https://m2.mtmt.hu/ eng 2026-10-22 23:08 JournalArticle 110035 APPROVED true Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Research Institute for Solid State Physics and Optics, Hungarian Academy of Sciences, Budapest, Hungary Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Cited By :24 Export Date: 18 March 2024 CODEN: EJONE Correspondence Address: Sylvester Vizi, E.; Department of Pharmacology and Pharmacotherapy, , Budapest, Hungary; email: esvizi@koki.hu Chemicals/CAS: calcium ion, 14127-61-8; alpha-bungarotoxin receptor; Receptors, Nicotinic 0 2017-02-22T09:05:52.000+0000 false 110035 2026-10-12T20:02:25.625+0000 2023-07-28T12:20:55.326+0000 2010-06-13T19:05:16.000+0000 true 10003154 Wolf György /api/admin/10003154 Admin true 10003154 2026-01-12T09:27:41.367+0000 2026-01-12T09:27:41.367+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Rozsa, B Dendritic nicotinic receptors modulate backpropagating action potentials and long-term plasticity of interneurons true true /api/journal/1510 REVIEWED true false 1510 false 1510 true 0953-816X 1460-9568 Journal FOREIGN 27 2 364 377 364 14 2008 Stratum radiatum interneurons, unlike pyramidal cells, are rich in nicotinic acetylcholine receptors (nAChRs); however, the role of these receptors in plasticity has remained elusive. As opposed to previous physiological studies, we found that functional alpha7-subunit-containing nAChRs (alpha7-nAChRs) are abundant on interneuron dendrites of rats. Moreover, dendritic Ca2+ transients induced by activation of alpha7-nAChRs increase as a function of distance from soma. The activation of these extrasynaptic alpha7-nAChRs by cholinergic agonists either facilitated or depressed backpropagating action potentials, depending on the timing of alpha7-nAChR activation. We have previously shown that dendritic alpha7-nAChRs are involved in the regulation of synaptic transmission, suggesting that alpha7-nAChRs may play an important role in the regulation of the spike timing-dependent plasticity. Here we provide evidence that long-term potentiation is indeed boosted by stimulation of dendritic alpha7-nAChRs. Our results suggest a new mechanism for a cholinergic switch in memory encoding and retrieval. 2010 true true true false true false NONE 2026-10-12 false 30 0 28 22 9 28 26 26 25 27 27 21 21 24 6 0 30 24 28 22 0 13 13 Folyóiratcikk Journal Article 24 26 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2008 0 3 3 3 3 2009 0 3 3 3 3 2010 0 4 2 4 2 2011 0 2 1 2 1 2012 0 6 5 6 5 2013 0 1 1 1 1 2014 0 5 4 5 4 2015 0 0 0 0 0 2016 0 3 2 3 2 2017 0 1 1 1 1 2018 0 0 0 0 0 2019 0 0 0 0 0 2020 0 0 0 0 0 2021 0 0 0 0 0 2022 0 1 1 1 1 2023 0 0 0 0 0 2024 0 1 1 1 1 Q1 false false false false 2010-09-28T10:18:06.000+0000 2013-02-23T19:18:00.000+0000 Farmakológiai Kutatócsoport (KOKI / GYO); Két-foton Képalkotó Központ (KOKI / GYO); MTA Kísérleti Orvostudományi Kutatóintézet 5 45 3 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 91903 /api/authorship/91903 1 0.2 true false Author 10012926 /api/author/10012926 Rózsa J. Balázs true 10012926 true Rozsa B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20227 true PersonAuthorship 91904 /api/authorship/91904 2 0.2 false false Author 191 /api/author/191 Katona Gergely true 191 true Katona G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20226 true PersonAuthorship 91905 /api/authorship/91905 3 0.2 false false Author 227 /api/author/227 Kaszás Attila true 227 true Kaszas A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20225 true PersonAuthorship 109457855 /api/authorship/109457855 4 0.0 false false Author 195 /api/author/195 Szipőcs Róbert true 195 true Szipőcs Róbert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 91907 /api/authorship/91907 5 0.2 false true true Author 10000023 /api/author/10000023 Vizi E. Szilveszter true 10000023 true Vizi ES true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20223 true PublicationIdentifier 37543 /api/publicationidentifier/37543 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1111/j.1460-9568.2007.05999.x https://doi.org/10.1111/j.1460-9568.2007.05999.x false 11691 true PublicationIdentifier 37541 /api/publicationidentifier/37541 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000252495700011 https://www.webofscience.com/wos/woscc/full-record/000252495700011 false 11692 true PublicationIdentifier 37542 /api/publicationidentifier/37542 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 38349172660 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-38349172660 false 470171 true PublicationIdentifier 37544 /api/publicationidentifier/37544 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 18215234 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18215234&dopt=Abstract false 11693 true Classification 12125 /api/classification/12125 true true SjrRating 5857794 /api/sjrrating/5857794 16 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true Q1 DIRECT true 5857794 true /api/publication/110035 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10012926"><a href="/gui2/?type=authors&mode=browse&sel=10012926" target="_blank">Rozsa B (<span class="authorship-author-name">Rózsa J. Balázs</span> <span class="authorAux-mtmt"> Idegtudomány, fizika</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Two-photon Imaging Center</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="191"><a href="/gui2/?type=authors&mode=browse&sel=191" target="_blank">Katona G (<span class="authorship-author-name">Katona Gergely</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="227"><a href="/gui2/?type=authors&mode=browse&sel=227" target="_blank">Kaszas A (<span class="authorship-author-name">Kaszás Attila</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Drug Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="195"><a href="/gui2/?type=authors&mode=browse&sel=195" target="_blank">Szipőcs Róbert (<span class="authorship-author-name">Szipőcs Róbert</span> <span class="authorAux-mtmt"> fizika, optika, lézerfizika, mikroszkópia, kisé...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000023"><a href="/gui2/?type=authors&mode=browse&sel=10000023" target="_blank">Vizi ES ✉ (<span class="authorship-author-name">Vizi E. Szilveszter</span> <span class="authorAux-mtmt"> Neurofarmakológia, neurokémia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Drug Research</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;110035" target="_blank">Dendritic nicotinic receptors modulate backpropagating action potentials and long-term plasticity of interneurons</a></div> <div> <span class="journal-title">EUROPEAN JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0953-816X">0953-816X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1460-9568">1460-9568</a>)</span>: <span class="journal-volume">27</span> <span class="journal-issue">2</span> <span class="page"> pp 364-377 </span> <span class="year">(2008)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/j.1460-9568.2007.05999.x" target="_blank" href="https://doi.org/10.1111/j.1460-9568.2007.05999.x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000252495700011" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000252495700011"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38349172660" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-38349172660"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="18215234" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18215234&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 30</span> | Independent citation: 24 | Self citation: 6 | Unknown citation: 0 | Number of citations in WoS: 26 | Number of citations in Scopus:&nbsp;25 | WoS/Scopus assigned:&nbsp;27 | Number of citations with DOI:&nbsp;26 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;110035&sort=publishedYear,desc&sort=title"> Number of cited publications: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 110035</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 110035</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2023.07.28. 14:20 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Research Institute for Solid State Physics and Optics, Hungarian Academy of Sciences, Budapest, Hungary Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Cited By :24 Export Dat...</pre> </div></div>