https://m2.mtmt.hu/ eng 2026-10-24 08:20 JournalArticle 107792 APPROVED true 0 2018-09-12T12:19:44.000+0000 false 107792 2026-10-12T19:01:57.095+0000 2024-12-06T09:24:10.922+0000 2010-06-13T07:11:59.000+0000 true 10003154 Wolf György /api/admin/10003154 Admin György Wolf (KOKI admin) true 10003154 2026-01-12T09:23:14.165+0000 2026-01-12T09:23:14.165+0000 Admin 10067876 /api/admin/10067876 Gusztáv Ladányi (MTMT API user, admin) Ladányi Gusztáv true true 2025-01-02T11:59:26.292+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Elenkov, IJ true true /api/journal/2699 REVIEWED JOURNAL OF NEUROIMMUNOLOGY 0165-5728 1872-8421 true false 2699 false 2699 true 0165-5728 1872-8421 Journal FOREIGN 61 2 123 131 123 9 1995 In a previous study we demonstrated that mice pretreated with the highly selective α2-adrenoceptor antagonist CH-38083 showed blunting of the tumor necrosis factor-α (TNF-α) response induced by bacterial lipopolysaccharide (LPS). In the present study, the effect of a selective block of α2-adrenoreceptor and the role of the sympathetic nervous system (SNS) in the regulation of LPS-induced TNF-α production was explored further using different selective adrenoceptor antagonists and agonists. While adrenalectomy did not prevent the effect of CH-38083, the block of the sympathetic transmission by chlorisondamine fully abolished the inhibitory effect of CH-38083 on LPS-induced TNF-α production, suggesting that the effect of the α2-adrenoceptor blocking agent is corticosteroid-independent, but it requires intact sympathetic activity. Since the selective block of α2-adrenoceptors results in an increased sympathetic activity and an increase of the release of noradrenaline (NA) in both the central and the peripheral nervous systems, and in our experiments propranolol, a non-selective β-adrenoceptor antagonist, and atenolol, a selective antagonist of β1-adrenoceptors, prevented the effect of α2-adrenoceptor blockade by CH-38083 of the TNF-α response induced by LPS, it seems likely that the excessive stimulation by NA of β1-adrenoceptors is responsible for this action. The role of β-adrenoceptors and endogenous catecholamines is further substantiated by the finding that pretreatment of animals with propranolol alone resulted in a dose-dependent increase of the TNF-α response induced by LPS, and that isoproterenol, a non-selective β-adrenoceptor agonist, decreased it. Additionally, it was shown that prazosin, an α1-and α2B-adrenoceptor antagonist, reduced LPS-induced TNF-α production. However, l-phenylephrine, a selective α1-adrenoceptor agonist, was not able to modulate the TNF-α response following LPS challenge. Our findings that α2-and β-adrenoceptor antagonists are able to decrease or increase, respectively, the TNF-α response elicited by LPS indicate that SNS, through release of endogenous catecholamines, is involved in vivo in the regulation of LPS-induced TNF-α production. In this process, the β-adrenoceptor-mediated events seems to play a pivotal role. Since the blockade of sympathetic activity by chlorisondamine failed to affect LPS-induced TNF-α release, it seems likely that, in vivo, the inhibitory effect of SNS on TNF-α production, mediated via β-adrenoceptors, is opposed by an effect of catecholamines on α2-adrenoceptors. It is suggested that the fine-tuning of TNF-α release exerted by SNS in vivo might be particularly important during immunological and non-immunological stress, when the concentration of catecholamines is increased in the close proximity of TNF-α-secreting cells, which are known to possess adrenoceptors. true true 2010 true true true false true false NONE 2026-10-12 false true 10030885 Bálint Eszter /api/admin/10030885 Admin Eszter Bálint (MTMT Közp admin) true 10030885 177 0 177 139 29 176 167 161 165 176 176 138 138 139 38 0 177 139 177 139 0 10 10 Folyóiratcikk Journal Article 24 172 Könyvrészlet Chapter in Book 25 5 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 1996 0 4 2 4 2 1997 0 8 3 8 3 1998 0 10 2 10 2 1999 0 10 7 10 7 2000 0 17 10 17 10 2001 0 10 7 10 7 2002 0 9 6 9 6 2003 0 6 5 6 5 2004 0 8 8 8 8 2005 0 9 9 9 9 2006 0 9 9 9 9 2007 0 8 6 8 6 2008 0 9 7 9 7 2009 0 2 2 2 2 2010 0 7 7 7 7 2011 0 4 4 4 4 2012 0 2 2 2 2 2013 0 1 1 1 1 2014 0 6 6 6 6 2015 0 5 5 5 5 2016 0 3 3 3 3 2017 0 1 0 1 0 2018 0 4 4 4 4 2019 0 3 3 3 3 2020 0 7 6 7 6 2021 0 1 1 1 1 2022 0 5 5 5 5 2023 0 2 2 2 2 2024 0 3 3 3 3 2025 0 3 3 3 3 2026 0 1 1 1 1 false false false false 2013-05-24T18:18:00.000+0000 2013-02-23T19:18:00.000+0000 Farmakológiai Kutatócsoport (KOKI / GYO); MTA Kísérleti Orvostudományi Kutatóintézet 3 21 2 4 0 true 10067876 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 83617 /api/authorship/83617 Elenkov, IJ 1 0.25 true false Elenkov IJ true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 6877 true PersonAuthorship 83618 /api/authorship/83618 Haskó, Gy [Haskó, György (Immunofarmakológia), author] MTA Kísérleti Orvostudományi Kutatóintézet 2 0.25 false false Author 10011499 /api/author/10011499 György Haskó (Immunofarmakológia) Haskó György true 10011499 true Haskó Gy true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 6876 true PersonAuthorship 83619 /api/authorship/83619 Kovács, KJ [Kovács, Krisztina (Neuroendokrinológia), author] MTA Kísérleti Orvostudományi Kutatóintézet 3 0.25 false false Author 10009124 /api/author/10009124 Krisztina Kovács (Neuroendokrinológia) Kovács Krisztina true 10009124 true Kovács KJ true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 6875 true PersonAuthorship 83620 /api/authorship/83620 Vizi, ES ✉ [Vizi, E. Szilveszter (Neurofarmakológia...), author] Laboratory of Drug Research (IEM / DP) 4 0.25 false true true Author 10000023 /api/author/10000023 E. Szilveszter Vizi (Neurofarmakológia, neurokémia) Vizi E. Szilveszter true 10000023 true Vizi ES true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 6874 true PublicationIdentifier 33115 /api/publicationidentifier/33115 DOI: 10.1016/0165-5728(95)00080-L PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1016/0165-5728(95)00080-L https://doi.org/10.1016/0165-5728%2895%2900080-L false 594257 true PublicationIdentifier 33113 /api/publicationidentifier/33113 WoS: A1995TB63200003 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL A1995TB63200003 https://www.webofscience.com/wos/woscc/full-record/A1995TB63200003 false 594258 true PublicationIdentifier 33114 /api/publicationidentifier/33114 Scopus: 0028866572 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 0028866572 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0028866572 false 1824402 true PublicationIdentifier 33116 /api/publicationidentifier/33116 PubMed: 7593548 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 7593548 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7593548&dopt=Abstract false 9645 true Classification 12125 /api/classification/12125 Basic medicine true true Classification 10545 /api/classification/10545 Biological sciences true true Classification 12146 /api/classification/12146 Immunology true true Classification 12189 /api/classification/12189 Clinical Pharmacology true true Classification 12215 /api/classification/12215 Clinical medicine true true /api/publication/107792 Elenkov IJ et al. Modulation of lipopolysaccharide-induced tumor necrosis factor-α production by selective α- and ß-adrenergic drugs in mice. (1995) JOURNAL OF NEUROIMMUNOLOGY 0165-5728 1872-8421 61 2 123-131<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Elenkov IJ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011499"><a href="/gui2/?type=authors&mode=browse&sel=10011499" target="_blank">Haskó Gy (<span class="authorship-author-name">Haskó György</span> <span class="authorAux-mtmt"> Immunofarmakológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009124"><a href="/gui2/?type=authors&mode=browse&sel=10009124" target="_blank">Kovács KJ (<span class="authorship-author-name">Kovács Krisztina</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000023"><a href="/gui2/?type=authors&mode=browse&sel=10000023" target="_blank">Vizi ES ✉ (<span class="authorship-author-name">Vizi E. Szilveszter</span> <span class="authorAux-mtmt"> Neurofarmakológia, neurokémia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Drug Research</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;107792" target="_blank">Modulation of lipopolysaccharide-induced tumor necrosis factor-α production by selective α- and ß-adrenergic drugs in mice</a></div> <div> <span class="journal-title">JOURNAL OF NEUROIMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0165-5728">0165-5728</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1872-8421">1872-8421</a>)</span>: <span class="journal-volume">61</span> <span class="journal-issue">2</span> <span class="page"> pp 123-131 </span> <span class="year">(1995)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/0165-5728(95)00080-L" target="_blank" href="https://doi.org/10.1016/0165-5728%2895%2900080-L"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="A1995TB63200003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/A1995TB63200003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0028866572" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0028866572"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="7593548" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7593548&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 177</span> | Independent citation: 139 | Self citation: 38 | Unknown citation: 0 | Number of citations in WoS: 161 | Number of citations in Scopus:&nbsp;165 | WoS/Scopus assigned:&nbsp;176 | Number of citations with DOI:&nbsp;167 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;107792&sort=publishedYear,desc&sort=title"> Number of cited publications: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 107792</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 107792</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2024.12.06. 10:24 Barbara Bodnár (MTMT ellenőrzés admin5) </div> <div class="lockedBy">Centrally managed 2025.01.02. 12:59 Gusztáv Ladányi (MTMT API user, admin) </div> </div></div>