Suppression of spike-wave discharge activity and c-fos expression by 2-methyl-4-oxo-3H-quinazoline-3-acetyl piperidine (Q5) in vivo

Kovács, ZS [Kovács, Zsolt (Neurobiológia), szerző] Biológia Intézet (NymE / TTK); Puskás, L [Puskás, László (Neuromorfológia), szerző] MTA-SE Neuromorfológiai és Neuroendokrin Kutató... (MTA TKI); Nyitrai, G [Nyitrai, Gabriella, szerző] Biomolekuláris Kémiai Intézet (MTA KK); Papp, E; Császár, I; Juhász, G [Juhász, Gábor Dénes (Élettan, neurokém...), szerző]; Palkovits, M [Palkovits, Miklós (Neuroanatómia), szerző] MTA-SE Neuromorfológiai és Neuroendokrin Kutató... (MTA TKI)

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: NEUROSCIENCE LETTERS 0304-3940 1872-7972 423 (1) pp. 73-77 2007
  • SJR Scopus - Neuroscience (miscellaneous): Q2
    Antiepileptic and network inhibitory actions of Q5 (2-methyl-4-oxo-3H-quinazoline-3-acetyl piperidine) have recently been described in hippocampal slices. Here we present evidence on the in vivo antiabsence effect of Q5. All doses of Q5 tested (0.3 mg/kg, 0.9 mg/kg, 2.8 mg/kg) decreased the number, but not the duration and the frequency of absence spike-wave discharges (SWDs) in freely moving WAG/Rij rats. In vivo network inhibitory action of Q5 was monitored by following c-fos expression in different brain areas of Wistar rats. Significant depletion of c-fos expression was observed after single or repeated injections of Q5 (2.8 mg/kg and 2 x 2.8 mg/kg) in various brain areas, including hypothalamic paraventricular nucleus, medial amygdaloid nucleus, piriform cortex, sornatosensory cortex, periventricular thalamic nucleus and periaqueductal central gray. Thus, our in vivo results demonstrate that in addition to the prevention of absence seizures, Q5 effectively suppresses neuronal activation in various stress- and pain-sensitive brain areas. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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    2020-08-05 13:30