Intézet">NegJtI</span>/MTA-DE Public Health Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000801"><a href="/gui2/?type=authors&mode=browse&sel=10000801" target="_blank">Balazs M ✉ (<span class="authorship-author-name">Balázs Margit</span> <span class="authorAux-mtmt"> daganatos betegségek, genomika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Népegészség- és Járványtani Intézet">NegJtI</span>/MTA-DE Public Health Research Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1138671" target="_blank">Characterization of 9p21 copy number alterations in human melanoma by fluorescence in situ hybridization.</a></div> <div> <span class="journal-title">CANCER GENETICS AND CYTOGENETICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0165-4608">0165-4608</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-4456">1873-4456</a>)</span>: <span class="journal-volume">182</span> <span class="journal-issue">2</span> <span class="page"> pp 116-121 </span> <span class="year">(2008)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.cancergencyto.2008.01.008" target="_blank" href="https://doi.org/10.1016/j.cancergencyto.2008.01.008"> DOI </a> </span> <span class="id identifier oa_CLOSED" title=" Closed "> <a style="color:black" title="84212" target="_blank" href="http://hdl.handle.net/2437/84212"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000255344700007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000255344700007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41749114987" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-41749114987"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="18406873" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18406873&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> <div class="journal-subject">Journal subject: Scopus - Genetics&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 24</span> | Independent citation: 19 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 22 | Number of citations in Scopus:&nbsp;23 | WoS/Scopus assigned:&nbsp;24 | Number of citations with DOI:&nbsp;22 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1138671&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 1138671</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 1138671</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2026.01.15. 13:27 Róbert Milánkovics (PTE ÁOK admin 4) </div> </div></div>