https://m2.mtmt.hu/ hun 2026-10-24 19:48 JournalArticle 1087384 APPROVED true Institute of Organic Chemistry, L. Eötvös University, Budapest, H-1518, Hungary Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts, 02254-9110, United States Cited By :23 Export Date: 13 May 2024 Correspondence Address: Hollósi, M.; Institute of Organic Chemistry, , Budapest, H-1518, Hungary 0 2014-08-14T19:26:22.000+0000 false 1087384 2026-10-13T11:14:59.297+0000 2025-07-02T01:55:52.102+0000 2007-11-07T23:00:00.000+0000 true 10000889 Hollósi Miklós /api/author/10000889 Author true 10000889 2025-07-02T01:55:52.301+0000 2025-07-02T01:55:52.301+0000 2014-03-17T14:48:36.000+0000 true 10020539 Hegyi Judit /api/admin/10020539 Admin true 10020539 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hollosi, M Chiroptical Labeling of Folded Polypeptide Conformations - The Thioamide Probe true true /api/journal/745 REVIEWED true false 745 false 745 true 0006-3525 1097-0282 Journal FOREIGN 30 11-12 1061 1072 1061 12 1990 This paper reports the chiroptical properties of thionated N-acyl amino acid and N-acyl dipeptide N'-methylamide models. It was found that the optical activity of the thioamide chromophore is dominated by the chiral contribution of perturbants attached to C-alpha at the N-H side of the thioamide group. The appearance of a strong negative pi-pi* band near 270 nm is indicative of the semiextended conformation of this residue. The phi approximately -70-degrees, psi greater-than-or-equal-to 120-degrees set of torsion angles is compatible with a type II beta-t-turn or a gamma-t-turn conformation with the perturbing N-H side residue in the i + 1 position of the turn. (The subscript t or tt denotes that one or both of the H-bonded moieties is thioamide.) Earlier data show that both beta-t- and gamma-t-turns may be fixed by C = S ... H-N(CO) intramolecular H bonds. The appearance of one or two weak n-pi* bands and a positive pi-pi* band at about 270 nm is characteristic of type II beta-t-turns containing the H-bonded thioamide group attached to the glycine residue in position i + 2. The extended conformation (phi approximately -140-degrees, psi approximately 140-degrees) of a residue after the thioamide group gives rise to a negative n-pi* and a positive pi-pi* band of comparable magnitude. Peptide sequences with alternating thioamide-amide-thioamide backbone tend to adopt 1t <-- 4t H-bonded beta-tt conformations. CD studies show that type II beta-tt-turns have unique chiroptical properties: the pi-pi* region is dominated by an exceedingly strong negative band near 260 nm (DELTA-epsilon = 19-24) accompanied by a weaker band at higher wavelength values. 2007 true true true false false NONE 2026-10-13 false 26 0 26 21 1 24 18 19 12 19 19 16 16 21 5 0 26 21 26 21 0 3 3 Folyóiratcikk Journal Article 24 26 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 1993 0 1 1 1 1 1994 0 2 2 2 2 1995 0 4 0 4 0 1996 0 1 1 1 1 1997 0 0 0 0 0 1998 0 0 0 0 0 1999 0 2 2 2 2 2000 0 0 0 0 0 2001 0 2 2 2 2 2002 0 0 0 0 0 2003 0 1 0 1 0 2004 0 0 0 0 0 2005 0 0 0 0 0 2006 0 0 0 0 0 2007 0 0 0 0 0 2008 0 1 1 1 1 2009 0 0 0 0 0 2010 0 0 0 0 0 2011 0 0 0 0 0 2012 0 2 2 2 2 2013 0 2 2 2 2 2014 0 3 3 3 3 2015 0 1 1 1 1 2016 0 0 0 0 0 2017 0 0 0 0 0 2018 0 0 0 0 0 2019 0 1 1 1 1 2020 0 0 0 0 0 2021 0 1 1 1 1 2022 0 1 1 1 1 2023 0 0 0 0 0 2024 0 1 1 1 1 false false false false 2014-03-17T14:48:36.000+0000 2012-07-09T09:35:40.000+0000 Akadémikus bibliográfia; Kiroptikai Szerkezetvizsgáló Laboratórium (KSzL) (ELTE / TTK / KI) 2 11 2 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 461235 /api/authorship/461235 1 0.2 true false Author 10000889 /api/author/10000889 Hollósi Miklós true 10000889 true Hollosi M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10247039 true PersonAuthorship 461236 /api/authorship/461236 2 0.2 false false Author 10015433 /api/author/10015433 Láng Emma true 10015433 true Kollat E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10247038 true PersonAuthorship 461237 /api/authorship/461237 3 0.2 false false Kajtar J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10247037 true PersonAuthorship 461238 /api/authorship/461238 4 0.2 false false Kajtar M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10247036 true PersonAuthorship 461239 /api/authorship/461239 5 0.2 false true Fasman GD true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10247035 true Institute 19040 /api/institute/19040 0 false false true Akadémikus bibliográfia Bibliografy of Hungarian of Academy of Sciences' academicians true 19040 true PublicationIdentifier 150821 /api/publicationidentifier/150821 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1002/bip.360301107 https://doi.org/10.1002/bip.360301107 false 67902 true PublicationIdentifier 150820 /api/publicationidentifier/150820 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL A1990EW56300006 https://www.webofscience.com/wos/woscc/full-record/A1990EW56300006 false 67903 true PublicationIdentifier 14690037 /api/publicationidentifier/14690037 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 0025696905 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0025696905 false 17245046 true Classification 11027 /api/classification/11027 true true Classification 10545 /api/classification/10545 true true Classification 12548 /api/classification/12548 true true Classification 10799 /api/classification/10799 true true Classification 10293 /api/classification/10293 true true /api/publication/1087384 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10000889"><a href="/gui2/?type=authors&mode=browse&sel=10000889" target="_blank">Hollosi M (<span class="authorship-author-name">Hollósi Miklós</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Kémiai Intézet">KI</span>/Kiroptikai Szerkezetvizsgáló Laboratórium (KSzL)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015433"><a href="/gui2/?type=authors&mode=browse&sel=10015433" target="_blank">Kollat E (<span class="authorship-author-name">Láng Emma</span> <span class="authorAux-mtmt"> Peptidkémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Kémiai Intézet">KI</span>/Kiroptikai Szerkezetvizsgáló Laboratórium (KSzL)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kajtar J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kajtar M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fasman GD </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1087384" target="_blank">Chiroptical Labeling of Folded Polypeptide Conformations - The Thioamide Probe</a></div> <div> <span class="journal-title">BIOPOLYMERS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0006-3525">0006-3525</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-0282">1097-0282</a>)</span>: <span class="journal-volume">30</span> <span class="journal-issue">11-12</span> <span class="page"> pp 1061-1072 </span> <span class="year">(1990)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/bip.360301107" target="_blank" href="https://doi.org/10.1002/bip.360301107"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="A1990EW56300006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/A1990EW56300006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0025696905" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0025696905"> Scopus </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 26</span> | Független: 21 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 19 | Scopus jelölt:&nbsp;12 | WoS/Scopus jelölt:&nbsp;19 | DOI jelölt:&nbsp;18 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1087384&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1087384</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 1087384</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="special-affiliations"> Speciális affiliáció: Akadémikus bibliográfia </div> <div class="lastModified">Utolsó módosítás: 2025.07.02. 03:55 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute of Organic Chemistry, L. Eötvös University, Budapest, H-1518, Hungary Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts, 02254-9110, United States Cited By :23 Export Date: 13 May 2024 Correspondence Address: Hollósi, M.; Institute of Organic Chemistry, , Buda...</pre> </div></div>