Anti platelet antibodies against gpIIb/IIIa in systemic sclerosis

Czirják, L [Czirják, László (Immunológia), szerző]; Molnár, I [Molnár, Ildikó (Klinikai endokrin...), szerző]; Csipő, I [Csípő, István (immunológia), szerző] C épület (DE / KK / BelgyKL); Szabolcs, M; Mihály, A; Szegedi, G [Szegedi, Gyula (Belgyógyászat), szerző] C épület (DE / KK / BelgyKL)

Angol nyelvű Tudományos Rövid közlemény (Folyóiratcikk)
    Azonosítók
    Szakterületek:
      An enzyme-linked immunosorbent assay and western immunoblotting analysis were used to detect anti-platelet antibodies in the sera of 50 patients with systemic sclerosis. Eleven (22%) positive sera were found by ELISA. Serial investigations showed that the presence of these antibodies was often transient. Immunoblotting analysis demonstrated that the antibodies were directed against a 114 kDa antigen. Using monoclonal antibody, anti-platelet antibodies directed against gpIIIa were found in 4 cases. Similar to immune thrombocytopenia and lupus erythematosus, a significant portion of the anti-platelet antibodies were also directed against the glycoprotein complex IIb/IIIa in systemic sclerosis.
      Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
      2021-02-26 17:42