https://m2.mtmt.hu/ hun 2026-06-27 08:59 JournalArticle 109654 APPROVED true Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, D-76021 Karlsruhe, Germany Department of Anatomy and Developmental Biology, University College London, Gower street, London, WC1E 6BT, United Kingdom Department of Evolutionary Organismal Biology, Evolutionary Biology Centre, Uppsala University, SE-752 36, Uppsala, Sweden Department of Gene Technology and Developmental Neurobiology, Institute for Experimental Medicine, Szigony u. 43, H-1083, Budapest, Hungary Cited By :22 Export Date: 27 April 2020 Correspondence Address: Müller, F.; Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, D-76021 Karlsruhe, Germany; email: ferenc.mueller@itg.fzk.de Chemicals/CAS: cyclopamine, 4449-51-8; cyclopamine, 4449-51-8; Green Fluorescent Proteins, 147336-22-9; Hedgehog Proteins; Veratrum Alkaloids; Zebrafish Proteins 0 2018-05-06T18:04:21.000+0000 false 109654 2026-05-12T15:10:15.849+0000 2022-07-15T10:03:11.637+0000 2010-06-13T18:16:31.000+0000 true 10003154 Wolf György /api/admin/10003154 Admin true 10003154 2025-03-27T11:05:38.600+0000 2025-03-27T11:05:38.600+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hadzhiev, Y Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish true true /api/journal/10002289 REVIEWED true false 10002289 false 10002289 true 1471-213X Journal FOREIGN 7 75 75 12 2007 BACKGROUND: Little is known about the control of the development of vertebrate unpaired appendages such as the caudal fin, one of the key morphological specializations of fishes. Recent analysis of lamprey and dogshark median fins suggests the co-option of some molecular mechanisms between paired and median in Chondrichthyes. However, the extent to which the molecular mechanisms patterning paired and median fins are shared remains unknown. RESULTS: Here we provide molecular description of the initial ontogeny of the median fins in zebrafish and present several independent lines of evidence that Sonic hedgehog signaling emanating from the embryonic midline is essential for establishment and outgrowth of the caudal fin primordium. However, gene expression analysis shows that the primordium of the adult caudal fin does not harbor a Sonic hedgehog-expressing domain equivalent to the Shh secreting zone of polarizing activity (ZPA) of paired appendages. CONCLUSION: Our results suggest that Hedgehog proteins can regulate skeletal appendage outgrowth independent of a ZPA and demonstrates an unexpected mechanism for mediating Shh signals in a median fin primordium. The median fins evolved before paired fins in early craniates, thus the patterning of the median fins may be an ancestral mechanism that controls the outgrowth of skeletogenic appendages in vertebrates. 2010 true true true false true false GOLD GOLD 2026-05-12 true https://doi.org/10.1186/1471-213X-7-75 true 10030885 Bálint Eszter /api/admin/10030885 Admin true 10030885 43 0 43 39 4 43 43 43 43 43 43 39 39 39 4 0 43 39 43 39 0 3 3 Folyóiratcikk Journal Article 24 42 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2008 0 1 0 1 0 2009 0 2 1 2 1 2010 0 4 3 4 3 2011 0 1 1 1 1 2012 0 1 1 1 1 2013 0 2 1 2 1 2014 0 1 1 1 1 2015 0 4 4 4 4 2016 0 3 3 3 3 2017 0 2 2 2 2 2018 0 0 0 0 0 2019 0 2 2 2 2 2020 0 2 2 2 2 2021 0 5 5 5 5 2022 0 4 4 4 4 2023 0 2 2 2 2 2024 0 3 3 3 3 2025 0 4 4 4 4 Q2 false false false false 2010-10-24T23:05:03.000+0000 2013-02-23T19:18:00.000+0000 MTA Kísérleti Orvostudományi Kutatóintézet 2 10 1 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 90095 /api/authorship/90095 1 0.14285715 true false Hadzhiev Y true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17170 true PersonAuthorship 90096 /api/authorship/90096 2 0.143 false false Author 10012357 /api/author/10012357 Lele Zsolt true 10012357 true Lele Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17169 true PersonAuthorship 90097 /api/authorship/90097 3 0.14285715 false false Schindler S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17168 true PersonAuthorship 90098 /api/authorship/90098 4 0.14285715 false false Wilson SW true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17167 true PersonAuthorship 90099 /api/authorship/90099 5 0.14285715 false false Ahlberg P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17166 true PersonAuthorship 90100 /api/authorship/90100 6 0.14285715 false false Strahle U true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17165 true PersonAuthorship 90101 /api/authorship/90101 7 0.14285715 false true Author 10009553 /api/author/10009553 Müller Ferenc DUPLUM true 10009553 true Muller F true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 17164 true PublicationIdentifier 1459582 /api/publicationidentifier/1459582 PlainSource 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http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-34548075253 false 1767799 true PublicationIdentifier 36428 /api/publicationidentifier/36428 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 17597528 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17597528&dopt=Abstract false 11218 true Classification 10545 /api/classification/10545 true true SjrRating 5873147 /api/sjrrating/5873147 20 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1309 /api/classificationexternal/1309 true 1309 true Q2 DIRECT true 5873147 true /api/publication/109654 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Hadzhiev Y </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012357"><a href="/gui2/?type=authors&mode=browse&sel=10012357" target="_blank">Lele Z (<span class="authorship-author-name">Lele Zsolt</span> <span class="authorAux-mtmt"> Fejlődésgenetika, fejlődés-neurobiológia, molek...</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schindler S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wilson SW </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ahlberg P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Strahle U </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009553"><a href="/gui2/?type=authors&mode=browse&sel=10009553" target="_blank">Muller F (<span class="authorship-author-name">Müller Ferenc</span> <span class="authorAux-mtmt"> fejlődés genetika, humán genetika</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;109654" target="_blank">Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish</a></div> <div> <span class="journal-title">BMC DEVELOPMENTAL BIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-213X">1471-213X</a> )</span>: <span class="journal-volume">7</span> <span class="page"> Paper 75. 12 p. </span> <span class="year">(2007)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/1471-213X-7-75" target="_blank" href="https://doi.org/10.1186/1471-213X-7-75"> DOI </a> 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nélkül" class="citingPub-count">Nyilvános idéző összesen: 43</span> | Független: 39 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 43 | Scopus jelölt:&nbsp;43 | WoS/Scopus jelölt:&nbsp;43 | DOI jelölt:&nbsp;43 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;109654&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 109654</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 109654</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2022.07.15. 12:03 Turek Márta (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, D-76021 Karlsruhe, Germany Department of Anatomy and Developmental Biology, University College London, Gower street, London, WC1E 6BT, United Kingdom Department of Evolutionary Organismal Biology, Evolutionary Biology Centre, Uppsala University, SE-752 36, Uppsala, Sweden ...</pre> </div></div>