Synthesis and structure of cycloalkane- and norbornane-condensed 6-aryl-1,2,4,5-tetrahydropyridazinones

Csende, F; Hetenyi, A [Hetényi, Anasztázia (NMR spektroszkópi...), author] Department of Pharmaceutical Chemistry (USZ / FP); Stajer, G [Stájer, Géza (Szerves kémia és ...), author] Department of Pharmaceutical Chemistry (USZ / FP); Fulop, F [Fülöp, Ferenc (Kémia), author] Department of Pharmaceutical Chemistry (USZ / FP)

English Scientific Article (Journal Article)
Published: JOURNAL OF HETEROCYCLIC CHEMISTRY 0022-152X 41 (2) pp. 259-261 2004
  • SJR Scopus - Organic Chemistry: Q3
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    The Cdouble bondN double bond of certain cis- or trans-cycloalkane and diexo- or diendo-norbornane-condensed pyridazinones was reduced with NaBH3CN. The cis- or trans nature of the starting cycloalkane derivatives was always retained in the saturated products, with a high degree of diastereoselectivity: the hydrogen on the new stereocenter and the annelational hydrogen next to the carbonyl always exhibited the same steric orientation. The stereostructures were determined by means of nmr measurements and confirmed by molecular modelling.
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    2020-09-26 08:37