https://m2.mtmt.hu/ eng 2026-10-23 17:11 JournalArticle 109812 APPROVED true 0 2017-02-22T09:05:47.000+0000 false 109812 2026-10-15T19:45:46.551+0000 2025-03-20T09:59:25.625+0000 2010-06-13T19:02:13.000+0000 true 10003154 Wolf György /api/admin/10003154 Admin true 10003154 2026-05-19T11:35:20.113+0000 2026-05-19T11:35:20.113+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Lechan, RM The TRH neuron: a hypothalamic integrator of energy metabolism true true /api/journal/3764 REVIEWED true false 3764 false 3764 true 0079-6123 1875-7855 Journal FOREIGN 153 209 235 209 27 2006 Thyrotropin-releasing hormone (TRH) has an important role in the regulation of energy homeostasis not only through effects on thyroid function orchestrated through hypophysiotropic neurons in the hypothalamic paraventricular nucleus (PVN), but also through central effects on feeding behavior, thermogenesis, locomotor activation and autonomic regulation. Hypophysiotropic TRH neurons are located in the medial and periventricular parvocellular subdivisions of the PVN and receive direct monosynaptic projections from two, separate, populations of leptin-responsive neurons in the hypothalamic arcuate nucleus containing either alpha-melanocyte-stimulating hormone (alpha-MSH) and cocaine- and amphetamine-regulated transcript (CART), peptides that promote weight loss and increase energy expenditure, or neuropeptide Y (NPY) and agouti-related protein (AGRP), peptides that promote weight gain and reduce energy expenditure. During fasting, the reduction in TRH mRNA in hypophysiotropic neurons mediated by suppression of alpha-MSH/CART simultaneously with an increase in NPY/AGRP gene expression in arcuate nucleus neurons contributes to the fall in circulating thyroid hormone levels, presumably by increasing the sensitivity of the TRH gene to negative feedback inhibition by thyroid hormone. Endotoxin administration, however, has the paradoxical effect of increasing circulating levels of leptin and melanocortin signaling and CART gene expression in arcuate nucleus neurons, but inhibiting TRH gene expression in hypophysiotropic neurons. This may be explained by an overriding inhibitory effect of endotoxin to increase type 2 iodothyroine deiodinase (D2) in a population of specialized glial cells, tanycytes, located in the base and infralateral walls of the third ventricle. By increasing the conversion of T4 into T3, tanycytes may increase local tissue concenetrations of thyroid hormone, and thereby induce a state of local tissue hyperthyroidism in the region of hypophysisotrophic TRH neurons. Other regions of the brain may also serve as metabolic sensors for hypophysiostropic TRH neurons including the ventrolateral medulla and dorsomedial nucleus of the hypothalamus that have direct monosynaptic projections to the PVN. TRH also exerts a number of effects within the central nervous system that may contribute to the regulation of energy homeostasis. Included are an increase in core body temperature mediated through neurons in the anterior hypothalamic-preoptic area that coordinate a variety of autonomic responses; arousal and locomotor activation through cholinergic and dopaminergic mechanisms on the septum and nucleus accumbens, respectively; and regulation of the cephalic phase of digestion. While the latter responses are largely mediated through cholinergic mechanisms via TRH neurons in the brainstem medullary raphe and dorsal motor nucleus of the vagus, effects of TRH on autonomic loci in the hypothalamic PVN may also be important. Contrary to the actions of T3 to increase appetite, TRH has central effects to reduce food intake in normal, fasting and stressed animals. The precise locus where TRH mediates this response is unknown. However, evidence that an anatomically separate population of nonhypophysiotropic TRH neurons in the anterior parvocellular subdivision of the PVN is integrated into the leptin regulatory control system by the same arcuate nucleus neuronal populations that innervate hypophysiotropic TRH neurons, raises the possibility that anterior parvocellular TRH neurons may be involved, possibly through interactions with the limbic nervous system. true true 2010 true true true false true false NONE 2026-10-15 false 301 0 301 285 23 298 294 270 296 300 300 284 284 285 16 0 301 285 301 285 0 23 23 Folyóiratcikk Journal Article 24 276 Könyvrészlet Chapter in Book 25 20 Könyv Book 23 5 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Lechan RM </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete C (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;109812" target="_blank">The TRH neuron: a hypothalamic integrator of energy metabolism</a></div> <div> <span class="journal-title">PROGRESS IN BRAIN RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0079-6123">0079-6123</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1875-7855">1875-7855</a>)</span>: <span class="journal-volume">153</span> <span class="page"> pp 209-235 </span> <span class="year">(2006)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/S0079-6123(06)53012-2" target="_blank" href="https://doi.org/10.1016/S0079-6123%2806%2953012-2"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000240722300012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000240722300012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33746308184" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-33746308184"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="16876577" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16876577&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 301</span> | Independent citation: 285 | Self citation: 16 | Unknown citation: 0 | Number of citations in WoS: 270 | Number of citations in Scopus:&nbsp;296 | WoS/Scopus assigned:&nbsp;300 | Number of citations with DOI:&nbsp;294 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;109812&sort=publishedYear,desc&sort=title"> Number of cited publications: 23 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 109812</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 109812</span> | Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.03.20. 10:59 Márta Turek (KOKI admin 4) </div> </div></div>