https://m2.mtmt.hu/ eng 2026-10-23 19:36 JournalArticle 109813 VALIDATED true Cited By :80 Export Date: 1 August 2023 CODEN: PBRRA Correspondence Address: Acsády, L.; Institute of Experimental Medicine, PO Box 67, 1450 Budapest, Hungary; email: acsady@koki.hu Funding details: Wellcome Trust, WT Funding details: Hungarian Scientific Research Fund, OTKA, OTKA T 049100 Funding text 1: This work was supported by the Wellcome Trust (A.L. is the recipient of a Wellcome Trust International Senior Fellowship), the Institut de Cerveau et de la Moelle épiniere, the Hungarian Scientific Research Fund (OTKA T 049100) and the EU Framework 6. 0 2017-02-22T09:05:47.000+0000 false 109813 2026-10-12T19:50:53.745+0000 2025-03-26T14:53:23.446+0000 2010-06-13T19:02:14.000+0000 true 10003154 Wolf György /api/admin/10003154 Admin true 10003154 2026-10-08T11:27:45.493+0000 2026-10-08T11:27:45.493+0000 2019-09-05T15:26:15.808+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10003134 /api/admin/10003134 Wolf György true 10003134 true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:42:14.442+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Acsady, L Models, structure, function: the transformation of cortical signals in the dentate gyrus true true /api/journal/3764 REVIEWED true false 3764 false 3764 true 0079-6123 1875-7855 Journal FOREIGN 163 577 599 577 23 2007 Our central question is why the hippocampal CA3 region is the only cortical area capable of forming interference-free representations of complex environmental events (episodes), given that apparently all cortical regions have recurrent excitatory circuits with modifiable synapses, the basic substrate for autoassociative memory networks. We review evidence for the radical (but classic) view that a unique transformation of incoming cortical signals by the dentate gyrus and the subsequent faithful transfer of the resulting code by the mossy fibers are absolutely critical for the appropriate association of memory items by CA3 and, in general, for hippocampal function. In particular, at the gate of the hippocampal formation, the dentate gyrus possesses a set of unusual properties, which selectively evolved for the task of code transformation between cortical afferents and the hippocampus. These evolutionarily conserved anatomical features enable the dentate gyrus to translate the noisy signal of the upstream cortical areas into the sparse and specific code of hippocampal formation, which is indispensable for the efficient storage and recall of multiple, multidimensional memory items. To achieve this goal the mossy fiber pathway maximally utilizes the opportunity to differentially regulate its postsynaptic partners. Selective innervation of CA3 pyramidal cells and interneurons by distinct terminal types creates a favorable condition to differentially regulate the short-term and long-term plasticity and the motility of various mossy terminal types. The utility of this highly dynamic system appears to be the frequency-dependent fine-tuning the excitation and inhibition evoked by the large and the small mossy terminals respectively. 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Thalamus Kutatócsoport (HRN KOKI) 2 17 2 2 0 true 10003134 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 90822 /api/authorship/90822 1 0.5 true false Author 10009548 /api/author/10009548 Acsády László true 10009548 true Acsady L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18328 true PersonAuthorship 90823 /api/authorship/90823 2 0.5 false true Author 10011500 /api/author/10011500 Káli Szabolcs true 10011500 true Kali S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 18327 true PublicationIdentifier 36897 /api/publicationidentifier/36897 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1016/S0079-6123(07)63031-3 https://doi.org/10.1016/S0079-6123%2807%2963031-3 false 11404 true PublicationIdentifier 36895 /api/publicationidentifier/36895 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000251961200032 https://www.webofscience.com/wos/woscc/full-record/000251961200032 false 11405 true PublicationIdentifier 36896 /api/publicationidentifier/36896 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 34548266605 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-34548266605 false 1234736 true PublicationIdentifier 36898 /api/publicationidentifier/36898 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 17765739 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17765739&dopt=Abstract false 11406 true Classification 12125 /api/classification/12125 true true Keyword 12 /api/keyword/12 true 12 true Keyword 3426 /api/keyword/3426 true 3426 true Keyword 3696 /api/keyword/3696 true 3696 true Keyword 13908 /api/keyword/13908 true 13908 true Keyword 21074 /api/keyword/21074 true 21074 true Keyword 21075 /api/keyword/21075 true 21075 true SjrRating 5898862 /api/sjrrating/5898862 26 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true Q1 DIRECT true 5898862 true /api/publication/109813 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10009548"><a href="/gui2/?type=authors&mode=browse&sel=10009548" target="_blank">Acsady L (<span class="authorship-author-name">Acsády László</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Thalamus Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011500"><a href="/gui2/?type=authors&mode=browse&sel=10011500" target="_blank">Kali S (<span class="authorship-author-name">Káli Szabolcs</span> <span class="authorAux-mtmt"> Elméleti neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cerebral Cortex Research</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;109813" target="_blank">Models, structure, function: the transformation of cortical signals in the dentate gyrus</a></div> <div> <span class="journal-title">PROGRESS IN BRAIN RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0079-6123">0079-6123</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1875-7855">1875-7855</a>)</span>: <span class="journal-volume">163</span> <span class="page"> pp 577-599 </span> <span class="year">(2007)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/S0079-6123(07)63031-3" target="_blank" href="https://doi.org/10.1016/S0079-6123%2807%2963031-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000251961200032" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000251961200032"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34548266605" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-34548266605"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="17765739" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17765739&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 88</span> | Independent citation: 88 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 86 | Number of citations in Scopus:&nbsp;87 | WoS/Scopus assigned:&nbsp;88 | Number of citations with DOI:&nbsp;88 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;109813&sort=publishedYear,desc&sort=title"> Number of cited publications: 25 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 109813</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 109813</span> | Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="notDuplums"><a target="_blank" href="/api/publication/109813/notduplums">10 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2025.03.26. 15:53 Gusztáv Ladányi (MTMT API user, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:42 György Wolf (MTMT Központi admin) Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :80 Export Date: 1 August 2023 CODEN: PBRRA Correspondence Address: Acsády, L.; Institute of Experimental Medicine, PO Box 67, 1450 Budapest, Hungary; email: acsady@koki.hu Funding details: Wellcome Trust, WT Funding details: Hungarian Scientific Research Fund, OTKA, ...</pre> </div></div>