https://m2.mtmt.hu/ eng 2026-10-23 06:16 JournalArticle 109959 APPROVED true Cited By :390 Export Date: 31 March 2021 CODEN: NAMEF Correspondence Address: Katona, I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: katona@koki.hu Chemicals/CAS: anandamide, 94421-68-8; rimonabant, 158681-13-1, 168273-06-1; Endocannabinoids Funding details: DA009158 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute on Drug Abuse, NIDA, P01DA009158 Funding details: Egészségügyi Tudományos Tanács, ETT, 561/2006 Funding details: European Commission, EC, LSHM-CT-2004-005166 Funding text 1: This work was supported by the Howard Hughes Medical Institute, the Egészségügyi Tudományos Tanács 561/2006, the János Bolyai scholarship (I.K.) and the US National Institutes of Health DA009158 and European Union Contract LSHM-CT-2004-005166. We are very grateful to N. Hájos, K. Mackie, D. Piomelli and M. Watanabe for their long-term collaborative support of our work on the endocannabinoid system and to I. Mody and N. Hájos for their comments on the manuscript. We are also indebted to B. Baksa, G. Nyiri and B. Dudok for their help with the preparation of figures. Cited By :390 Export Date: 1 April 2021 CODEN: NAMEF Correspondence Address: Katona, I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: katona@koki.hu Chemicals/CAS: anandamide, 94421-68-8; rimonabant, 158681-13-1, 168273-06-1; Endocannabinoids Funding details: DA009158 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute on Drug Abuse, NIDA, P01DA009158 Funding details: Egészségügyi Tudományos Tanács, ETT, 561/2006 Funding details: European Commission, EC, LSHM-CT-2004-005166 Funding text 1: This work was supported by the Howard Hughes Medical Institute, the Egészségügyi Tudományos Tanács 561/2006, the János Bolyai scholarship (I.K.) and the US National Institutes of Health DA009158 and European Union Contract LSHM-CT-2004-005166. We are very grateful to N. Hájos, K. Mackie, D. Piomelli and M. Watanabe for their long-term collaborative support of our work on the endocannabinoid system and to I. Mody and N. Hájos for their comments on the manuscript. We are also indebted to B. Baksa, G. Nyiri and B. Dudok for their help with the preparation of figures. Cited By :392 Export Date: 17 May 2021 CODEN: NAMEF Correspondence Address: Katona, I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: katona@koki.hu Chemicals/CAS: anandamide, 94421-68-8; rimonabant, 158681-13-1, 168273-06-1; Endocannabinoids Funding details: DA009158 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute on Drug Abuse, NIDA, P01DA009158 Funding details: Egészségügyi Tudományos Tanács, ETT, 561/2006 Funding details: European Commission, EC, LSHM-CT-2004-005166 Funding text 1: This work was supported by the Howard Hughes Medical Institute, the Egészségügyi Tudományos Tanács 561/2006, the János Bolyai scholarship (I.K.) and the US National Institutes of Health DA009158 and European Union Contract LSHM-CT-2004-005166. We are very grateful to N. Hájos, K. Mackie, D. Piomelli and M. Watanabe for their long-term collaborative support of our work on the endocannabinoid system and to I. Mody and N. Hájos for their comments on the manuscript. We are also indebted to B. Baksa, G. Nyiri and B. Dudok for their help with the preparation of figures. Cited By :399 Export Date: 12 August 2021 CODEN: NAMEF Correspondence Address: Katona, I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: katona@koki.hu Chemicals/CAS: anandamide, 94421-68-8; rimonabant, 158681-13-1, 168273-06-1; Endocannabinoids Funding details: DA009158 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute on Drug Abuse, NIDA, P01DA009158 Funding details: Egészségügyi Tudományos Tanács, ETT, 561/2006 Funding details: European Commission, EC, LSHM-CT-2004-005166 Funding text 1: This work was supported by the Howard Hughes Medical Institute, the Egészségügyi Tudományos Tanács 561/2006, the János Bolyai scholarship (I.K.) and the US National Institutes of Health DA009158 and European Union Contract LSHM-CT-2004-005166. We are very grateful to N. Hájos, K. Mackie, D. Piomelli and M. Watanabe for their long-term collaborative support of our work on the endocannabinoid system and to I. Mody and N. Hájos for their comments on the manuscript. We are also indebted to B. Baksa, G. Nyiri and B. Dudok for their help with the preparation of figures. Cited By :400 Export Date: 7 September 2021 CODEN: NAMEF Correspondence Address: Katona, I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: katona@koki.hu Chemicals/CAS: anandamide, 94421-68-8; rimonabant, 158681-13-1, 168273-06-1; Endocannabinoids Funding details: DA009158 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute on Drug Abuse, NIDA, P01DA009158 Funding details: Egészségügyi Tudományos Tanács, ETT, 561/2006 Funding details: European Commission, EC, LSHM-CT-2004-005166 Funding text 1: This work was supported by the Howard Hughes Medical Institute, the Egészségügyi Tudományos Tanács 561/2006, the János Bolyai scholarship (I.K.) and the US National Institutes of Health DA009158 and European Union Contract LSHM-CT-2004-005166. We are very grateful to N. Hájos, K. Mackie, D. Piomelli and M. Watanabe for their long-term collaborative support of our work on the endocannabinoid system and to I. Mody and N. Hájos for their comments on the manuscript. We are also indebted to B. Baksa, G. Nyiri and B. Dudok for their help with the preparation of figures. Cited By :401 Export Date: 9 September 2021 CODEN: NAMEF Correspondence Address: Katona, I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: katona@koki.hu Chemicals/CAS: anandamide, 94421-68-8; rimonabant, 158681-13-1, 168273-06-1; Endocannabinoids Funding details: DA009158 Funding details: Howard Hughes Medical Institute, HHMI Funding details: National Institute on Drug Abuse, NIDA, P01DA009158 Funding details: Egészségügyi Tudományos Tanács, ETT, 561/2006 Funding details: European Commission, EC, LSHM-CT-2004-005166 Funding text 1: This work was supported by the Howard Hughes Medical Institute, the Egészségügyi Tudományos Tanács 561/2006, the János Bolyai scholarship (I.K.) and the US National Institutes of Health DA009158 and European Union Contract LSHM-CT-2004-005166. We are very grateful to N. Hájos, K. Mackie, D. Piomelli and M. Watanabe for their long-term collaborative support of our work on the endocannabinoid system and to I. Mody and N. Hájos for their comments on the manuscript. We are also indebted to B. Baksa, G. Nyiri and B. Dudok for their help with the preparation of figures. 0 2017-02-22T09:05:51.000+0000 false 109959 2026-10-16T07:32:58.982+0000 2022-07-15T10:10:40.012+0000 2010-06-13T19:04:15.000+0000 true 10003154 Wolf György /api/admin/10003154 Admin true 10003154 2025-04-16T12:33:55.689+0000 2025-04-16T12:33:55.689+0000 2013-02-13T14:52:32.000+0000 true 10023792 Suchanek-Lukács Margit /api/admin/10023792 Admin true 10023792 2019-09-04T20:14:49.595+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Katona, I Endocannabinoid signaling as a synaptic circuit breaker in neurological disease true true /api/journal/9317 REVIEWED true false 9317 false 9317 true 1078-8956 1546-170X Journal FOREIGN 14 9 923 930 923 8 2008 Cannabis sativa is one of the oldest herbal plants in the history of medicine. It was used in various therapeutic applications from pain to epilepsy, but its psychotropic effect has reduced its usage in recent medical practice. However, renewed interest has been fueled by major discoveries revealing that cannabis-derived compounds act through a signaling pathway in the human body. Here we review recent advances showing that endocannabinoid signaling is a key regulator of synaptic communication throughout the central nervous system. Its underlying molecular architecture is highly conserved in synapses from the spinal cord to the neocortex, and as a negative feed-back signal, it provides protection against excess presynaptic activity. The endocannabinoid signaling machinery operates on demand in a synapse-specific manner; therefore, its modulation offers new therapeutic opportunities for the selective control of deleterious neuronal activity in several neurological disorders. true true 2010 true true true false true false NONE 2026-10-16 false 524 0 524 509 41 521 516 495 518 521 521 506 506 509 15 0 524 509 524 509 0 14 14 Folyóiratcikk Journal Article 24 507 Könyvrészlet Chapter in Book 25 17 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2008 0 2 1 2 1 2009 0 29 28 29 28 2010 0 32 32 32 32 2011 0 35 32 35 32 2012 0 52 48 52 48 2013 0 31 30 31 30 2014 0 39 38 39 38 2015 0 39 38 39 38 2016 0 30 30 30 30 2017 0 21 21 21 21 2018 0 34 34 34 34 2019 0 20 20 20 20 2020 0 26 25 26 25 2021 0 26 26 26 26 2022 0 28 28 28 28 2023 0 26 25 26 25 2024 0 19 19 19 19 2025 0 29 28 29 28 2026 0 6 6 6 6 D1 true 10011502,10000275 false false false 2013-02-13T14:52:32.000+0000 2013-02-13T14:45:51.000+0000 Agykéreg Kutatócsoport (KOKI / CHO); MTA Kísérleti Orvostudományi Kutatóintézet 2 20 2 2 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 91582 /api/authorship/91582 1 0.5 true false Author 10011502 /api/author/10011502 Katona István true 10011502 true Katona I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19542 true PersonAuthorship 91583 /api/authorship/91583 2 0.5 false true Author 10000275 /api/author/10000275 Freund Tamás true 10000275 true Freund TF true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19541 true PublicationIdentifier 37334 /api/publicationidentifier/37334 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1038/nm.f.1869 https://doi.org/10.1038/nm.f.1869 false 11586 true PublicationIdentifier 37332 /api/publicationidentifier/37332 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000258988600024 https://www.webofscience.com/wos/woscc/full-record/000258988600024 false 11587 true PublicationIdentifier 37333 /api/publicationidentifier/37333 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 51349141952 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-51349141952 false 1401014 true PublicationIdentifier 37335 /api/publicationidentifier/37335 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 18776886 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18776886&dopt=Abstract false 11588 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12548 /api/classification/12548 true true Classification 12215 /api/classification/12215 true true SjrRating 5850740 /api/sjrrating/5850740 11 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true 5850740 true /api/publication/109959 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10011502"><a href="/gui2/?type=authors&mode=browse&sel=10011502" target="_blank">Katona I (<span class="authorship-author-name">Katona István</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000275"><a href="/gui2/?type=authors&mode=browse&sel=10000275" target="_blank">Freund TF (<span class="authorship-author-name">Freund Tamás</span> <span class="authorAux-mtmt"> Neurobiológia, idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cerebral Cortex Research</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;109959" target="_blank">Endocannabinoid signaling as a synaptic circuit breaker in neurological disease</a></div> <div> <span class="journal-title">NATURE MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1078-8956">1078-8956</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1546-170X">1546-170X</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">9</span> <span class="page"> pp 923-930 </span> <span class="year">(2008)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/nm.f.1869" target="_blank" href="https://doi.org/10.1038/nm.f.1869"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000258988600024" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000258988600024"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="51349141952" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-51349141952"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="18776886" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18776886&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 524</span> | Independent citation: 509 | Self citation: 15 | Unknown citation: 0 | Number of citations in WoS: 495 | Number of citations in Scopus:&nbsp;518 | WoS/Scopus assigned:&nbsp;521 | Number of citations with DOI:&nbsp;516 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;109959&sort=publishedYear,desc&sort=title"> Number of cited publications: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 109959</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 109959</span> | Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2022.07.15. 12:10 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :390 Export Date: 31 March 2021 CODEN: NAMEF Correspondence Address: Katona, I.; Institute of Experimental Medicine, Szigony utca 43, H-1083 Budapest, Hungary; email: katona@koki.hu Chemicals/CAS: anandamide, 94421-68-8; rimonabant, 158681-13-1, 168273-06-1; Endocannabinoids ...</pre> </div></div>