https://m2.mtmt.hu/ eng 2026-10-24 10:49 JournalArticle 109956 APPROVED true Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083, Hungary Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, Netherlands Division of Endocrinology and Metabolism, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, United States Division of Endocrinology, Diabetes and Metabolism, University of Miami, Miller School of Medicine, Miami, FL 33136, United States Division of Endocrinology, Diabetes and Metabolism, Dominion Towers, 1400 NW 10th Avenue, Miami, FL 33136, United States Cited By :682 Export Date: 28 February 2025 CODEN: ERVID Correspondence Address: Bianco, A. C.; Division of Endocrinology, Diabetes and Metabolism, 1400 NW 10th Avenue, Miami, FL 33136, United States; email: abianco@deiodinase.org Chemicals/CAS: alanine, 56-41-7, 6898-94-8; iodide peroxidase, 9031-28-1; iodothyronine, 29354-16-3; liothyronine, 6138-47-2, 6893-02-3; protirelin, 24305-27-9; selenocysteine, 3614-08-2; thioredoxin, 52500-60-4; threonine, 36676-50-3, 72-19-5; thyrotropin, 9002-71-5; thyroxine deiodinase, 70712-46-8; Iodide Peroxidase, EC 1.11.1.8; Thyroxine, 7488-70-2; Triiodothyronine, 6893-02-3 Funding details: National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK, F32DK078476 0 2017-02-22T09:05:51.000+0000 false 109956 2026-10-15T20:30:38.504+0000 2025-02-27T13:40:34.195+0000 2010-06-13T19:04:12.000+0000 true 10003154 Wolf György /api/admin/10003154 Admin true 10003154 2026-05-19T11:35:43.673+0000 2026-05-19T11:35:43.673+0000 2018-12-10T09:13:50.419+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 2018-12-10T09:13:57.596+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Gereben, B Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling true true /api/journal/1408 REVIEWED true false 1408 false 1408 true 0163-769X 1945-7189 Journal FOREIGN 29 7 898 938 898 41 2008 The iodothyronine deiodinases initiate or terminate thyroid hormone action, and therefore are critical for the biological effects mediated by thyroid hormone. Over the years research has focused on their role in preserving serum levels of the biologically active molecule triiodothyronine (T3) during iodine deficiency. More recently, a fascinating new role of these enzymes has been unveiled. The activating deiodinase (D2) and the inactivating deiodinase (D3) can locally increase or decrease thyroid hormone signaling in a tissue- and temporal-specific fashion, independently of changes in thyroid hormone serum concentrations. This mechanism is particularly relevant as deiodinase expression can be modulated by a wide variety of endogenous signaling molecules such as sonic hedgehog, NF-kappaB, growth factors, bile acids, HIF-1alpha, as well as a growing number of xenobiotic substances. In light of these findings, it seems clear that deiodinases play a much broader role than once thought, with great ramifications for the control of thyroid hormone signaling during vertebrate development and metamorphosis, as well as injury response, tissue repair, hypothalamic function, and energy homeostasis in adults. 2010 true true true false true false NONE 2026-10-15 false 755 0 755 652 34 745 737 678 730 754 754 651 651 652 103 0 755 652 755 652 0 34 34 Folyóiratcikk Journal Article 24 694 Könyvrészlet Chapter in Book 25 56 Könyv Book 23 5 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 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/api/authorship/91565 2 0.125 false false Zavacki AM true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19522 true PersonAuthorship 91566 /api/authorship/91566 3 0.125 false false Ribich S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19521 true PersonAuthorship 91567 /api/authorship/91567 4 0.125 false false Kim BW true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19520 true PersonAuthorship 91568 /api/authorship/91568 5 0.125 false false Huang SA true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19519 true PersonAuthorship 91569 /api/authorship/91569 6 0.125 false false Simonides WS true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19518 true PersonAuthorship 91570 /api/authorship/91570 7 0.125 false false Author 10013473 /api/author/10013473 Zeöld Anikó true 10013473 true Zeold A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true 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/api/classificationexternal/1310 true 1310 true D1 DIRECT true 5831118 true /api/publication/109956 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10011473"><a href="/gui2/?type=authors&mode=browse&sel=10011473" target="_blank">Gereben B (<span class="authorship-author-name">Gereben Balázs</span> <span class="authorAux-mtmt"> Pajzsmirigy endokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zavacki AM </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ribich S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kim BW </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Huang SA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Simonides WS </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013473"><a href="/gui2/?type=authors&mode=browse&sel=10013473" target="_blank">Zeold A (<span class="authorship-author-name">Zeöld Anikó</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bianco AC </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;109956" target="_blank">Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling</a></div> <div> <span class="journal-title">ENDOCRINE REVIEWS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0163-769X">0163-769X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1945-7189">1945-7189</a>)</span>: <span class="journal-volume">29</span> <span class="journal-issue">7</span> <span class="page"> pp 898-938 </span> <span class="year">(2008)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1210/er.2008-0019" target="_blank" href="https://doi.org/10.1210/er.2008-0019"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000261450300004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000261450300004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="57349119069" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-57349119069"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="18815314" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18815314&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 755</span> | Independent citation: 652 | Self citation: 103 | Unknown citation: 0 | Number of citations in WoS: 678 | Number of citations in Scopus:&nbsp;730 | WoS/Scopus assigned:&nbsp;754 | Number of citations with DOI:&nbsp;737 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;109956&sort=publishedYear,desc&sort=title"> Number of cited publications: 34 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 109956</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 109956</span> | Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.02.27. 14:40 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1083, Hungary Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States Laboratory for Physiology, Institute for Cardiovascular Research, VU Universit...</pre> </div></div>