https://m2.mtmt.hu/ hun 2026-03-05 12:14 true true 1 8 10 1 8 DESC publishedYear false ASC firstAuthor true ASC mtid true JournalArticle 36394571 VALIDATED true Funding Agency and Grant Number: National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK082412]; National Institutes of Health (NIH) Funding text: This work was supported by the National Institutes of Health (NIH) grant R01 DK082412 to MST. 0 false 2026-02-12T15:41:03.241+0000 2026-02-07T15:34:55.887+0000 2025-10-22T09:59:49.665+0000 true 10020321 Kereszturi Éva /api/author/10020321 Author true 10020321 2026-01-01T23:45:52.572+0000 2025-12-22T10:08:14.976+0000 true 521 Szuper Admin /api/admin/521 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Berke, Gergo Minigenes enhance heterologous expression and prevent aberrant splicing of mouse Spink1 true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 15 1 28222 28222 11 2025 The digestive enzyme trypsin is an important driver of pancreatitis development and progression. Inhibition of intrapancreatic trypsin activity is an attractive yet so far unsuccessful approach for the treatment and prevention of pancreatitis. Gene therapy using adeno-associated viral vector containing the human serine protease inhibitor Kazal type 1 (SPINK1) gene has shown efficacy against murine pancreatitis in preclinical experiments. To advance this method to clinical testing, viral vectors with improved inhibitor expression are needed. In this study, we investigated the effect of minigenes with single introns on the expression of the mouse Spink1 gene. We found that minigenes markedly stimulated the expression of mouse Spink1 mRNA and SPINK1 protein in HEK 293T cells transfected with plasmids and in AR42J rat pancreatic acinar cells and isolated mouse pancreatic acini transduced with adenoviral vectors. The optimal intron size for expression enhancement was 100 nucleotides. We also demonstrated that mouse Spink1 mRNA expressed from a cDNA construct underwent spurious mRNA splicing and minigenes prevented this splicing defect. However, enhancement of mouse Spink1 expression by minigenes was unrelated to the rescue of aberrant mRNA splicing. The observations will facilitate the development of advanced viral vectors harboring mouse Spink1 for preclinical therapeutic studies in mouse models of pancreatitis. 2025 true true true false false GOLD 2026-02-12 false http://www.nature.com/srep/index.html 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 10 Q1 A nemzetközi false 10082342 false false false 2026-01-20T11:00:43.210+0000 1 5 0 2 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 128256617 /api/authorship/128256617 1 0.5 true false false Author 10082342 /api/author/10082342 Berke Gergő true true Berke Gergo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128256618 /api/authorship/128256618 2 0.5 false true false Sahin-Toth Miklos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 30045695 /api/publicationidentifier/30045695 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1038/s41598-025-13128-7 https://doi.org/10.1038/s41598-025-13128-7 false true PublicationIdentifier 30045696 /api/publicationidentifier/30045696 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001543149000011 https://www.webofscience.com/wos/woscc/full-record/001543149000011 false true PublicationIdentifier 30045701 /api/publicationidentifier/30045701 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105012450845 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105012450845 false true PublicationIdentifier 30045697 /api/publicationidentifier/30045697 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40753100 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40753100&dopt=Abstract false true Keyword 223 /api/keyword/223 true 223 true Keyword 453 /api/keyword/453 true 453 true Keyword 629 /api/keyword/629 true 629 true Keyword 14005 /api/keyword/14005 true 14005 true Keyword 1028330 /api/keyword/1028330 true 1028330 true Keyword 1028946 /api/keyword/1028946 true 1028946 true Keyword 1119486 /api/keyword/1119486 true 1119486 true Keyword 1775538 /api/keyword/1775538 true true Keyword 1962793 /api/keyword/1962793 true true MtaRating 519359 /api/mtarating/519359 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19359 true MtaRating 11551161 /api/mtarating/11551161 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 11736317 /api/sjrrating/11736317 23 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true Q1 FROM_LAST_YEAR true true /api/publication/36394571 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10082342"><a href="/gui2/?type=authors&mode=browse&sel=10082342" target="_blank">Berke Gergo (<span class="authorship-author-name">Berke Gergő</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sahin-Toth Miklos </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36394571" target="_blank">Minigenes enhance heterologous expression and prevent aberrant splicing of mouse Spink1</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">1</span> <span class="page"> Paper 28222. 11 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41598-025-13128-7" target="_blank" href="https://doi.org/10.1038/s41598-025-13128-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001543149000011" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001543149000011"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105012450845" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105012450845"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40753100" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40753100&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36394571&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36394571</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.02.07. 16:34 Berke Gergő (Molekuláris biológia) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK082412]; National Institutes of Health (NIH) Funding text: This work was supported by the National Institutes of Health (NIH) grant R01 DK082412 to MST.</pre> </div></div> JournalArticle 34921299 APPROVED true 0 false 2026-02-12T15:40:07.922+0000 2026-02-07T15:32:01.909+0000 2024-06-06T04:42:10.929+0000 true 521 Szuper Admin /api/admin/521 Admin true 2025-06-26T20:51:12.744+0000 2025-06-26T20:51:12.744+0000 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2025-01-02T12:02:19.636+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000249 Comment, Correction true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000249 Hozzászólás, helyreigazítás SubType 111 true 10000249 true 1 /api/category/1 Category true 1 Berke, Gergo Intron-mediated enhancement of SPINK1 expression for pancreatitis therapy true true /api/journal/1736 REVIEWED true false 1736 false 1736 true 0017-5749 1468-3288 Journal FOREIGN 74 1 e9 e9 2 2024 2024 true true false false false NONE 2026-02-12 false 3 0 3 2 0 3 3 3 3 3 3 2 2 2 1 0 3 2 3 2 0 3 3 false 10034087,10082342 false false false 2025-02-26T19:26:30.955+0000 2 6 0 2 0 false 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 117048509 /api/authorship/117048509 1 0.5 true false false Author 10082342 /api/author/10082342 Berke Gergő true true Berke Gergo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 117048510 /api/authorship/117048510 2 0.5 false true true Author 10034087 /api/author/10034087 Sahin-Tóth Miklós true 10034087 true Sahin-Toth Miklos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 26370215 /api/publicationidentifier/26370215 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1136/gutjnl-2024-332818 https://doi.org/10.1136/gutjnl-2024-332818 false true PublicationIdentifier 26370214 /api/publicationidentifier/26370214 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001224994900001 https://www.webofscience.com/wos/woscc/full-record/001224994900001 false true PublicationIdentifier 26608799 /api/publicationidentifier/26608799 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85193947383 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85193947383 false true PublicationIdentifier 26608800 /api/publicationidentifier/26608800 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38754955 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38754955&dopt=Abstract false true Classification 12215 /api/classification/12215 true true Keyword 2906 /api/keyword/2906 true 2906 true Keyword 4658 /api/keyword/4658 true 4658 true Keyword 14005 /api/keyword/14005 true 14005 true Keyword 1048728 /api/keyword/1048728 true 1048728 true Keyword 1502826 /api/keyword/1502826 true true /api/publication/34921299 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10082342"><a href="/gui2/?type=authors&mode=browse&sel=10082342" target="_blank">Berke Gergo (<span class="authorship-author-name">Berke Gergő</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; 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Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rygiel Agnieszka Magdalena </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rosendahl Jonas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chen Jian-Min </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Witt Heiko </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pankreász Betegségek Intézete; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/Interdiszciplináris Kutatásfejlesztési és Innovációs Kiválósági Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sahin-Tóth Miklós<sup>**</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058581"><a href="/gui2/?type=authors&mode=browse&sel=10058581" target="_blank">Hegyi Eszter ✉ (<span class="authorship-author-name">Hegyi Eszter</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Genetikai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35658325" target="_blank">Carboxyl ester lipase hybrid 1 (CEL-HYB1) haplotypes confer varying risk for chronic pancreatitis</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">1</span> <span class="page"> Paper 30965. 7 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-024-82077-4" target="_blank" href="https://doi.org/10.1038/s41598-024-82077-4"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001386136100038" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001386136100038"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="225132" target="_blank" href="http://real.mtak.hu/225132"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85213516558" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85213516558"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="39730750" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=39730750&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35658325&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35658325</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (FK 143444), (BO/00824/23/5), (BO/00648/21/5), (23-5-PTE-2167) Támogató: ÚNKP, (23-3-II-PTE-2125) Támogató: ÚNKP, (UNKP- 23-5-SZTE-706), (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium, HCEMM(739593) Támogató: Horizon 2020 </div> <div class="lastModified">Utolsó módosítás: 2026.01.30. 13:04 Vékony-Pap Lili (SZTE admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div> JournalArticle 35278931 VALIDATED true 0 false 2026-03-05T10:33:31.285+0000 2026-02-07T15:27:21.634+0000 2024-09-14T19:48:10.662+0000 true 521 Szuper Admin /api/admin/521 Admin true 2025-07-31T08:43:14.372+0000 2024-10-25T12:23:17.771+0000 true 10082735 Tóth-Lipták Péter /api/admin/10082735 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Stefanovics, Regina Novel chymotrypsin C (CTRC ) variants from real-world genetic testing of pediatric chronic pancreatitis cases true true /api/journal/36760 REVIEWED true false 36760 false 36760 true 1424-3903 1424-3911 Journal FOREIGN 24 5 690 697 690 8 2024 Funding 2041307 /api/funding/2041307 false true Funding 2041308 /api/funding/2041308 false true Funding 2041309 /api/funding/2041309 false true 2024 true true true false true false GREEN 2026-03-05 true http://real.mtak.hu/206450 5 0 5 3 1 5 5 5 2 5 5 3 3 3 2 0 5 3 5 3 0 19 19 Q1 false 10028877,10082342 false false false 2024-10-24T12:23:16.965+0000 I. sz. 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Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077626"><a href="/gui2/?type=authors&mode=browse&sel=10077626" target="_blank">Sandor Mate (<span class="authorship-author-name">Sándor Máté</span> <span class="authorAux-mtmt"> hasnyálmirigy</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Demcsak Alexandra </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082342"><a href="/gui2/?type=authors&mode=browse&sel=10082342" target="_blank">Berke Gergo (<span class="authorship-author-name">Berke Gergő</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028877"><a href="/gui2/?type=authors&mode=browse&sel=10028877" target="_blank">Németh Balázs Csaba (<span class="authorship-author-name">Németh Balázs</span> <span class="authorAux-mtmt"> gasztroenterológia, mikrobiológia, immunológia,...</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/<span title="Belgyógyászati Klinika">BK</span>/I. sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zhang Wenying </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Abu-El-Haija Maisam </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sahin-Toth Miklos ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;35278931" target="_blank">Novel chymotrypsin C (CTRC ) variants from real-world genetic testing of pediatric chronic pancreatitis cases</a></div> <div> <span class="journal-title">PANCREATOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1424-3903">1424-3903</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1424-3911">1424-3911</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">5</span> <span class="page"> pp 690-697 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.pan.2024.06.003" target="_blank" href="https://doi.org/10.1016/j.pan.2024.06.003"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001268754200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001268754200001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="206450" target="_blank" href="http://real.mtak.hu/206450"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85195654657" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85195654657"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38876922" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38876922&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="33204" target="_blank" href="http://publicatio.bibl.u-szeged.hu/33204"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Gastroenterology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Hepatology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 3 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;35278931&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 19 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 35278931</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="funder"> HCEMM(739593) Támogató: Horizon 2020, (BO/00648/21/5), (UNKP- 23-5-SZTE-706) </div> <div class="lastModified">Utolsó módosítás: 2026.02.07. 16:27 Berke Gergő (Molekuláris biológia) </div> </div></div> JournalArticle 34011872 VALIDATED true * Megosztott szerzőség 0 false 2026-03-05T10:47:29.927+0000 2025-06-17T13:26:04.211+0000 2023-06-12T14:07:21.730+0000 true 10082342 Berke Gergő /api/author/10082342 Author true 2026-02-19T14:35:56.858+0000 2023-09-02T14:14:29.251+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Berke, Gergő Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: Case-control studies and meta-analysis true true /api/journal/36760 REVIEWED true false 36760 false 36760 true 1424-3903 1424-3911 Journal FOREIGN 23 5 481 490 481 10 2023 Funding 2037740 /api/funding/2037740 false true Funding 2037741 /api/funding/2037741 false true Funding 2037742 /api/funding/2037742 false true true 2023 true true true false true false GOLD 2026-03-05 true https://doi.org/10.1016/j.pan.2023.05.013 6 0 6 1 3 6 6 6 6 6 6 1 1 1 5 0 6 1 6 1 0 19 19 Q1 false 10058581,10028877,10082342 false false false 2023-06-13T06:29:34.388+0000 I. sz. Belgyógyászati Klinika (SZTE / SZAOK / BK); Pankreász Betegségek Részlege (SE / AOK / K); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE) 7 35 4 10 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 108972951 /api/authorship/108972951 1 0.1 true false false Author 10082342 /api/author/10082342 Berke Gergő true true Berke Gergő true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108972952 /api/authorship/108972952 2 0.1 true false false Beer Sebastian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108972953 /api/authorship/108972953 3 0.1 false false false Author 10048360 /api/author/10048360 Gede Noémi true 10048360 true Gede Noémi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108972954 /api/authorship/108972954 4 0.1 false false false Author 10100962 /api/author/10100962 Csurka-Takáts Amanda true true Takáts Amanda true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108972955 /api/authorship/108972955 5 0.1 false false false Author 10057649 /api/author/10057649 Szentesi Andrea Ildikó true 10057649 true Szentesi Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108972956 /api/authorship/108972956 6 0.1 false false false Author 10002629 /api/author/10002629 Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108972957 /api/authorship/108972957 7 0.1 false false false Rosendahl Jonas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108972958 /api/authorship/108972958 8 0.1 false true false Sahin-Tóth Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108972959 /api/authorship/108972959 9 0.1 false true false Author 10028877 /api/author/10028877 Németh Balázs true 10028877 true Németh Balázs Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 108972960 /api/authorship/108972960 10 0.1 false true true Author 10058581 /api/author/10058581 Hegyi Eszter true 10058581 true Hegyi Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24024029 /api/publicationidentifier/24024029 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1016/j.pan.2023.05.013 https://doi.org/10.1016/j.pan.2023.05.013 false true PublicationIdentifier 24296348 /api/publicationidentifier/24296348 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS 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10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37321941 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37321941&dopt=Abstract false true PublicationIdentifier 24098556 /api/publicationidentifier/24098556 SwordSource 90 /api/publicationsource/90 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 27761 http://publicatio.bibl.u-szeged.hu/27761 false true Classification 12302 /api/classification/12302 true true Classification 12124 /api/classification/12124 true true Keyword 3375201 /api/keyword/3375201 true true SjrRating 11376593 /api/sjrrating/11376593 27 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1310 /api/classificationexternal/1310 true 1310 true Q1 DIRECT true true /api/publication/34011872 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10082342"><a href="/gui2/?type=authors&mode=browse&sel=10082342" target="_blank">Berke Gergő (<span class="authorship-author-name">Berke Gergő</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Beer Sebastian<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048360"><a href="/gui2/?type=authors&mode=browse&sel=10048360" target="_blank">Gede Noémi (<span class="authorship-author-name">Gede Noémi</span> <span class="authorAux-mtmt"> Egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10100962"><a href="/gui2/?type=authors&mode=browse&sel=10100962" target="_blank">Takáts Amanda (<span class="authorship-author-name">Csurka-Takáts Amanda</span> <span class="authorAux-mtmt"> Orvosi genetika</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057649"><a href="/gui2/?type=authors&mode=browse&sel=10057649" target="_blank">Szentesi Andrea (<span class="authorship-author-name">Szentesi Andrea Ildikó</span> <span class="authorAux-mtmt"> Pankreatológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Pankreász Betegségek Részlege</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rosendahl Jonas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sahin-Tóth Miklós<sup>**</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028877"><a href="/gui2/?type=authors&mode=browse&sel=10028877" target="_blank">Németh Balázs Csaba<sup>**</sup> (<span class="authorship-author-name">Németh Balázs</span> <span class="authorAux-mtmt"> gasztroenterológia, mikrobiológia, immunológia,...</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/<span title="Belgyógyászati Klinika">BK</span>/I. sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058581"><a href="/gui2/?type=authors&mode=browse&sel=10058581" target="_blank">Hegyi Eszter ✉ (<span class="authorship-author-name">Hegyi Eszter</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34011872" target="_blank">Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: Case-control studies and meta-analysis</a></div> <div> <span class="journal-title">PANCREATOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1424-3903">1424-3903</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1424-3911">1424-3911</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">5</span> <span class="page"> pp 481-490 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.pan.2023.05.013" target="_blank" href="https://doi.org/10.1016/j.pan.2023.05.013"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001046997000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001046997000001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="206448" target="_blank" href="http://real.mtak.hu/206448"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85162101531" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85162101531"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37321941" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37321941&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="27761" target="_blank" href="http://publicatio.bibl.u-szeged.hu/27761"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Gastroenterology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Hepatology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 1 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt:&nbsp;6 | WoS/Scopus jelölt:&nbsp;6 | DOI jelölt:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34011872&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 19 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34011872</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (ÚNKP-22-5-SZTE-58), (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium, (BO/00648/21/5) </div> <div class="lastModified">Utolsó módosítás: 2025.06.17. 15:26 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div> JournalArticle 33193011 VALIDATED true * Megosztott szerzőség 0 false 2026-02-12T15:40:32.822+0000 2024-05-08T13:33:21.219+0000 2022-10-26T11:47:22.279+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2025-07-31T08:38:48.704+0000 2023-09-02T14:03:49.795+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2025-01-02T12:02:19.636+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Berke, Gergő Bicarbonate defective CFTR variants increase risk for chronic pancreatitis: A meta-analysis true true /api/journal/10007440 REVIEWED true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 17 10 e0276397 e0276397 11 2022 Cystic fibrosis transmembrane conductance regulator (CFTR) plays a central role in pancreatic ductal fluid secretion by mediating Cl- and HCO3- ion transport across the apical membrane. Severe CFTR mutations that diminish chloride conductance cause cystic fibrosis (CF) if both alleles are affected, whereas heterozygous carrier status increases risk for chronic pancreatitis (CP). It has been proposed that a subset of CFTR variants characterized by a selective bicarbonate conductance defect (CFTRBD) may be associated with CP but not CF. However, a rigorous genetic analysis of the presumed association has been lacking.To investigate the role of heterozygous CFTRBD variants in CP by meta-analysis of published case-control studies.A systematic search was conducted in the MEDLINE, Embase, Scopus, and CENTRAL databases for published studies that reported the CFTRBD variants p.R74Q, p.R75Q, p.R117H, p.R170H, p.L967S, p.L997F, p.D1152H, p.S1235R, and p.D1270N in CP patients and controls.Twenty-two studies were eligible for quantitative synthesis. Combined analysis of the 9 CFTRBD variants indicated enrichment in CP patients versus controls (OR = 2.31, 95% CI = 1.17-4.56). Individual analysis of CFTRBD variants revealed no association of p.R75Q with CP (OR = 1.12, 95% CI = 0.89-1.40), whereas variants p.R117H and p.L967S were significantly overrepresented in cases relative to controls (OR = 3.16, 95% CI = 1.94-5.14, and OR = 3.88, 95% CI = 1.32-11.47, respectively). The remaining 6 low-frequency variants gave inconclusive results when analyzed individually, however, their pooled analysis indicated association with CP (OR = 2.08, 95% CI = 1.38-3.13).Heterozygous CFTRBD variants, with the exception of p.R75Q, increase CP risk about 2-4-fold. 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Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048360"><a href="/gui2/?type=authors&mode=browse&sel=10048360" target="_blank">Gede Noémi (<span class="authorship-author-name">Gede Noémi</span> <span class="authorAux-mtmt"> Egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074633"><a href="/gui2/?type=authors&mode=browse&sel=10074633" target="_blank">Szadai Letícia (<span class="authorship-author-name">Szadai Leticia</span> <span class="authorAux-mtmt"> bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Bőrgyógyászati és Allergológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074191"><a href="/gui2/?type=authors&mode=browse&sel=10074191" target="_blank">Ocskay Klementina (<span class="authorship-author-name">Ocskay Klementina</span> <span class="authorAux-mtmt"> Pankreatológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Pankreász Betegségek Részlege</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034087"><a href="/gui2/?type=authors&mode=browse&sel=10034087" target="_blank">Sahin-Tóth Miklós<sup>**</sup> (<span class="authorship-author-name">Sahin-Tóth Miklós</span> <span class="authorAux-mtmt"> elméleti orvostudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058581"><a href="/gui2/?type=authors&mode=browse&sel=10058581" target="_blank">Hegyi Eszter ✉ (<span class="authorship-author-name">Hegyi Eszter</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;33193011" target="_blank">Bicarbonate defective CFTR variants increase risk for chronic pancreatitis: A meta-analysis</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">10</span> <span class="page"> Paper e0276397. 11 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0276397" target="_blank" href="https://doi.org/10.1371/journal.pone.0276397"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000925064400077" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000925064400077"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85140283685" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85140283685"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="36264955" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=36264955&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="26526" target="_blank" href="http://publicatio.bibl.u-szeged.hu/26526"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság II. FTO PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 9</span> | Független: 8 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt:&nbsp;9 | WoS/Scopus jelölt:&nbsp;9 | DOI jelölt:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;33193011&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 33193011</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (ÚNKP-21-3-I-PTE-1081), (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium, (460051) </div> <div class="lastModified">Utolsó módosítás: 2024.05.08. 15:33 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.01.02. 13:02 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div> JournalArticle 32837109 VALIDATED true * Megosztott szerzőség 0 false 2026-02-12T15:41:02.811+0000 2025-06-17T13:24:38.722+0000 2022-05-23T06:47:32.960+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2025-07-31T08:13:14.534+0000 2023-09-02T13:57:26.016+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2025-01-02T12:02:19.636+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Takáts, Amanda Risk of chronic pancreatitis in carriers of loss-of-function CTRC variants : A meta-analysis true true /api/journal/10007440 REVIEWED true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 17 5 e0268859 e0268859 14 2022 The digestive protease chymotrypsin C (CTRC) protects the pancreas against pancreatitis by degrading potentially harmful trypsinogen. Loss-of-function genetic variants in CTRC increase risk for chronic pancreatitis (CP) with variable effect size, as judged by the reported odds ratio (OR) values. Here, we performed a meta-analysis of published studies on four variants that alter the CTRC amino-acid sequence, are clinically relatively common (global carrier frequency in CP >1%), reproducibly showed association with CP and their loss of function phenotype was verified experimentally. We found strong enrichment of CTRC variants p.A73T, p.V235I, p.K247_R254del, and p.R245W in CP cases versus controls, yielding OR values of 6.5 (95% confidence interval (CI) 2.4-17.8), 4.5 (CI 2.2-9.1), 5.4 (CI 2.6-11.0), and 2.6 (CI 1.6-4.2), respectively. Subgroup analysis demonstrated disease association of variants p.K247_R254del and p.R245W in alcoholic CP with similar effect sizes as seen in the overall CP group. Homozygosity or compound heterozygosity were rare and seemed to be associated with higher risk. We also identified a so far unreported linkage disequilibrium between variant p.K247_R254del and the common c.180C>T (p.G60 =) haplotype. Taken together, the results indicate that heterozygous loss-of-function CTRC variants increase the risk for CP approximately 3-7-fold. This meta-analysis confirms the clinical significance of CTRC variants and provides further justification for the genetic screening of CP patients. Funding 2014760 /api/funding/2014760 false true Funding 2014761 /api/funding/2014761 false true Funding 2014762 /api/funding/2014762 false true Funding 2014763 /api/funding/2014763 false true Funding 2014764 /api/funding/2014764 false true Funding 2014765 /api/funding/2014765 false true true true 2022 true true true false true false GOLD 2026-02-12 true https://doi.org/10.1371/journal.pone.0268859 10 0 10 3 5 10 10 10 10 10 10 3 3 3 7 0 10 3 10 3 0 7 7 Q1 A false 10028877,10082342 false false false 2022-05-22T07:38:48.136+0000 I. sz. Belgyógyászati Klinika (SZTE / SZAOK / BK); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE) 7 36 3 10 0 true 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 101795427 /api/authorship/101795427 1 0.1 true false false Author 10100962 /api/author/10100962 Csurka-Takáts Amanda true true Takáts Amanda true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101795428 /api/authorship/101795428 2 0.1 true false false Author 10082342 /api/author/10082342 Berke Gergő true true Berke Gergő true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101795429 /api/authorship/101795429 3 0.1 false false false Author 10048360 /api/author/10048360 Gede Noémi true 10048360 true Gede Noémi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101795430 /api/authorship/101795430 4 0.1 false false false Author 10028877 /api/author/10028877 Németh Balázs true 10028877 true Németh Balázs Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101795431 /api/authorship/101795431 5 0.1 false false false Witt Heiko true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101795432 /api/authorship/101795432 6 0.1 false false false Głuszek Stanisław true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101795433 /api/authorship/101795433 7 0.1 false false false Rygiel Agnieszka Magdalena true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101795434 /api/authorship/101795434 8 0.1 false false false Author 10002629 /api/author/10002629 Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101795435 /api/authorship/101795435 9 0.1 false false false Author 10034087 /api/author/10034087 Sahin-Tóth Miklós true 10034087 true Sahin-Tóth Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 101795436 /api/authorship/101795436 10 0.1 false true true Author 10058581 /api/author/10058581 Hegyi Eszter true 10058581 true Hegyi Eszter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 21020954 /api/publicationidentifier/21020954 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1371/journal.pone.0268859 https://doi.org/10.1371/journal.pone.0268859 false true PublicationIdentifier 24304414 /api/publicationidentifier/24304414 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS 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19076 true MtaRating 11551131 /api/mtarating/11551131 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 11272470 /api/sjrrating/11272470 17 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true Q1 DIRECT true true /api/publication/32837109 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10100962"><a href="/gui2/?type=authors&mode=browse&sel=10100962" target="_blank">Takáts Amanda (<span class="authorship-author-name">Csurka-Takáts Amanda</span> <span class="authorAux-mtmt"> Orvosi genetika</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082342"><a href="/gui2/?type=authors&mode=browse&sel=10082342" target="_blank">Berke Gergő<sup>*</sup> (<span class="authorship-author-name">Berke Gergő</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048360"><a href="/gui2/?type=authors&mode=browse&sel=10048360" target="_blank">Gede Noémi (<span class="authorship-author-name">Gede Noémi</span> <span class="authorAux-mtmt"> Egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028877"><a href="/gui2/?type=authors&mode=browse&sel=10028877" target="_blank">Németh Balázs Csaba (<span class="authorship-author-name">Németh Balázs</span> <span class="authorAux-mtmt"> gasztroenterológia, mikrobiológia, immunológia,...</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/<span title="Belgyógyászati Klinika">BK</span>/I. sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Witt Heiko </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Głuszek Stanisław </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rygiel Agnieszka Magdalena </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/<span title="Belgyógyászati Klinika">BK</span>/I. sz. Belgyógyászati Klinika; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034087"><a href="/gui2/?type=authors&mode=browse&sel=10034087" target="_blank">Sahin-Tóth Miklós (<span class="authorship-author-name">Sahin-Tóth Miklós</span> <span class="authorAux-mtmt"> elméleti orvostudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058581"><a href="/gui2/?type=authors&mode=browse&sel=10058581" target="_blank">Hegyi Eszter ✉ (<span class="authorship-author-name">Hegyi Eszter</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32837109" target="_blank">Risk of chronic pancreatitis in carriers of loss-of-function CTRC variants : A meta-analysis</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">5</span> <span class="page"> Paper e0268859. 14 p. </span> <span class="year">(2022)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0268859" target="_blank" href="https://doi.org/10.1371/journal.pone.0268859"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001044846900040" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001044846900040"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85130446309" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85130446309"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="35594281" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35594281&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="24658" target="_blank" href="http://publicatio.bibl.u-szeged.hu/24658"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság II. FTO PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 3 | Függő: 7 | Nem jelölt: 0 | WoS jelölt: 10 | Scopus jelölt:&nbsp;10 | WoS/Scopus jelölt:&nbsp;10 | DOI jelölt:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32837109&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32837109</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (460051), (ÚNKP-21-3-I-PTE-1081), (K131996), (FK124632), GINOP 2.3.2-15- 2016-00048, EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2025.06.17. 15:24 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.01.02. 13:02 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div> JournalArticle 32166953 VALIDATED true * Megosztott szerzőség 0 false 2026-03-02T14:42:04.549+0000 2025-06-17T13:23:20.631+0000 2021-08-31T07:41:58.347+0000 true 10012589 Nemes Attila /api/author/10012589 Author true 10012589 2025-07-31T08:40:33.007+0000 2023-09-02T13:40:16.290+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2025-01-02T12:02:19.636+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Takáts, Amanda Common calcium-sensing receptor (CASR) gene variants do not modify risk for chronic pancreatitis in a Hungarian cohort true true /api/journal/36760 REVIEWED true false 36760 false 36760 true 1424-3903 1424-3911 Journal FOREIGN 21 7 1305 1310 1305 6 2021 Funding 2002968 /api/funding/2002968 false true Funding 2002969 /api/funding/2002969 false true Funding 2007135 /api/funding/2007135 false true Funding 2007136 /api/funding/2007136 false true Funding 2007137 /api/funding/2007137 false true true true 2021 true true true false true false GREEN 2026-03-02 true http://publicatio.bibl.u-szeged.hu/22235 7 0 7 6 1 7 6 5 7 7 7 6 6 6 1 0 7 6 7 6 0 10 10 Q1 false 10058581,10082342 false false false 2021-11-18T14:48:41.469+0000 Belgyógyászat,Gasztroenterológia, Hepatológia (FVSZGYEOK); I. sz. 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Classification 12124 /api/classification/12124 true true SjrRating 11228787 /api/sjrrating/11228787 56 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2712 /api/classificationexternal/2712 true 2712 true Q1 DIRECT true true /api/publication/32166953 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10100962"><a href="/gui2/?type=authors&mode=browse&sel=10100962" target="_blank">Takáts Amanda (<span class="authorship-author-name">Csurka-Takáts Amanda</span> <span class="authorAux-mtmt"> Orvosi genetika</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082342"><a href="/gui2/?type=authors&mode=browse&sel=10082342" target="_blank">Berke Gergő (<span class="authorship-author-name">Berke Gergő</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057649"><a href="/gui2/?type=authors&mode=browse&sel=10057649" target="_blank">Szentesi Andrea (<span class="authorship-author-name">Szentesi Andrea Ildikó</span> <span class="authorAux-mtmt"> Pankreatológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Klinika">BK</span>/I. sz. Belgyógyászati Klinika; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028653"><a href="/gui2/?type=authors&mode=browse&sel=10028653" target="_blank">Farkas Gyula (<span class="authorship-author-name">Farkas Gyula Jr.</span> <span class="authorAux-mtmt"> sebészet</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Sebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018183"><a href="/gui2/?type=authors&mode=browse&sel=10018183" target="_blank">Izbéki Ferenc (<span class="authorship-author-name">Izbéki Ferenc</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Fejér Megyei Szent György Egyetemi Oktató Kórház">FMSZGYEOK</span>/Belgyógyászat,Gasztroenterológia, Hepatológia</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064235"><a href="/gui2/?type=authors&mode=browse&sel=10064235" target="_blank">Erőss Bálint (<span class="authorship-author-name">Erőss Bálint Mihály</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000322"><a href="/gui2/?type=authors&mode=browse&sel=10000322" target="_blank">Czakó László (<span class="authorship-author-name">Czakó László</span> <span class="authorAux-mtmt"> gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Klinika">BK</span>/I. sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016651"><a href="/gui2/?type=authors&mode=browse&sel=10016651" target="_blank">Vincze Áron (<span class="authorship-author-name">Vincze Áron</span> <span class="authorAux-mtmt"> Klinikai gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/I. sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter<sup>**</sup> (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Klinika">BK</span>/I. sz. Belgyógyászati Klinika; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034087"><a href="/gui2/?type=authors&mode=browse&sel=10034087" target="_blank">Sahin-Tóth Miklós<sup>**</sup> (<span class="authorship-author-name">Sahin-Tóth Miklós</span> <span class="authorAux-mtmt"> elméleti orvostudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058581"><a href="/gui2/?type=authors&mode=browse&sel=10058581" target="_blank">Hegyi Eszter ✉ (<span class="authorship-author-name">Hegyi Eszter</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;32166953" target="_blank">Common calcium-sensing receptor (CASR) gene variants do not modify risk for chronic pancreatitis in a Hungarian cohort</a></div> <div> <span class="journal-title">PANCREATOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1424-3903">1424-3903</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1424-3911">1424-3911</a>)</span>: <span class="journal-volume">21</span> <span class="journal-issue">7</span> <span class="page"> pp 1305-1310 </span> <span class="year">(2021)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.pan.2021.08.012" target="_blank" href="https://doi.org/10.1016/j.pan.2021.08.012"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000729823500010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000729823500010"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85114231523" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85114231523"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34481716" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34481716&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="22235" target="_blank" href="http://publicatio.bibl.u-szeged.hu/22235"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Gastroenterology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Hepatology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 7</span> | Független: 6 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;7 | DOI jelölt:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;32166953&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 32166953</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Támogató: NKFIH, GINOP - STAY ALIVE(GINOP-2.3.2-15-2016-00048) Támogató: Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal, (460051), (R01 DK05808), (K131996) </div> <div class="lastModified">Utolsó módosítás: 2025.06.17. 15:23 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.01.02. 13:02 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>