https://m2.mtmt.hu/ hun 2026-06-13 01:38 true true 1 2 10 1 2 DESC publishedYear false ASC firstAuthor true ASC mtid true JournalArticle 31009490 VALIDATED true Cited By :16 Export Date: 20 September 2022 0 false 2026-06-11T13:58:09.200+0000 2025-03-28T12:51:24.765+0000 2019-12-16T10:01:40.842+0000 true 10000223 Hamar Péter /api/author/10000223 Author true 10000223 5483386 2026-06-11T13:19:29.377+0000 2026-06-11T13:55:23.875+0000 Admin 10069305 /api/admin/10069305 Kondor Zóra true true DUPLUM 2026-06-11T13:55:23.875+0000 2025-03-28T12:51:25.227+0000 true 10097129 Vékony-Pap Lili /api/admin/10097129 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szűcs, Gergő Prediabetes Induced by Fructose-Enriched Diet Influences Cardiac Lipidome and Proteome and Leads to Deterioration of Cardiac Function prior to the Development of Excessive Oxidative Stress and Cell Damage true true /api/journal/10011773 REVIEWED true false 10011773 false 10011773 true 1942-0900 1942-0994 Journal FOREIGN 2019 3218275 3218275 21 2019 Prediabetes is a condition affecting more than 35% of the population. In some forms, excessive carbohydrate intake (primarily refined sugar) plays a prominent role. Prediabetes is a symptomless, mostly unrecognized disease which increases cardiovascular risk. In our work, we examined the effect of a fructose-enriched diet on cardiac function and lipidome as well as proteome of cardiac muscle. Male Wistar rats were divided into two groups. The control group received a normal diet while the fructose-fed group received 60% fructose-supplemented chow for 24 weeks. Fasting blood glucose measurement and oral glucose tolerance test (OGTT) showed slightly but significantly elevated values due to fructose feeding indicating development of a prediabetic condition. Both echocardiography and isolated working heart perfusion performed at the end of the feeding protocol demonstrated diastolic cardiac dysfunction in the fructose-fed group. Mass spectrometry-based, high-performance lipidomic and proteomic analyses were executed from cardiac tissue. The lipidomic analysis revealed complex rearrangement of the whole lipidome with special emphasis on defects in cardiolipin remodeling. The proteomic analysis showed significant changes in 75 cardiac proteins due to fructose feeding including mitochondria-, apoptosis-, and oxidative stress-related proteins. Nevertheless, just very weak or no signs of apoptosis induction and oxidative stress were detected in the hearts of fructose-fed rats. Our results suggest that fructose feeding induces marked alterations in the cardiac lipidome, especially in cardiolipin remodeling, which leads to mitochondrial dysfunction and impaired cardiac function. However, at the same time, several adaptive responses are induced at the proteome level in order to maintain a homeostatic balance. These findings demonstrate that even very early stages of prediabetes can impair cardiac function and can result in significant changes in the lipidome and proteome of the heart prior to the development of excessive oxidative stress and cell damage. Funding 1987271 /api/funding/1987271 false true true true 2019 true true true false true false GOLD 2026-06-11 true https://doi.org/10.1155/2019/3218275 41 1 37 29 11 38 39 39 29 40 37 31 29 32 9 0 41 32 37 29 0 19 19 Q1 false 10008620,10027528,10025206,10055941,10029238,10027486 false false false 2020-01-20T14:58:16.147+0000 Biokémiai Intézet (HRN SZBK); Biokémiai Intézet (SZTE / SZAOK); Laboratóriumi Medicina Intézet (SZTE / SZAOK); Orvosi Vegytani Intézet (SZTE / SZAOK) 12 38 4 12 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 89544810 /api/authorship/89544810 1 0.083333336 true false true Author 10027528 /api/author/10027528 Szűcs Gergő true 10027528 true Szűcs Gergő true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89544811 /api/authorship/89544811 2 0.083 true false false Author 10055941 /api/author/10055941 Apjok-Sója Andrea true 10055941 true Sója Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89544812 /api/authorship/89544812 3 0.083 true false false Author 10025206 /api/author/10025206 Péter Mária true 10025206 true Péter Mária true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89544813 /api/authorship/89544813 4 0.083333336 false false false Author 10028929 /api/author/10028929 Sárközy Márta true 10028929 true Sárközy Márta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89544814 /api/authorship/89544814 5 0.083333336 false false false Author 10055010 /api/author/10055010 Bruszel Bella true 10055010 true Bruszel Bella true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89544815 /api/authorship/89544815 6 0.083333336 false false false Author 10028747 /api/author/10028747 Siska Andrea true 10028747 true Siska Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89544816 /api/authorship/89544816 7 0.083333336 false false false Author 10029238 /api/author/10029238 Földesi Imre true 10029238 true Földesi Imre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89544817 /api/authorship/89544817 8 0.083333336 false false false Author 10027486 /api/author/10027486 Szabó Zoltán true 10027486 true Szabó Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89544818 /api/authorship/89544818 9 0.083333336 false false false Author 10008620 /api/author/10008620 Janáky Tamás true 10008620 true Janáky Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89544819 /api/authorship/89544819 10 0.083333336 false false false Author 1035720 /api/author/1035720 Vigh László true 1035720 true Vígh László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89544820 /api/authorship/89544820 11 0.083 false true false Author 10024899 /api/author/10024899 Balogh Gábor true 10024899 true Balogh Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 89544821 /api/authorship/89544821 12 0.083333336 false true true Author 10028282 /api/author/10028282 Csont Tamás Bálint true 10028282 true Csont Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 16294670 /api/publicationidentifier/16294670 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1155/2019/3218275 https://doi.org/10.1155/2019/3218275 false true PublicationIdentifier 16354358 /api/publicationidentifier/16354358 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000504219500002 https://www.webofscience.com/wos/woscc/full-record/000504219500002 false true PublicationIdentifier 17768048 /api/publicationidentifier/17768048 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true 114245 https://real.mtak.hu/114245 false true PublicationIdentifier 16537007 /api/publicationidentifier/16537007 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85077314070 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85077314070 false true PublicationIdentifier 16597993 /api/publicationidentifier/16597993 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 31885782 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31885782&dopt=Abstract false true PublicationIdentifier 16868984 /api/publicationidentifier/16868984 SwordSource 90 /api/publicationsource/90 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 18653 http://publicatio.bibl.u-szeged.hu/18653 false true Classification 12125 /api/classification/12125 true true Classification 10575 /api/classification/10575 true true Classification 12291 /api/classification/12291 true true Classification 12209 /api/classification/12209 true true Classification 12221 /api/classification/12221 true true SjrRating 10750659 /api/sjrrating/10750659 94 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1303 /api/classificationexternal/1303 true 1303 true Q1 DIRECT true true /api/publication/31009490 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10027528"><a href="/gui2/?type=authors&mode=browse&sel=10027528" target="_blank">Szűcs Gergő ✉ (<span class="authorship-author-name">Szűcs Gergő</span> <span class="authorAux-mtmt"> experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055941"><a href="/gui2/?type=authors&mode=browse&sel=10055941" target="_blank">Sója Andrea<sup>*</sup> (<span class="authorship-author-name">Apjok-Sója Andrea</span> <span class="authorAux-mtmt"> Metabolikus betegségek szívhatásai</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025206"><a href="/gui2/?type=authors&mode=browse&sel=10025206" target="_blank">Péter Mária<sup>*</sup> (<span class="authorship-author-name">Péter Mária</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028929"><a href="/gui2/?type=authors&mode=browse&sel=10028929" target="_blank">Sárközy Márta (<span class="authorship-author-name">Sárközy Márta</span> <span class="authorAux-mtmt"> Elméleti orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055010"><a href="/gui2/?type=authors&mode=browse&sel=10055010" target="_blank">Bruszel Bella (<span class="authorship-author-name">Bruszel Bella</span> <span class="authorAux-mtmt"> Analitikai kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028747"><a href="/gui2/?type=authors&mode=browse&sel=10028747" target="_blank">Siska Andrea (<span class="authorship-author-name">Siska Andrea</span> <span class="authorAux-mtmt"> klinikai kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Laboratóriumi Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029238"><a href="/gui2/?type=authors&mode=browse&sel=10029238" target="_blank">Földesi Imre (<span class="authorship-author-name">Földesi Imre</span> <span class="authorAux-mtmt"> belgyógyászat, endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Laboratóriumi Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027486"><a href="/gui2/?type=authors&mode=browse&sel=10027486" target="_blank">Szabó Zoltán (<span class="authorship-author-name">Szabó Zoltán</span> <span class="authorAux-mtmt"> proteomika</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008620"><a href="/gui2/?type=authors&mode=browse&sel=10008620" target="_blank">Janáky Tamás (<span class="authorship-author-name">Janáky Tamás</span> <span class="authorAux-mtmt"> Kémiai analitika</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Vegytani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1035720"><a href="/gui2/?type=authors&mode=browse&sel=1035720" target="_blank">Vígh László (<span class="authorship-author-name">Vigh László</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024899"><a href="/gui2/?type=authors&mode=browse&sel=10024899" target="_blank">Balogh Gábor<sup>**</sup> (<span class="authorship-author-name">Balogh Gábor</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028282"><a href="/gui2/?type=authors&mode=browse&sel=10028282" target="_blank">Csont Tamás ✉ (<span class="authorship-author-name">Csont Tamás Bálint</span> <span class="authorAux-mtmt"> Kísérletes kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;31009490" target="_blank">Prediabetes Induced by Fructose-Enriched Diet Influences Cardiac Lipidome and Proteome and Leads to Deterioration of Cardiac Function prior to the Development of Excessive Oxidative Stress and Cell Damage</a></div> <div> <span class="journal-title">OXIDATIVE MEDICINE AND CELLULAR LONGEVITY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0900">1942-0900</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1942-0994">1942-0994</a>)</span>: <span class="journal-volume">2019</span> <span class="page"> Paper 3218275. 21 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1155/2019/3218275" target="_blank" href="https://doi.org/10.1155/2019/3218275"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000504219500002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000504219500002"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="114245" target="_blank" href="https://real.mtak.hu/114245"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85077314070" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85077314070"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31885782" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31885782&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="18653" target="_blank" href="http://publicatio.bibl.u-szeged.hu/18653"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 41</span> | Független: 32 | Függő: 9 | Nem jelölt: 0 | WoS jelölt: 39 | Scopus jelölt:&nbsp;29 | WoS/Scopus jelölt:&nbsp;40 | DOI jelölt:&nbsp;39 (Nem nyilvános:&nbsp;1) </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31009490&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 19 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31009490</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző Duplum | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Támogató: NKFIH </div> <div class="duplumMark">Duplumjelölés: 2026.06.11. 15:15 (Kondor Zóra (SE_KK_Admin5_KZ, admin)) </div> <div class="notDuplums"><a target="_blank" href="/api/publication/31009490/notduplums">1 Nem duplumnak jelölés</a> </div> <div class="lastModified">Utolsó módosítás: 2025.03.28. 13:51 Vékony-Pap Lili (SZTE admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :16 Export Date: 20 September 2022</pre> </div></div> JournalArticle 3100419 VALIDATED true University of Szeged, Department of Biochemistry, Faculty of Medicine, Dóm tér 9, Szeged, 6720, Hungary University of Szeged, Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, Szeged, Hungary Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary Pharmahungary Group, Szeged, Hungary Semmelweis University, Department of Pharmacology and Pharmacotherapy, Budapest, Hungary Cited By :18 Export Date: 9 October 2021 CODEN: CDAIA Correspondence Address: Csont, T.; University of Szeged, Dóm tér 9, Hungary; email: csont.tamas@med.u-szeged.hu Chemicals/CAS: cholesterol, 57-88-5; glucose, 50-99-7, 84778-64-3; insulin, 9004-10-8; Blood Glucose 0 2018-08-27T17:47:05.000+0000 false 3100419 2026-06-11T13:25:32.790+0000 2026-06-11T13:18:32.711+0000 2016-08-15T06:04:19.000+0000 true 10010125 Ferdinandy Péter /api/author/10010125 Author true 10010125 2026-06-11T13:18:32.239+0000 2021-02-02T14:38:36.754+0000 true 10075782 Ferbert Barbara /api/admin/10075782 Admin true 2021-04-12T09:57:42.728+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sarkozy, M Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats true true /api/journal/10011378 REVIEWED true false 10011378 false 10011378 true 1475-2840 1475-2840 Journal FOREIGN 15 1 110 110 21 2016 BACKGROUND: There is a spectacular rise in the global prevalence of type 2 diabetes mellitus (T2DM) due to the worldwide obesity epidemic. However, a significant proportion of T2DM patients are non-obese and they also have an increased risk of cardiovascular diseases. As the Goto-Kakizaki (GK) rat is a well-known model of non-obese T2DM, the goal of this study was to investigate the effect of non-obese T2DM on cardiac alterations of the transcriptome in GK rats. METHODS: Fasting blood glucose, serum insulin and cholesterol levels were measured at 7, 11, and 15 weeks of age in male GK and control rats. Oral glucose tolerance test and pancreatic insulin level measurements were performed at 11 weeks of age. At week 15, total RNA was isolated from the myocardium and assayed by rat oligonucleotide microarray for 41,012 genes, and then expression of selected genes was confirmed by qRT-PCR. Gene ontology and protein-protein network analyses were performed to demonstrate potentially characteristic gene alterations and key genes in non-obese T2DM. RESULTS: Fasting blood glucose, serum insulin and cholesterol levels were significantly increased, glucose tolerance and insulin sensitivity were significantly impaired in GK rats as compared to controls. In hearts of GK rats, 204 genes showed significant up-regulation and 303 genes showed down-regulation as compared to controls according to microarray analysis. Genes with significantly altered expression in the heart due to non-obese T2DM includes functional clusters of metabolism (e.g. Cyp2e1, Akr1b10), signal transduction (e.g. Dpp4, Stat3), receptors and ion channels (e.g. Sln, Chrng), membrane and structural proteins (e.g. Tnni1, Mylk2, Col8a1, Adam33), cell growth and differentiation (e.g. Gpc3, Jund), immune response (e.g. C3, C4a), and others (e.g. Lrp8, Msln, Klkc1, Epn3). Gene ontology analysis revealed several significantly enriched functional inter-relationships between genes influenced by non-obese T2DM. Protein-protein interaction analysis demonstrated that Stat is a potential key gene influenced by non-obese T2DM. CONCLUSIONS: Non-obese T2DM alters cardiac gene expression profile. The altered genes may be involved in the development of cardiac pathologies and could be potential therapeutic targets in non-obese T2DM. true 2016 948716 true true true false true false GOLD 2026-06-11 true https://doi.org/10.1186/s12933-016-0424-3 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 32 0 30 24 6 30 29 28 28 28 28 22 22 26 6 0 32 26 30 24 0 12 12 Q1 false 10055941,10034993 false false false 2016-10-06T12:35:24.000+0000 2016-08-15T06:23:36.000+0000 Biokémiai Intézet (SZTE / SZAOK); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Élettani, Szervezettani és Idegtudományi Tanszék (SZTE / TTIK / BI) 9 25 3 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 8171897 /api/authorship/8171897 1 0.09090909 true false Author 10028929 /api/author/10028929 Sárközy Márta true 10028929 true Sarkozy M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24677752 true PersonAuthorship 8171898 /api/authorship/8171898 2 0.091 false false Author 10027528 /api/author/10027528 Szűcs Gergő true 10027528 true Szucs G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24677751 true PersonAuthorship 8171899 /api/authorship/8171899 3 0.09090909 false false Fekete V true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24677750 true PersonAuthorship 8171900 /api/authorship/8171900 4 0.09090909 false false Author 10034993 /api/author/10034993 Pipicz Márton true 10034993 true Pipicz M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24677749 true PersonAuthorship 8171901 /api/authorship/8171901 5 0.09090909 false false Eder K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24677748 true PersonAuthorship 8171902 /api/authorship/8171902 6 0.09090909 false false Author 10028933 /api/author/10028933 Molnár-Gáspár Renáta true 10028933 true Gaspar R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24677747 true PersonAuthorship 8171903 /api/authorship/8171903 7 0.09090909 false false Author 10055941 /api/author/10055941 Apjok-Sója Andrea true 10055941 true Soja A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24677746 true PersonAuthorship 8171904 /api/authorship/8171904 8 0.09090909 false false Author 10028761 /api/author/10028761 Pipis Judit true 10028761 true Pipis J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24677745 true PersonAuthorship 8171905 /api/authorship/8171905 9 0.09090909 false false Author 10010125 /api/author/10010125 Ferdinandy Péter true 10010125 true Ferdinandy P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24677744 true PersonAuthorship 8171906 /api/authorship/8171906 10 0.09090909 false false Author 10026464 /api/author/10026464 Csonka Csaba true 10026464 true Csonka C true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24677743 true PersonAuthorship 8171907 /api/authorship/8171907 11 0.091 false true true Author 10028282 /api/author/10028282 Csont Tamás Bálint true 10028282 true Csont T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 24677742 true PublicationIdentifier 1118977 /api/publicationidentifier/1118977 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1186/s12933-016-0424-3 https://doi.org/10.1186/s12933-016-0424-3 false 1410197 true PublicationIdentifier 1118979 /api/publicationidentifier/1118979 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true NO 41615 https://real.mtak.hu/41615 false 1466131 true PublicationIdentifier 1118980 /api/publicationidentifier/1118980 SwordSource 84 /api/publicationsource/84 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SE Repozitórium SE Repozitórium https://repo.lib.semmelweis.hu/handle/123456789/@@@ true true 84 true GREEN true IDENTICAL 6184 https://repo.lib.semmelweis.hu/handle/123456789/6184 false 1817661 true PublicationIdentifier 1118975 /api/publicationidentifier/1118975 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000381194800003 https://www.webofscience.com/wos/woscc/full-record/000381194800003 false 1452725 true PublicationIdentifier 1118976 /api/publicationidentifier/1118976 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84982829075 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84982829075 false 1452724 true PublicationIdentifier 1118978 /api/publicationidentifier/1118978 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 27496100 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27496100&dopt=Abstract false 1410198 true PublicationIdentifier 1118982 /api/publicationidentifier/1118982 PlainSource 137 /api/publicationsource/137 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true Pubmed Central http://www.ncbi.nlm.nih.gov/pmc/articles/@@@ true true 137 true GOLD true IDENTICAL PMC4975916 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975916 false 1577163 true PublicationIdentifier 1118981 /api/publicationidentifier/1118981 SwordSource 90 /api/publicationsource/90 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 9719 http://publicatio.bibl.u-szeged.hu/9719 false 1466248 true Classification 12125 /api/classification/12125 true true Classification 10575 /api/classification/10575 true true Classification 12291 /api/classification/12291 true true Classification 12215 /api/classification/12215 true true Classification 12209 /api/classification/12209 true true SjrRating 10919140 /api/sjrrating/10919140 43 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 true 2705 true Q1 DIRECT true true /api/publication/3100419 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10028929"><a href="/gui2/?type=authors&mode=browse&sel=10028929" target="_blank">Sarkozy M (<span class="authorship-author-name">Sárközy Márta</span> <span class="authorAux-mtmt"> Elméleti orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027528"><a href="/gui2/?type=authors&mode=browse&sel=10027528" target="_blank">Szucs G (<span class="authorship-author-name">Szűcs Gergő</span> <span class="authorAux-mtmt"> experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Biológia Intézet">BI</span>/Élettani, Szervezettani és Idegtudományi Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fekete V </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034993"><a href="/gui2/?type=authors&mode=browse&sel=10034993" target="_blank">Pipicz M (<span class="authorship-author-name">Pipicz Márton</span> <span class="authorAux-mtmt"> experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Eder K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028933"><a href="/gui2/?type=authors&mode=browse&sel=10028933" target="_blank">Gaspar R (<span class="authorship-author-name">Molnár-Gáspár Renáta</span> <span class="authorAux-mtmt"> experimentális kardiológia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055941"><a href="/gui2/?type=authors&mode=browse&sel=10055941" target="_blank">Soja A (<span class="authorship-author-name">Apjok-Sója Andrea</span> <span class="authorAux-mtmt"> Metabolikus betegségek szívhatásai</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028761"><a href="/gui2/?type=authors&mode=browse&sel=10028761" target="_blank">Pipis J (<span class="authorship-author-name">Pipis Judit</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy P (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026464"><a href="/gui2/?type=authors&mode=browse&sel=10026464" target="_blank">Csonka C (<span class="authorship-author-name">Csonka Csaba</span> <span class="authorAux-mtmt"> experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028282"><a href="/gui2/?type=authors&mode=browse&sel=10028282" target="_blank">Csont T ✉ (<span class="authorship-author-name">Csont Tamás Bálint</span> <span class="authorAux-mtmt"> Kísérletes kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3100419" target="_blank">Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats</a></div> <div> <span class="journal-title">CARDIOVASCULAR DIABETOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1475-2840">1475-2840</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1475-2840">1475-2840</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">1</span> <span class="page"> Paper 110. 21 p. </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s12933-016-0424-3" target="_blank" href="https://doi.org/10.1186/s12933-016-0424-3"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="41615" target="_blank" href="https://real.mtak.hu/41615"> REAL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="6184" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/6184"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000381194800003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000381194800003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84982829075" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84982829075"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="27496100" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27496100&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="PMC4975916" target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975916"> Pubmed Central </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="9719" target="_blank" href="http://publicatio.bibl.u-szeged.hu/9719"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 32</span> | Független: 26 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 28 | Scopus jelölt:&nbsp;28 | WoS/Scopus jelölt:&nbsp;28 | DOI jelölt:&nbsp;29 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3100419&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3100419</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3100419</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2026.06.11. 15:18 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: University of Szeged, Department of Biochemistry, Faculty of Medicine, Dóm tér 9, Szeged, 6720, Hungary University of Szeged, Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, Szeged, Hungary Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary Pharm...</pre> </div></div>