Ihász M et al. A laparoscopos cholecystectomia és az epeútsérülések. 26440 hazai műtét tapasztalatainak elemzése. (1996) ORVOSI HETILAP 0030-6002 1788-6120 137 18 955-963,
1819460
Szakcikk (Folyóiratcikk) | Tudományos[1819460]
Ayloo Subhashini et al. Robotic cholecystectomy: training of residents in use of the robotic platform. (2014) INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY 1478-5951 1478-596X 10 1 88-92
Buzas G M. The role of orvosi hetilap in the development of contemporary hungarian gastroenterology. part 4: 1989-2008: Az orvosi hetilap szerepe a kortárs magyar gasztroenterológia kialakulásában. 4. rész: 1989-2008. (2009) ORVOSI HETILAP 0030-6002 1788-6120 150 15 703-709
Kajzrlíková I et al. Abdominal ultrasound accurately detects complications in patients with hepaticojejunoanastomosis. (2009) SCRIPTA MEDICA 1211-3395 82 4 239-248
Sandor József et al. Why laparoscopic cholecystectomy today?. (1996) SURGERY TODAY 0941-1291 1436-2813 26 7 556-560,
1786215
Szakcikk (Folyóiratcikk) | Tudományos[1786215]
Bhalla Jyoti et al. Comparison of palanosetron with ondansetron for postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy under general anesthesia. (2015) JOURNAL OF MINIMAL ACCESS SURGERY 0972-9941 1998-3921 11 3 193-197
Wu Si-Jia et al. Comparison of the Efficacy of Ondansetron and Granisetron to Prevent Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Systematic Review and Meta-Analysis. (2013) SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES 1530-4515 1534-4908 23 1 79-87
Gautam B et al. Antiemetic prophylaxis against postoperative nausea and vomiting with ondansetron-dexamethasone combination compared to ondansetron or dexamethasone alone for patients undergoing laparoscopic cholecystectomy. (2008) KATHMANDU UNIVERSITY MEDICAL JOURNAL 1812-2027 1812-2078 6 23 319-328
Hazinedaroglu S M et al. Intraperitoneal bupivacaine for postoperative pain relief after laparoscopic cholecystectomy. (2006) PAIN MEDICINE 1526-2375 1526-4637 7 6 539-541
Rövid közlemény (Folyóiratcikk) | Tudományos[22092389] [Admin láttamozott]
Lee K -T et al. Verres needle decompression of distended gallbladder to facilitate laparoscopic cholecystectomy in acute cholecystitis: A prospective study. (2005) HEPATO-GASTROENTEROLOGY 0172-6390 52 65 1388-1392
Lien H -H et al. Management of bile leakage after laparoscopic cholecystectomy based on etiological classification. (2004) SURGERY TODAY 0941-1291 1436-2813 34 4 326-330
Wang J -J et al. Small-dose dexamethasone reduces nausea and vomiting after laparoscopic cholecystectomy: A comparison of tropisetron with saline. (2002) ANESTHESIA AND ANALGESIA 0003-2999 1526-7598 95 1 229-232
Wang J J et al. Dexamethasone reduces nausea and vomiting after laparoscopic cholecystectomy. (1999) BRITISH JOURNAL OF ANAESTHESIA 0007-0912 1471-6771 83 5 772-775
Gürleyik E et al. Does chemical composition have an influence on the fate of intraperitoneal gallstone in rat?. (1998) SURGICAL LAPAROSCOPY & ENDOSCOPY 1051-7200 2331-2254 8 2 113-116
Regoly-Merei J et al. Biliary tract complications in laparoscopic cholecystectomy - A multicenter study of 148 biliary tract injuries in 26,440 operations. (1998) SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 0930-2794 1432-2218 12 4 294-300,
1786214
Szakcikk (Folyóiratcikk) | Tudományos[1786214]
Kurauchi Nobuaki et al. Gallbladder and common bile duct. (2024) ASIAN JOURNAL OF ENDOSCOPIC SURGERY 1758-5902 1758-5910 17 4
Bickel A. et al. The Role of Hepatobiliary Scintigraphy as the Initial Investigative Modality for Significant Bile Leak following Laparoscopic Cholecystectomy. (2023) DIGESTIVE SURGERY 0253-4886 1421-9883 40 5 178-186
Dip Fernando et al. Does near-infrared fluorescent cholangiography with indocyanine green reduce bile duct injuries and conversions to open surgery during laparoscopic or robotic cholecystectomy? d A meta-analysis. (2021) SURGERY 0039-6060 1532-7361 169 4 859-867
Borie Frederic et al. The Cost and the Effectiveness of Cholangiography for the Diagnosis and Treatment of a Bile Duct Injury After Difficult Identification of the Cystic Duct. (2020) JOURNAL OF GASTROINTESTINAL SURGERY 1091-255X 1873-4626
Ayloo Subhashini et al. Robotic cholecystectomy: training of residents in use of the robotic platform. (2014) INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY 1478-5951 1478-596X 10 1 88-92
中华医学会外科学分会胆道外科学组. Pract95ice guideline for diagnosis and treatment of bile duct injury (2013 edition) Biliary Surgery Group of Surgery Branch of Chinese Medical Association. (2013) ZHONGHUA XIAOHUA WAIKE ZAZHI / CHINESE JOURNAL OF DIGESTIVE SURGERY 1673-9752 2709-1767 12 2 081-095
Bilimoria Karl Y et al. Laparoscopic Cholecystectomy, Intraoperative Cholangiograms, and Common Duct Injuries. (2013) JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 0098-7484 1538-3598 310 8 801-802
Slim K et al. Does routine intra-operative cholangiography reduce the risk of biliary injury during laparoscopic cholecystectomy? An evidence-based approach. (2013) JOURNAL OF VISCERAL SURGERY 1878-7886 1878-7886 150 5 321-324
Sheffield Kristin M et al. Association Between Cholecystectomy With vs Without Intraoperative Cholangiography and Risk of Common Duct Injury. (2013) JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 0098-7484 1538-3598 310 8 812-820
Navez Benoit et al. Surgical management of acute cholecystitis: results of a 2-year prospective multicenter survey in Belgium. (2012) SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 0930-2794 1432-2218 26 9 2436-2445
Sokszerzős vagy csoportos szerzőségű szakcikk (Folyóiratcikk) | Tudományos[22792766] [Admin láttamozott]
Ausania F et al. Intraoperative cholangiography in the laparoscopic cholecystectomy era: why are we still debating?. (2012) SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 0930-2794 1432-2218 26 5 1193-1200
Braghetto I et al. Correlación ecográfica-laparoscópica en colecistitis crónica y aguda. Validación 10 años después [Ultrasonographic and laparoscopic correlation in acute and chronic cholecystitis. 10 years later validation]. (2011) REVISTA CHILENA DE CIRUGIA 0379-3893 0718-4026 63 2 170-177
Karvonen J et al. Bile duct injuries during open and laparoscopic cholecystectomy in the laparoscopic era: alarming trends. (2011) SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 0930-2794 1432-2218 25 9 2906-2910
Cannon R M et al. A novel classification system to address financial impact and referral decisions for bile duct injury in laparoscopic cholecystectomy. (2011) HPB SURGERY 0894-8569 1607-8462 2011
Manterola C et al. Efectividad de la cirugía laparoscópica para colecistolitiasis y coledocolitiasis: Revisión global de la evidencia [Effectiveness of Laparoscopic Surgery for Gallstones and Common Bile Duct Lithiasis: a Systematic Overview]. (2010) INTERNATIONAL JOURNAL OF MORPHOLOGY 0717-9367 0717-9502 28 3 729-742
Buzas G M. The role of orvosi hetilap in the development of contemporary hungarian gastroenterology. part 4: 1989-2008: Az orvosi hetilap szerepe a kortárs magyar gasztroenterológia kialakulásában. 4. rész: 1989-2008. (2009) ORVOSI HETILAP 0030-6002 1788-6120 150 15 703-709
Priego P et al. Results of laparoscopic cholecystectomy in a third-level university hospital after 17 years of experience. (2009) REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS 1130-0108 2340-4167 101 1 20-30
Liu JJ et al. Evaluation of real-time infrared intraoperative cholangiography in a porcine model. (2008) SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 0930-2794 1432-2218 22 12 2659-2664
Puche P et al. Traitement des complications biliaires après cholécystectomie par cœlioscopie: Étude rétrospective de 27 patients [Treatment of biliary injuries after laparoscopic cholecystectomy : Retrospective study of 27 patients]. (2007) JOURNAL DE CHIRURGIE 0021-7697 1773-0422 144 5 403-408
Salih Mohammad et al. Endoscopic management of biliary leaks after open and laparoscopic cholecystectomy. (2007) JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION 0030-9982 0030-9982 57 3 117-119
Karvonen J et al. Bile duct injuries during laparoscopic cholecystectomy: primary and long-term results from a single institution. (2007) SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 0930-2794 1432-2218 21 7 1069-1073
De Silva W M et al. Biliary tract injury during cholecystectomy: a retrospective descriptive review of clinical features, treatment and outcome. (2006) CEYLON MEDICAL JOURNAL 0009-0875 0009-0875 51 4 132-136
Manson J. Bile duct injury in the era of laparoscopic cholecystectomy (Br J Surg 2006; 93 : 158-168). (2006) BRITISH JOURNAL OF SURGERY 0007-1323 1365-2168 93 5 640-640
Mouzas IA et al. Bile leakage presenting as acute abdomen due to a stone created around a migrated surgical clip. (2005) MEDICAL SCIENCE MONITOR 1234-1010 1643-3750 11 3 CS16-CS18
Nuzzo G et al. Bile duct injury during laparoscopic cholecystectomy - Results of an Italian national survey on 56,591 cholecystectomies. (2005) ARCHIVES OF SURGERY 0004-0010 1538-3644 2168-6262 140 10 986-992
Shamiyeh A et al. Laparoscopic cholecystectomy: early and late complications and their treatment. (2004) LANGENBECKS ARCHIVES OF SURGERY 1435-2443 1435-2451 389 3 164-171
Ludwig K et al. Die intraoperative laparoskopische cholangiografie - Wann ist sie sinnvoll? [Intraoperative laparoscopic cholangiography - When is it useful?]. (2004) ZENTRALBLATT FUR CHIRURGIE 0044-409X 1438-9592 129 3 185-190
Mercado MA. De Langenbuch a Strasberg: El espectro de las lesiones de vías biliares [From Langenbuch to Strasberg: The spectrum of bile duct injuries]. (2004) REVISTA DE INVESTIGACION CLINICA: THE OFFICIAL JOURNAL OF THE NATIONAL INSTITUTES OF HEALTH OF MEXICO 0034-8376 2385-3956 56 5 649-664
Gentileschi P et al. Bile duct injuries during laparoscopic cholecystectomy - A 1994-2001 audit on 13,718 operations in the area of Rome. (2004) SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 0930-2794 1432-2218 18 2 232-236
Huscher CGS et al. Laparoscopic cholecystectomy by ultrasonic dissection without cystic duct and artery ligature. (2003) SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 0930-2794 1432-2218 17 3 442-451
Gronroos JM et al. Is male gender a risk factor for bile duct injury during laparoscopic cholecystectomy?. (2003) LANGENBECKS ARCHIVES OF SURGERY 1435-2443 1435-2451 388 4 261-264
Ludwig K et al. Value and consequences of routine intraoperative cholangiography during cholecystectomy. (2002) SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES 1530-4515 1534-4908 12 3 154-159
Christoforidis E et al. The endoscopic management of persistent bile leakage after laparoscopic cholecystectomy. (2002) SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 0930-2794 1432-2218 16 5 843-846
Gómez N A et al. Repair of bile duct injuries with Gore-Tex vascular grafts: Experimental study in dogs. (2002) JOURNAL OF GASTROINTESTINAL SURGERY 1091-255X 1873-4626 6 1 116-120
Michek J et al. New classification of major bile duct injuries associated with laparoscopic cholecystectomy. (2002) SCRIPTA MEDICA 1211-3395 75 6 283-290
Ludwig K et al. Gallenwegsverletzungen bei laparoskopischer cholezystektomie [Injuries of the common bile duct during laparoscopic cholecystectomy]. (2002) VISZERALCHIRURGIE 1435-3067 1439-1643 37 1 61-66
Crema E et al. Excluded-loop hepatojejunal anastomosis with use of laparoscopy in late management of iatrogenic ligature of the bile duct. (2002) SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES 1530-4515 1534-4908 12 2 110-114
Bonde P et al. Endoscopic vein harvest: Early results of a prospective trial with open vein harvest. (2002) HEART SURGERY FORUM 1098-3511 1522-6662 5 Suppl. 4 378-391
Ludwig K et al. Contribution of intraoperative cholangiography to incidence and outcome of common bile duct injuries during laparoscopic cholecystectomy. (2002) SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 0930-2794 1432-2218 16 7 1098-1104
Di Visconte M S. Analysis of pathogenetic mechanisms of common bile duct iatrogenic lesion during laparoscopic cholecystectomy: A review of the literature. (2002) MINERVA CHIRURGICA 0026-4733 1827-1626 57 5 663-667
Aoki T et al. Strategies for Management of Bile Duct Injury during Laparoscopic Cholecystectomy. (2001) DIAGNOSTIC AND THERAPEUTIC ENDOSCOPY 1070-3608 1029-0516 7 2 55-61
Boerma D et al. Impaired quality of life 5 years after bile duct injury during laparoscopic cholecystectomy - A prospective analysis. (2001) ANNALS OF SURGERY 0003-4932 1528-1140 234 6 750-757
Bueno J et al. Colecistectomía laparoscópica y sus complicaciones: Nuestra experiencia en nueve años [Laparoscopic cholecystectomy and its complications: A 9-year experience]. (2001) CIRUGIA ESPANOLA 0009-739X 1578-147X 69 5 467-472
Mussack T et al. Zeitgerechtes Management von Gallengangkomplikationen nach laparoskopischer Cholecystektomie [Timely management of bile duct complications after laparoscopic cholecystectomy]. (2000) CHIRURG: ZEITSCHRIFT FUR ALLE GEBIETE DER OPERATIVEN MEDIZIN 0009-4722 1433-0385 71 2 174-181
Johnson S R et al. Long-term results of surgical repair of bile duct injuries following laparoscopic cholecystectomy. (2000) SURGERY 0039-6060 1532-7361 128 4 668-677
Feussner H et al. Iatrogenic lesions of the bile duct - an old problem. New aspects in the laparoscopic era. (2000) Megjelent: 8th International Congress of the European-Association-for-Endoscopic-Surgery pp. 25-29
Crema E et al. Hepatojejunal anastomosis in excluded loop through laparoscopy in the treatment of iatrogenic ligature of the bile duct. (1999) Megjelent: 3rd European Congress of the International Hepato-Pacreato-Biliary-Association pp. 31-36
Szeberin Z. Arteria hepatica communis aneurysma ruptura [Ruptured aneurysm of the common hepatic artery]. (2000) MAGYAR SEBÉSZET 0025-0295 1789-4301 53 2 70-72,
1622149
Rövid közlemény (Folyóiratcikk) | Tudományos[1622149]
Gottschalk U et al. Accidental cannulation of the hepatic artery following needle-knife sphincterotomy [Akzidentelle sondierung der A. hepatica im rahmen der madelmessersphincterotomie]. (2007) ZEITSCHRIFT FÜR GASTROENTEROLOGIE 0044-2771 1439-7803 45 8 702-705
Rövid közlemény (Folyóiratcikk) | Tudományos[21452411] [Admin láttamozott]
Gottschalk U et al. Pseudoaneurysm of the left hepatic artery as a result of ERCP: [Pseudoaneurysma der arteria hepatica sinistra als komplikation einer ERCP mit sphinkterotomie]. (2006) ZEITSCHRIFT FÜR GASTROENTEROLOGIE 0044-2771 1439-7803 44 4 329-332
Rövid közlemény (Folyóiratcikk) | Tudományos[21452412] [Admin láttamozott]
Bíró G et al. Homograft beültetéssel végzett artériás rekonstrukciók. (2001) MAGYAR SEBÉSZET 0025-0295 1789-4301 54 6 Suppl. 63-67,
1814923
Szakcikk (Folyóiratcikk) | Tudományos[1814923]
Csébi Péter et al. Morphological evaluation of experimental autologous rectus fascia sheath vascular grafts used for arterial replacement in a dog model. (2014) ACTA VETERINARIA HUNGARICA 0236-6290 1588-2705 62 4 429-438
Csébi Péter et al. Hogyan reagál az autológ rectushüvelyből képzett érgraft vazoaktív anyagok hatására? [How does the autologous internal rectus fascia sheath vascular graft react upon different vasoactive substances? Experimental myographic examination in a dog model]. (2014) MAGYAR ÁLLATORVOSOK LAPJA 0025-004X 3003-9924 136 12 743-749
Csébi Péter et al. Experimental results of using autologous rectus fascia sheath for venous patch grafts in dogs. (2011) ACTA VETERINARIA HUNGARICA 0236-6290 1588-2705 59 3 373-384
Szeberin Z et al. Proximális radio-cephalikus autológ fisztulák szerepe a hemodialízis-kezelés biztosításában [Role of autologous antebrachial arteriovenous fistula for vascular access in hemodialysis]. (2006) MAGYAR SEBÉSZET 0025-0295 1789-4301 59 6 421-428,
1348179
Szakcikk (Folyóiratcikk) | Tudományos[1348179]
Hever T et al. Morphological, hemodynamical and hemorheological changes of mature artificial saphenous arterio-venous shunt in the rat model. (2010) MICROSURGERY 0738-1085 1098-2752 30 8 649-656
Szabó Gy et al. Kardiogén sokkal szövődött miokardiális infarktus primer PCI-t követő intraorticus ballonpumpa kezelése bilateralis arteria iliaca communis elzáródás miatt bal arteria axillaris felőli behelyezéssel.. (2007) CARDIOLOGIA HUNGARICA 0133-5596 1588-0230 37 4 276-278,
1260003
Rövid közlemény (Folyóiratcikk) | Tudományos[1260003]
Zima E. Cardiogen shock. (2009) ORVOSKÉPZÉS 0030-6037 84 4 304-307
Szabolcs Z et al. Egyszerű sebészi módszer az aorta ascendensben elhelyezkedő nagy, lebegő thrombus eltávolítására. (2007) ORVOSI HETILAP 0030-6002 1788-6120 148 8 363-366,
1622310
Szakcikk (Folyóiratcikk) | Tudományos[1622310]
Blehm A et al. Rescue operation after ascending thoracic endovascular aortic repair in a patient with thrombosis of the left main coronary ostium. (2013) EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY 1010-7940 1873-734X 44 1 178-179
Rövid közlemény (Folyóiratcikk) | Tudományos[23443925] [Admin láttamozott]
Molnar AA et al. Generalized alterations in the biomechanical properties of large veins in non-thrombotic thrombophilic young patients. (2008) INTERNATIONAL ANGIOLOGY 0392-9590 1827-1839 27 3 247-252,
1245867
Szakcikk (Folyóiratcikk) | Tudományos[1245867]
Limper U. et al. The thrombotic risk of spaceflight: Has a serious problem been overlooked for more than half of a century?. (2021) EUROPEAN HEART JOURNAL 0195-668X 1522-9645 42 1 97-100
Paukovits TM et al. Transfemoral endovascular treatment of proximal common carotid artery lesions: a single-center experience on 153 lesions. (2008) JOURNAL OF VASCULAR SURGERY 0741-5214 1097-6809 48 1 80-87,
1321739
Szakcikk (Folyóiratcikk) | Tudományos[1321739]
Norman A.V. et al. Current Transthoracic Supra-Aortic Trunk Surgical Reconstruction Has Similar 30-Day Cardiovascular Outcomes Compared to Extra-Anatomic Revascularization but With Higher Morbidity Burden. (2024) ANNALS OF VASCULAR SURGERY 0890-5096 1615-5947 100 155-164
Teramoto M. et al. Common Carotid Artery Stenosis Degree as a Predictor of Cardiovascular Disease in a General Population: The Suita Study. (2024) JOURNAL OF THE AMERICAN HEART ASSOCIATION 2047-9980 2047-9980 13 1
Abe D. et al. New Cerebral Embolic Protection System for Endovascular Revascularization of Stenosis at the Origin of the Right Common Carotid Artery: the Counterflow Technique. (2023) CLINICAL NEURORADIOLOGY 1869-1439 1869-1447 33 3 857-864
Mazurek A. et al. Clinical Outcomes of Second- versus First-Generation Carotid Stents: A Systematic Review and Meta-Analysis. (2022) JOURNAL OF CLINICAL MEDICINE 2077-0383 11 16
Sokszerzős vagy csoportos szerzőségű szakcikk (Folyóiratcikk) | Tudományos[33120167] [Admin láttamozott]
Nagata T. et al. Aorto-left common carotid artery bypass with off-pump coronary artery bypass. (2022) ASIAN CARDIOVASCULAR & THORACIC ANNALS 0218-4923 1816-5370 30 4 471-473
Vértes Miklós et al. The incidence and risk factors of stent fracture in patients treated for proximal common carotid artery stenosis. (2020) JOURNAL OF VASCULAR SURGERY 0741-5214 1097-6809 71 3 824-831.e1
Vértes Miklós et al. Middle and Distal Common Carotid Artery Stenting: Long-Term Patency Rates and Risk Factors for In-Stent Restenosis. (2020) CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY 0174-1551 1432-086X 43 8 1134-1142
Wang L.J. et al. Impact of Adding Carotid Endarterectomy to Supra-aortic Trunk Surgical Reconstruction. (2020) ANNALS OF VASCULAR SURGERY 0890-5096 1615-5947 69 27-33
Robertson V. et al. A Systematic Review of Procedural Outcomes in Patients With Proximal Common Carotid or Innominate Artery Disease With or Without Tandem Ipsilateral Internal Carotid Artery Disease. (2020) EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY 1078-5884 1532-2165 60 6 817-827
Zhang Xiaoqiang et al. A Meta-Analysis of Transfemoral Endovascular Treatment of Common Carotid Artery Lesions. (2019) WORLD NEUROSURGERY 1878-8750 1878-8769 123 89-94
Ito Hidemichi et al. A case of tandem stenoses at the proximal common and internal carotid arteries treated with transbrachial stenting: A case report. (2019) INTERVENTIONAL NEURORADIOLOGY 1591-0199 2385-2011 1123-9344 25 2 225-229
Illuminati Giulio et al. Results of subclavian to carotid artery bypass for occlusive disease of the common carotid artery: A retrospective cohort study. (2018) INTERNATIONAL JOURNAL OF SURGERY 1743-9191 1743-9159 53 111-116
Tang Xiaobin et al. The modified "no touch' technique in the antegrade endovascular approach for left common carotid artery ostial stenosis stenting. (2017) JOURNAL OF NEUROINTERVENTIONAL SURGERY 1759-8478 1759-8486 9 2 137-142