Idézéskapcsolat

Diaz-Munoz M et al. Purine Molecules as Hypnogenic Factors Role of Adenosine, ATP, and Caffeine. (2010) Central Nervous System Agents in Medicinal Chemistry(Formerly Current Medicinal 10 4 259-268

Közlemény:
S Kiss David et al. Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral and lateral hypothalamic area of female rats: morphological characterization and functional implications. (2009) REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 1477-7827 1477-7827 7 p. 31
Idéző közlemény:
Diaz-Munoz M et al. Purine Molecules as Hypnogenic Factors Role of Adenosine, ATP, and Caffeine. (2010) Central Nervous System Agents in Medicinal Chemistry(Formerly Current Medicinal 10 4 259-268
Független: Igen
Megjegyzés: Abstract
Purines are ubiquitous molecules with important roles in the regulation of metabolic networks 
and signal transduction events. In the central nervous system, adenosine and ATP modulate the 
sleep-wake cycle, acting as ligands of specific transmembrane receptors and as allosteric 
effectors of key intracellular enzymes for brain energy expenditure. Two types of adenosine 
receptors seem to be relevant to the sleep function, A1 and A2A. Caffeine, an antagonist of 
adenosine receptors, has been used as a tool in some of the studies reviewed in the present 
chapter. Possible changes in adenosine functioning due to the aging process have been observed 
in animal models and abnormalities in the adenosine system could also explain primary insomnia 
or the reduced amount of delta sleep and increased sensitivity to caffeine in some subjects with 
sleep deficits. Caffeine is a methylated-derivate of xanthine with profound effects on the onset 
and quality of sleep episodes. This purine acts principally as an antagonist of the A2A 
receptors. Adenosine and ATP in the nervous system are the bridge between metabolic activity, 
recovery function, and purinergic transmission that underlies the daily wake-sleep cycle in 
mammals. Modulators of purine actions have the potential to alleviate insomnia and other sleep 
disorders based on their physiopathological role during the sleep process.
2021-03-09 02:58