https://m2.mtmt.hu/ eng 2026-10-23 22:01 JournalArticle 109944 APPROVED true Cited By :255 Export Date: 6 April 2023 CODEN: JNRSD Correspondence Address: Lorincz, A.; Laboratory of Cellular Neurophysiology, Szigony Street 43, 1083 Budapest, Hungary; email: lorincz@koki.hu Chemicals/CAS: Ion Channels; Kv1.1 Potassium Channel, 147173-20-4; Kv1.2 Potassium Channel; Nav1.6 protein, rat; Nerve Tissue Proteins; Sodium Channels; sodium channel, voltage-gated, type I, alpha protein 0 2017-08-21T11:15:27.000+0000 false 109944 2026-10-15T20:33:08.575+0000 2023-03-21T10:34:07.451+0000 2010-06-13T19:04:01.000+0000 true 10003154 Wolf György /api/admin/10003154 Admin true 10003154 2025-03-17T08:33:31.616+0000 2025-03-17T08:33:31.616+0000 2010-08-30T15:20:15.000+0000 true 10003154 Wolf György /api/admin/10003154 Admin true 10003154 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Lorincz, A Cell-type-dependent molecular composition of the axon initial segment true true /api/journal/2707 REVIEWED true false 2707 false 2707 true 0270-6474 1529-2401 Journal FOREIGN 28 53 14329 14340 14329 12 2008 The exact site of initiation and shape of action potentials vary among different neuronal types. The reason for this variability is largely unknown, but the subunit composition, density and distribution of voltage-gated sodium (Nav) and potassium (Kv) channels within the axon initial segment (AIS) are likely to play a key role. Here, we asked how heterogeneous are the density and distribution of Nav and Kv channels within the AISs of a variety of excitatory and inhibitory neurons. Most of the studied cell types expressed a high density of Nav1.6, Kv1.1, and Kv1.2 subunits in their AIS, but the Nav1.1 subunit could only be detected in GABAergic interneurons. A proximo-distal gradient in the density of these subunits was observed within the AIS of certain nerve cells but not in others. For example, a gradual increase of the Nav1.6 subunit was observed in cortical layer 2/3 and hippocampal CA1 pyramidal cell (PC) AISs, whereas its density was rather uniform in layer 5 PC AISs. The Nav1.1 subunit was distributed evenly along the AIS of short-axon cells of the main olfactory bulb but was restricted to the proximal part of the AIS in cortical and cerebellar interneurons. Our results reveal a cell type-dependent expression of sodium and potassium channel subunits with varying densities along the proximo-distal axis of the AISs. This precise arrangement is likely to contribute to the diversity of firing properties observed among central neurons. true true 2010 true true true false true false NONE 2026-10-15 false true 10039736 xRadó Nikolett /api/admin/10039736 Admin true 10039736 285 0 285 279 10 282 285 281 279 285 285 279 279 279 6 0 285 279 285 279 0 10 10 Folyóiratcikk Journal Article 24 282 Könyvrészlet Chapter in Book 25 3 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2009 0 4 3 4 3 2010 0 16 15 16 15 2011 0 15 15 15 15 2012 0 21 20 21 20 2013 0 13 13 13 13 2014 0 26 25 26 25 2015 0 15 15 15 15 2016 0 17 16 17 16 2017 0 15 15 15 15 2018 0 21 21 21 21 2019 0 19 19 19 19 2020 0 21 20 21 20 2021 0 15 15 15 15 2022 0 9 9 9 9 2023 0 19 19 19 19 2024 0 6 6 6 6 2025 0 23 23 23 23 2026 0 10 10 10 10 D1 false 10000499 false false false 2010-08-30T15:20:15.000+0000 2013-02-23T19:18:00.000+0000 Celluláris Idegélettani Kutatócsoport (HRN KOKI) 2 9 1 2 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 91488 /api/authorship/91488 1 0.5 true false true Author 10012931 /api/author/10012931 Lőrincz Andrea true 10012931 true Lorincz A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19415 true PersonAuthorship 91489 /api/authorship/91489 2 0.5 false true Author 10000499 /api/author/10000499 Nusser Zoltán true 10000499 true Nusser Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 19414 true PublicationIdentifier 37276 /api/publicationidentifier/37276 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1523/JNEUROSCI.4833-08.2008 https://doi.org/10.1523/JNEUROSCI.4833-08.2008 false 616931 true PublicationIdentifier 37274 /api/publicationidentifier/37274 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000262137800001 https://www.webofscience.com/wos/woscc/full-record/000262137800001 false 616932 true PublicationIdentifier 37275 /api/publicationidentifier/37275 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 58149393984 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-58149393984 false 1622213 true PublicationIdentifier 37277 /api/publicationidentifier/37277 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 19118165 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19118165&dopt=Abstract false 11564 true Classification 12125 /api/classification/12125 true true SjrRating 5857786 /api/sjrrating/5857786 8 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true D1 DIRECT true 5857786 true /api/publication/109944 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10012931"><a href="/gui2/?type=authors&mode=browse&sel=10012931" target="_blank">Lorincz A ✉ (<span class="authorship-author-name">Lőrincz Andrea</span> <span class="authorAux-mtmt"> Neuroanatómia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Z (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;109944" target="_blank">Cell-type-dependent molecular composition of the axon initial segment</a></div> <div> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0270-6474">0270-6474</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1529-2401">1529-2401</a>)</span>: <span class="journal-volume">28</span> <span class="journal-issue">53</span> <span class="page"> pp 14329-14340 </span> <span class="year">(2008)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1523/JNEUROSCI.4833-08.2008" target="_blank" href="https://doi.org/10.1523/JNEUROSCI.4833-08.2008"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000262137800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000262137800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="58149393984" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-58149393984"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="19118165" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19118165&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 285</span> | Independent citation: 279 | Self citation: 6 | Unknown citation: 0 | Number of citations in WoS: 281 | Number of citations in Scopus:&nbsp;279 | WoS/Scopus assigned:&nbsp;285 | Number of citations with DOI:&nbsp;285 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;109944&sort=publishedYear,desc&sort=title"> Number of cited publications: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 109944</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 109944</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2023.03.21. 11:34 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :255 Export Date: 6 April 2023 CODEN: JNRSD Correspondence Address: Lorincz, A.; Laboratory of Cellular Neurophysiology, Szigony Street 43, 1083 Budapest, Hungary; email: lorincz@koki.hu Chemicals/CAS: Ion Channels; Kv1.1 Potassium Channel, 147173-20-4; Kv1.2 Potassium Channel; Nav1.6 protei...</pre> </div></div>