Idézéskapcsolat

Bjelobaba I et al. The cortical stab injury induces beading of fibers expressing ecto-nucleoside triphosphate diphosphohydrolase 3.. (2010) NEUROSCIENCE 0306-4522 1873-7544 170 1 107-116

Közlemény:
S Kiss David et al. Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral and lateral hypothalamic area of female rats: morphological characterization and functional implications. (2009) REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 1477-7827 7 p. 31
Idéző közlemény:
Bjelobaba I et al. The cortical stab injury induces beading of fibers expressing ecto-nucleoside triphosphate diphosphohydrolase 3.. (2010) NEUROSCIENCE 0306-4522 1873-7544 170 1 107-116
Független: Igen
Megjegyzés: Abstract
The ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3), an enzyme involved in 
degradation of extracellular adenosine triphosphate (ATP), is expressed on nerve fibers in 
different brain regions, including cortex. Here we studied the expression and role of this 
enzyme after unilateral cortical stab injury in rats. In cortical sections of control rats, 
NTPDase3 immunoreactivity was associated with two types of fibers: thin processes, occasionally 
with small mushroom-like protrusions and slightly thicker fibers with more pronounced and more 
frequent varicosities, whereas immunopositive neuronal perycaria were never observed. Although 
NTPDase3–positive thin processes and thicker fibers, by general appearance, size and shape, 
could be dendrites and axons, respectively, they were never immunopositive for microtubule 
associated protein-2 or neurofilament H subunit. Cortical stab injury induced rapid (within 4 
hours) focal varicose swelling that evolved over time to prominent beading of NTPDase3–positive 
fibers. The NTPDase3–positive fibers in all experimental groups also abundantly express 
NTPDase1, ecto-5′-nucleotidase and P2X2 receptor channels. Because the brain injury causes a 
massive ATP release, it is reasonable to conclude that purinoreceptors and ectonucleotidases 
play an important role in the process of neuritic beading.
2021-03-09 02:46