https://m2.mtmt.hu/ eng 2026-10-23 13:09 JournalArticle 109371 APPROVED true Cited By :1622 Export Date: 11 April 2023 CODEN: NRNAA Correspondence Address: Farrant, M.; Department of Pharmacology, Gower Street, London WC1E 6BT, United Kingdom; email: m.farrant@ucl.ac.uk Chemicals/CAS: 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide, 104104-50-9; benzodiazepine, 12794-10-4; bicuculline, 485-49-4; diazepam, 439-14-5; furosemide, 54-31-9; gaboxadol, 64603-91-4, 85118-33-8; isoflurane, 26675-46-7; midazolam, 59467-70-8; penicillin G, 1406-05-9, 61-33-6; picrotoxin, 124-87-8; propofol, 2078-54-8; vigabatrin, 60643-86-9; zolpidem tartrate, 99294-93-6; zolpidem, 82626-48-0; gamma-Aminobutyric Acid, 56-12-2; Receptors, GABA-A Tradenames: ambien, Sanofi Synthelabo; diprivan, Zeneca; forane, Abbott; l 655708; lasix, Aventis; sabril, sanofi aventis; sr 95531; versed, Hoffmann La Roche Manufacturers: Abbott; Aventis; Hoffmann La Roche; Lundbeck; Merck; sanofi aventis; Sanofi Synthelabo; Zeneca Funding details: Howard Hughes Medical Institute, HHMI Funding details: Boehringer Ingelheim Funding text 1: We thank T. Smart (University College London) for comments on the manuscript, M. Wallner (University of California, Los Angeles) and E. Petrini (Trieste) for sharing data prior to publication, and S. Brickley (Imperial College London) for many helpful discussions during a long collaberation with M.F. M.F.’s research is supported by the Wellcome Trust. Z.N. is the recipient of a Wellcome Trust International Senior Research Fellowship, an International Scholarship from Howard Hughes Medical Institute and a Postdoctoral Fellowship from the Boehringer Ingelheim Fond. 0 2018-05-25T15:20:51.000+0000 false 109371 2026-10-22T08:16:13.657+0000 2025-12-04T11:09:12.394+0000 2010-06-13T13:48:46.000+0000 true 10003154 Wolf György /api/admin/10003154 Admin true 10003154 2026-01-19T10:05:36.072+0000 2026-01-19T10:05:36.072+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Farrant, M Variations on an inhibitory theme: phasic and tonic activation of GABA~A receptors true true /api/journal/30710 REVIEWED true false 30710 false 30710 true 1471-003X 1471-0048 Journal FOREIGN 6 3 215 229 215 15 2005 The proper functioning of the adult mammalian brain relies on the orchestrated regulation of neural activity by a diverse population of GABA (gamma-aminobutyric acid)-releasing neurons. Until recently, our appreciation of GABA-mediated inhibition focused predominantly on the GABA(A) (GABA type A) receptors located at synaptic contacts, which are activated in a transient or 'phasic' manner by GABA that is released from synaptic vesicles. However, there is growing evidence that low concentrations of ambient GABA can persistently activate certain subtypes of GABA(A) receptor, which are often remote from synapses, to generate a 'tonic' conductance. In this review, we consider the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability. true true 2010 true true true false true false NONE 2026-10-22 false true 10030885 Bálint Eszter /api/admin/10030885 Admin true 10030885 1821 0 1821 1812 25 1811 1796 1701 1790 1821 1821 1812 1812 1812 9 0 1821 1812 1821 1812 0 18 18 Folyóiratcikk Journal Article 24 1749 Könyvrészlet Chapter in Book 25 66 Könyv Book 23 6 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2005 0 24 24 24 24 2006 0 63 63 63 63 2007 0 90 89 90 89 2008 0 82 81 82 81 2009 0 86 86 86 86 2010 0 74 74 74 74 2011 0 101 100 101 100 2012 0 94 91 94 91 2013 0 108 108 108 108 2014 0 138 137 138 137 2015 0 89 89 89 89 2016 0 91 90 91 90 2017 0 90 89 90 89 2018 0 96 96 96 96 2019 0 89 89 89 89 2020 0 73 73 73 73 2021 0 101 101 101 101 2022 0 92 92 92 92 2023 0 69 69 69 69 2024 0 61 61 61 61 2025 0 54 54 54 54 2026 0 56 56 56 56 D1 false false false false 2010-08-30T15:20:15.000+0000 2013-02-23T19:18:00.000+0000 Celluláris Idegélettani Kutatócsoport (HRN KOKI) 1 6 1 2 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 88803 /api/authorship/88803 1 0.5 true false true Farrant M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 15198 true PersonAuthorship 88804 /api/authorship/88804 2 0.5 false true Author 10000499 /api/author/10000499 Nusser Zoltán true 10000499 true Nusser Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 15197 true PublicationIdentifier 14719178 /api/publicationidentifier/14719178 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1038/nrn1625 https://doi.org/10.1038/nrn1625 false 10062812 true PublicationIdentifier 35593 /api/publicationidentifier/35593 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000227302300015 https://www.webofscience.com/wos/woscc/full-record/000227302300015 false 1525908 true PublicationIdentifier 35594 /api/publicationidentifier/35594 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 14844323722 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-14844323722 false 1777915 true PublicationIdentifier 35595 /api/publicationidentifier/35595 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 15738957 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15738957&dopt=Abstract false 10858 true Classification 12125 /api/classification/12125 true true SjrRating 5976141 /api/sjrrating/5976141 9 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true D1 DIRECT true 5976141 true /api/publication/109371 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Farrant M ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Z (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;109371" target="_blank">Variations on an inhibitory theme: phasic and tonic activation of GABA~A receptors</a></div> <div> <span class="journal-title">NATURE REVIEWS NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-003X">1471-003X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1471-0048">1471-0048</a>)</span>: <span class="journal-volume">6</span> <span class="journal-issue">3</span> <span class="page"> pp 215-229 </span> <span class="year">(2005)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/nrn1625" target="_blank" href="https://doi.org/10.1038/nrn1625"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000227302300015" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000227302300015"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="14844323722" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-14844323722"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="15738957" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15738957&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1,821</span> | Independent citation: 1,812 | Self citation: 9 | Unknown citation: 0 | Number of citations in WoS: 1,701 | Number of citations in Scopus:&nbsp;1,790 | WoS/Scopus assigned:&nbsp;1,821 | Number of citations with DOI:&nbsp;1,796 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;109371&sort=publishedYear,desc&sort=title"> Number of cited publications: 18 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 109371</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 109371</span> | Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.12.04. 12:09 Ilona Kósa (MTMT központi Admin, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :1622 Export Date: 11 April 2023 CODEN: NRNAA Correspondence Address: Farrant, M.; Department of Pharmacology, Gower Street, London WC1E 6BT, United Kingdom; email: m.farrant@ucl.ac.uk Chemicals/CAS: 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide, 104104-50-9; benzodiaze...</pre> </div></div>