{ "labelLang" : "hun", "responseDate" : "2024-03-28 09:38", "content" : { "otype" : "Citation", "mtid" : 25565682, "status" : "APPROVED", "published" : true, "comment" : "Abstract\nNucleoside triphosphate diphosphohydrolase3 (NTPDase3) is membrane-bound ectoenzyme\nwhich hydrolyzes extracellular ATP, thus modulating the function of purinergic\nreceptors and the pattern of purinergic signaling. Here we analyzed the developmental\nexpression of NTPDase3 in female hypothalamus, cerebral cortex and hippocampal formation\nat different postnatal ages (PD7–PD90) by qRT-PCR and immunohistochemistry. In\nhypothalamus and hippocampus, a similar developmental profile was seen: NTPDase3 gene\nexpression was stable during postnatal development and increased in adults. In the cortex,\nupregulation of NTPDase3 mRNA expression was seen at PD15 and further increase was\nevidenced in adults. Immunohistochemical analysis at PD7 revealed faint neuronal NTPDase3\nlocalization, in dorsal hypothalamus. The immunoreactivity (ir) gradually increased in PD15\nand PD20, in clusters of cells in the lateral, ventral and dorsomedial hypothalamus.\nFurthermore, in PD20 animals, NTPDase3-ir was detected on short fibers in the posterior\nhypothalamic area, while in PD30 the fibers appeared progressively longer and markedly\nvaricose. In adults, the strongest NTPDase3-ir was observed in collections of cells in\ndorsomedial hypothalamic nucleus, dorsal and lateral hypothalamus and in several thalamic\nareas, whereas the varicose fibers traversed entire diencephalon, particularly \nparaventricular\nthalamic nucleus, ventromedial and dorsomedial hypothalamic nuclei, the arcuate nucleus and\nthe prefornical part of the lateral hypothalamus. The presumably ascending NTPDase3-ir\nfibers were first observed in PD20; their density and the varicose appearance increased \nuntil\nthe adulthood. Prominent enhancement of NTPDase3-ir in the hypothalamus coincides with\nage when animals acquire diurnal rhythms of sleeping and feeding, supporting the hypothesis\nthat this enzyme may be involved in regulation of homeostatic functions.", "unhandledTickets" : 0, "oldTimestamp" : "2017-11-09T15:02:30.000+0000", "deleted" : false, "oldId" : 15565682, "lastRefresh" : "2023-09-19T05:54:49.090+0000", "lastModified" : "2017-11-09T15:02:30.000+0000", "created" : "2016-04-14T14:46:33.000+0000", "lastDuplumOK" : "2020-05-27T11:34:06.345+0000", "lastDuplumSearch" : "2020-05-27T11:34:06.345+0000", "tempLockers" : [ { "otype" : "Admin", "mtid" : 10073918, "link" : "/api/admin/10073918", "label" : "Kovács Marcell (MTMT Közp., admin)", "familyName" : "Kovács", "givenName" : "Marcell", "published" : true, "snippet" : true } ], "tempLocked" : "2021-09-15T08:56:12.404+0000", "publication" : { "otype" : "JournalArticle", "mtid" : 1228647, "link" : "/api/publication/1228647", "label" : "Kiss David S et al. Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral and lateral hypothalamic area of female rats: morphological characterization and functional implications. 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