https://m2.mtmt.hu/ hun 2026-10-25 15:53 JournalArticle 1087387 ADMIN_APPROVED true Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, United States Institute of Organic Chemistry, Eotvos L. University, Budapest, Hungary Steaeie Institute of Molecular Sciences, National Research Council of Canada, Ottawa, Canada Cited By :67 Export Date: 20 March 2024 Correspondence Address: OTVOS, L.; Wistar Institute of Anatomy and Biology, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, United States 0 2016-03-14T22:17:57.000+0000 false 1087387 2026-10-13T11:15:01.303+0000 2025-11-25T11:58:59.538+0000 2007-11-07T23:00:00.000+0000 true 10000889 Hollósi Miklós /api/author/10000889 Author true 10000889 2025-11-25T11:58:59.158+0000 2021-06-18T07:09:08.227+0000 true 10069207 Horváth-Solti Rebeka /api/admin/10069207 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Otvos, L Glycosylation of Synthetic Peptides Breaks Helices - Phosphorylation Results IN Distorted Structure true true /api/journal/2081 REVIEWED true false 2081 false 2081 true 0367-8377 Journal FOREIGN 38 5 476 482 476 7 1991 Two proposed glycosylation sites are located within T cell epitopes of rabies virus glycoprotein, namely VVEDEGCTNLSGF (VF13; amino acids 29-41) and GKAYTIFNKTLM (GM12; amino acids 312-323). To explore the effects on peptide conformation due to post-translational modifications, we synthesized glycosylated and phosphorylated versions of the two peptides and compared their structures with the native peptide using CD and FT-IR spectroscopy. After the modifications, i.e., glycosylation on Asn with one or two N-acetyl-glucosamine or glucose residues or phosphorylation on Ser, the low to medium degree of helicity of the unmodified peptides disappears as indicated by CD measurements in water-trifluoroethanol mixtures. Incorporation of one sugar moiety into either peptide resulted with a high probability in a type I (III) beta-turn formation with almost identical spectra for the different peptides. Elongation of the carbohydrate in GM12 only slightly enhanced this effect. In contrast, phosphorylation of VF13 caused distorted conformation of the peptide backbone. This novel and direct demonstration of a change in secondary structure by glycosylation (or phosphorylation) might be an important element in determining peptide antigen structure and function. 2007 true true true false false NONE 2026-10-13 false true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 68 0 68 48 4 67 63 65 65 68 68 48 48 48 20 0 68 48 68 48 0 5 5 Folyóiratcikk Journal Article 24 66 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 1992 0 5 1 5 1 1993 0 2 1 2 1 1994 0 7 3 7 3 1995 0 8 6 8 6 1996 0 7 3 7 3 1997 0 7 6 7 6 1998 0 3 3 3 3 1999 0 3 2 3 2 2000 0 1 0 1 0 2001 0 7 7 7 7 2002 0 2 2 2 2 2003 0 3 2 3 2 2004 0 1 1 1 1 2005 0 1 1 1 1 2006 0 0 0 0 0 2007 0 1 1 1 1 2008 0 2 1 2 1 2009 0 0 0 0 0 2010 0 1 1 1 1 2011 0 2 2 2 2 2012 0 2 2 2 2 2013 0 0 0 0 0 2014 0 1 1 1 1 2015 0 0 0 0 0 2016 0 0 0 0 0 2017 0 0 0 0 0 2018 0 0 0 0 0 2019 0 0 0 0 0 2020 0 0 0 0 0 2021 0 1 1 1 1 2022 0 1 1 1 1 false false false false 2014-03-17T14:48:36.000+0000 2012-07-09T09:35:07.000+0000 Akadémikus bibliográfia; Kiroptikai Szerkezetvizsgáló Laboratórium (KSzL) (ELTE / TTK / KI) 3 15 2 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 461253 /api/authorship/461253 1 0.16666667 true false Author 10010046 /api/author/10010046 Ötvös László true 10010046 true Otvos L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10247058 true PersonAuthorship 461254 /api/authorship/461254 2 0.16666667 false false Thurin J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10247057 true PersonAuthorship 461255 /api/authorship/461255 3 0.16666667 false false Author 10015433 /api/author/10015433 Láng Emma true 10015433 true Kollat E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10247056 true PersonAuthorship 461256 /api/authorship/461256 4 0.16666667 false false Urge L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10247055 true PersonAuthorship 461257 /api/authorship/461257 5 0.16666667 false false Mantsch HH true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10247054 true PersonAuthorship 461258 /api/authorship/461258 6 0.167 false true Author 10000889 /api/author/10000889 Hollósi Miklós true 10000889 true Hollosi M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10247053 true Institute 19040 /api/institute/19040 0 false false true Akadémikus bibliográfia Bibliografy of Hungarian of Academy of Sciences' academicians true 19040 true PublicationIdentifier 25889613 /api/publicationidentifier/25889613 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1111/j.1399-3011.1991.tb01529.x https://doi.org/10.1111/j.1399-3011.1991.tb01529.x false true PublicationIdentifier 150829 /api/publicationidentifier/150829 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL A1991GT97400010 https://www.webofscience.com/wos/woscc/full-record/A1991GT97400010 false 67908 true PublicationIdentifier 150830 /api/publicationidentifier/150830 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 0026355815 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0026355815 false 1331575 true PublicationIdentifier 14979508 /api/publicationidentifier/14979508 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 1724974 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1724974&dopt=Abstract false 11449238 true Classification 10545 /api/classification/10545 true true /api/publication/1087387 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10010046"><a href="/gui2/?type=authors&mode=browse&sel=10010046" target="_blank">Otvos L (<span class="authorship-author-name">Ötvös László</span> <span class="authorAux-mtmt"> Peptidek kémiája és biokémiája</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Thurin J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015433"><a href="/gui2/?type=authors&mode=browse&sel=10015433" target="_blank">Kollat E (<span class="authorship-author-name">Láng Emma</span> <span class="authorAux-mtmt"> Peptidkémia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Urge L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mantsch HH </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000889"><a href="/gui2/?type=authors&mode=browse&sel=10000889" target="_blank">Hollosi M (<span class="authorship-author-name">Hollósi Miklós</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Kémiai Intézet">KI</span>/Kiroptikai Szerkezetvizsgáló Laboratórium (KSzL)</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1087387" target="_blank">Glycosylation of Synthetic Peptides Breaks Helices - Phosphorylation Results IN Distorted Structure</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0367-8377">0367-8377</a> )</span>: <span class="journal-volume">38</span> <span class="journal-issue">5</span> <span class="page"> pp 476-482 </span> <span class="year">(1991)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/j.1399-3011.1991.tb01529.x" target="_blank" href="https://doi.org/10.1111/j.1399-3011.1991.tb01529.x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="A1991GT97400010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/A1991GT97400010"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0026355815" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0026355815"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="1724974" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1724974&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 68</span> | Független: 48 | Függő: 20 | Nem jelölt: 0 | WoS jelölt: 65 | Scopus jelölt:&nbsp;65 | WoS/Scopus jelölt:&nbsp;68 | DOI jelölt:&nbsp;63 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1087387&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1087387</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> <span class="oldId">Régi azonosító: 1087387</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="special-affiliations"> Speciális affiliáció: Akadémikus bibliográfia </div> <div class="lastModified">Utolsó módosítás: 2025.11.25. 12:58 Szabó Regina (ELTE TTK admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, United States Institute of Organic Chemistry, Eotvos L. University, Budapest, Hungary Steaeie Institute of Molecular Sciences, National Research Council of Canada, Ottawa, Canada Cited By :67 Export Date: 20 March 2024 ...</pre> </div></div>