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Lovey, K
Fat necrosis after partial-breast irradiation with brachytherapy or electron irradiation versus standard whole-breast radiotherapy--4-year results of a randomized trial.
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2007
PURPOSE: To examine the incidence and clinical relevance of fat necrosis after
accelerated partial-breast irradiation (PBI) using interstitial high-dose-rate
brachytherapy (HDR-BT) in comparison with partial-breast electron irradiation
(ELE) and whole-breast irradiation (WBI). METHODS AND MATERIALS: Between 1998 and
2004, 258 early-stage breast cancer patients were randomized to receive 50 Gy WBI
(n = 130) or PBI (n = 128). The latter consisted of either 7 x 5.2 Gy HDR-BT (n =
88) or 50 Gy ELE (n = 40). The incidence of fat necrosis, its impact on cosmetic
outcome, accompanying radiologic features, and clinical symptoms were evaluated.
RESULTS: The 4-year actuarial rate of fat necrosis was 31.1% for all patients,
and 31.9%, 36.5%, and 17.7% after WBI, HDR-BT and ELE, respectively
(p(WBI/HDR-BT) = 0.26; p(WBI/ELE) = 0.11; p(ELE/HDR-BT) = 0.025). The respective
rate of asymptomatic fat necrosis was 20.2%, 25.3%, and 10% of patients. The
incidence of symptomatic fat necrosis was not significantly different after WBI
(8.5%), HDR-BT (11.4%), and ELE (7.5%). Symptomatic fat necrosis was
significantly associated with a worse cosmetic outcome, whereas asymptomatic fat
necrosis was not. Fat necrosis was detectable with mammography and/or ultrasound
in each case. Additional imaging examinations were required in 21% of cases and
aspiration cytology in 42%. CONCLUSIONS: Asymptomatic fat necrosis is a common
adverse event of breast-conserving therapy, having no significant clinical
relevance in the majority of the cases. The incidence of both symptomatic and
asymptomatic fat necrosis is similar after conventional WBI and accelerated
partial-breast HDR-BT.
2008
(Kásler Miklós (Klinikai onkológia); 2011.09.12. 13:19:12)
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Lovey, K ✉ </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10003193"> <a href="/gui2/?type=authors&mode=browse&sel=10003193" target="_blank">Fodor, J</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10044386"> <a href="/gui2/?type=authors&mode=browse&sel=10044386" target="_blank">Major, T</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Szabo, E </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001187"> <a href="/gui2/?type=authors&mode=browse&sel=10001187" target="_blank">Orosz, Z</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Sulyok, Z </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10047664"> <a href="/gui2/?type=authors&mode=browse&sel=10047664" target="_blank">Janvary, L</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10016868"> <a href="/gui2/?type=authors&mode=browse&sel=10016868" target="_blank">Frohlich, G</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10024576"> <a href="/gui2/?type=authors&mode=browse&sel=10024576" target="_blank">Kasler, M</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10013383"> <a href="/gui2/?type=authors&mode=browse&sel=10013383" target="_blank">Polgar, C</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1118079" mtid="1118079" target="_blank">Fat necrosis after partial-breast irradiation with brachytherapy or electron irradiation versus standard whole-breast radiotherapy--4-year results of a randomized trial.</a></div> <div class="pub-info"> <span class="journal-title">INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS</span> <span class="journal-volume">69</span> : <span class="journal-issue">3</span> <span class="page"> pp. 724-731. , 8 p. </span> <span class="year">(2007)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.ijrobp.2007.03.055" target="_blank" href="https://doi.org/10.1016/j.ijrobp.2007.03.055"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000249943000011" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000249943000011"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34548695438" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-34548695438"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="17524571" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17524571&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="http://www.sciencedirect.com/science/article/pii/S0360301607006499" target="_blank" href="http://www.sciencedirect.com/science/article/pii/S0360301607006499"> Teljes dokumentum </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="12633215704252640009" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=12633215704252640009"> Google scholar </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="CWvd1r8yUq8J" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=CWvd1r8yUq8J"> Google scholar hash </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:1118079 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 109</span> | Független: 95 | Függő: 14 | Nem jelölt: 0 | WoS jelölt: 81 | Scopus jelölt: 95 | WoS/Scopus jelölt: 96 | DOI jelölt: 94 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
<div class="authors">
<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" >Lovey K ✉
</span>
;
<span class="author-name" mtid="10003193"><a
href="/gui2/?type=authors&mode=browse&sel=10003193" target="_blank">Fodor J
(<span class="authorship-author-name">Fodor János</span>
<span class="authorAux-mtmt"> Orvosi tudomány</span>)
</a>
</span>
<span class="author-affil">Országos Onkológiai Intézet</span>
;
<span class="author-name" mtid="10044386"><a
href="/gui2/?type=authors&mode=browse&sel=10044386" target="_blank">Major T
(<span class="authorship-author-name">Major Tibor</span>
<span class="authorAux-mtmt"> klinikai sugárfizika</span>)
</a>
</span>
<span class="author-affil">Országos Onkológiai Intézet</span>
;
<span class="author-name" >Szabo E
</span>
;
<span class="author-name" mtid="10001187"><a
href="/gui2/?type=authors&mode=browse&sel=10001187" target="_blank">Orosz Z
(<span class="authorship-author-name">Orosz Zsolt</span>
<span class="authorAux-mtmt"> Pathológia</span>)
</a>
</span>
<span class="author-affil">Országos Onkológiai Intézet</span>
;
<span class="author-name" >Sulyok Z
</span>
;
<span class="author-name" mtid="10047664"><a
href="/gui2/?type=authors&mode=browse&sel=10047664" target="_blank">Janvary L
(<span class="authorship-author-name">Jánváry Zsolt Levente</span>
<span class="authorAux-mtmt"> Sugárterápiás onkológia</span>)
</a>
</span>
;
<span class="author-name" mtid="10016868"><a
href="/gui2/?type=authors&mode=browse&sel=10016868" target="_blank">Frohlich G
(<span class="authorship-author-name">Fröhlich Georgina</span>
<span class="authorAux-mtmt"> Sugárfizika</span>)
</a>
</span>
<span class="author-affil">Országos Onkológiai Intézet</span>
;
<span class="author-name" mtid="10024576"><a
href="/gui2/?type=authors&mode=browse&sel=10024576" target="_blank">Kasler M
(<span class="authorship-author-name">Kásler Miklós</span>
<span class="authorAux-mtmt"> Klinikai onkológia</span>)
</a>
</span>
<span class="author-affil">Országos Onkológiai Intézet</span>
;
<span class="author-name" mtid="10013383"><a
href="/gui2/?type=authors&mode=browse&sel=10013383" target="_blank">Polgar C
(<span class="authorship-author-name">Polgár Csaba</span>
<span class="authorAux-mtmt"> Sugárterápia, klinikai onkológia</span>)
</a>
</span>
<span class="author-affil">Országos Onkológiai Intézet</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;1118079" target="_blank">Fat necrosis after partial-breast irradiation with brachytherapy or electron irradiation versus standard whole-breast radiotherapy--4-year results of a randomized trial.</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0360-3016">0360-3016</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1879-355X">1879-355X</a>)</span>:
<span class="journal-volume">69</span> <span class="journal-issue">3</span>
<span class="page">
pp 724-731
</span> <span class="year">(2007)</span>
</div>
<div class="pub-footer">
<span class="language" xmlns="http://www.w3.org/1999/html">Nyelv:
Angol
| </span>
<span class="identifiers">
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="10.1016/j.ijrobp.2007.03.055" target="_blank" href="https://doi.org/10.1016/j.ijrobp.2007.03.055">
DOI
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="000249943000011" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000249943000011">
WoS
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<a style="color:blue" title="34548695438" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-34548695438">
Scopus
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<span class="id identifier oa_none" title="none">
<a style="color:blue" title="17524571" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17524571&dopt=Abstract">
PubMed
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:black" title="http://www.sciencedirect.com/science/article/pii/S0360301607006499" target="_blank" href="http://www.sciencedirect.com/science/article/pii/S0360301607006499">
Teljes dokumentum
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:black" title="12633215704252640009" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=12633215704252640009">
Google scholar
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<a style="color:black" title="CWvd1r8yUq8J" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=CWvd1r8yUq8J">
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<div class="publication-citation" style="margin-left: 0.5cm;">
<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 109</span>
| Független: 95
| Függő: 14
| Nem jelölt: 0
| WoS jelölt: 81
| Scopus jelölt: 95
| WoS/Scopus jelölt: 96
| DOI jelölt: 94
</div>
<div class="publication-citation">
<a target="_blank" href="/api/publication?cond=citations.related;eq;1118079&sort=publishedYear,desc&sort=title">
Idézett közlemények száma: 3
</a>
</div>
<div class="mtid"><span class="long-pub-mtid">Közlemény: 1118079</span>
| <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott
</span>
<span class="oldId">Régi azonosító: 1118079</span> |
Forrás Idéző
| <span class="type-subtype">Folyóiratcikk
( Szakcikk
)
</span>
| <span class="pub-category">Tudományos</span>
| <span class="publication-sourceOfData">MEDLINE</span>
</div>
<div class="lastModified">Utolsó módosítás: 2023.01.20. 12:12 Pécsi Éva (MTMT Közp 3, admin)
</div>
<div class="lockedBy">Ideiglenesen zárolva 2024.02.12. 15:11 Pécsi Éva (MTMT Közp 3, admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megjegyzés-20317363
Cited By (since 1996): 1</pre>
</div></div>