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<span class="author-name" mtid="10040398"> <a href="/gui2/?type=authors&mode=browse&sel=10040398" target="_blank">Vodicska, Barbara</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Servois, Vincent </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;32078289" mtid="32078289" target="_blank">A computational method for prioritizing targeted therapies in precision oncology: performance analysis in the SHIVA01 trial</a></div> <div class="pub-info"> <span class="journal-title">NPJ PRECISION ONCOLOGY</span> <span class="journal-volume">5</span> : <span class="journal-issue">1</span> <span class="page"> Paper: 59 , 11 p. </span> <span class="year">(2021)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41698-021-00191-2" target="_blank" href="https://doi.org/10.1038/s41698-021-00191-2"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000668710700002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000668710700002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85113505667" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85113505667"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="34162980" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34162980&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:32078289 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 16</span> | Független: 11 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 15 | Scopus jelölt: 14 | WoS/Scopus jelölt: 16 | DOI jelölt: 15 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10040839"><a href="/gui2/?type=authors&mode=browse&sel=10040839" target="_blank">Petak Istvan ✉ (<span class="authorship-author-name">Peták István</span> <span class="authorAux-mtmt"> farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ; 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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10012168"> <a href="/gui2/?type=authors&mode=browse&sel=10012168" target="_blank">Urbán, László ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10012376"> <a href="/gui2/?type=authors&mode=browse&sel=10012376" target="_blank">Dóczi, Róbert<sup>*</sup></a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10040398"> <a href="/gui2/?type=authors&mode=browse&sel=10040398" target="_blank">Vodicska, Barbara</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Tihanyi, Dóra </span> <span class="author-type"> </span> ; <span class="author-name" > Horváth, Magdolna </span> <span class="author-type"> </span> ; <span class="author-name" > Kormos, Dóra </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10054903"> <a href="/gui2/?type=authors&mode=browse&sel=10054903" target="_blank">Takács, István</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Pápai-Székely, Zsolt </span> <span class="author-type"> </span> ; <span class="author-name" > Póka-Farkas, Zsuzsanna </span> <span class="author-type"> </span> ; <span class="author-name" > Várkondi, Edit </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;31816879" mtid="31816879" target="_blank">Major Clinical Response to Afatinib Monotherapy in Lung Adenocarcinoma Harboring EGFR Exon 20 Insertion Mutation</a></div> <div class="pub-info"> <span class="journal-title">CLINICAL LUNG CANCER</span> <span class="journal-volume">22</span> : <span class="journal-issue">1</span> <span class="page"> pp. e112-e115. </span> <span class="year">(2021)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1016/j.cllc.2020.09.005" target="_blank" href="https://doi.org/10.1016/j.cllc.2020.09.005"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000608186600024" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000608186600024"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85092903654" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85092903654"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33082101" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=33082101&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:31816879 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core">Forrás </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 8</span> | Független: 8 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt: 7 | WoS/Scopus jelölt: 8 | DOI jelölt: 8 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" mtid="10012168"><a
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<span class="authorAux-mtmt"> Immunológia, klinikai onkológia</span>)
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<span class="authorAux-mtmt"> Biológia tudományok</span>)
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<span class="authorAux-mtmt"> Hematológia, belgyógyászat, onkológia</span>)
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;
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;31816879" target="_blank">Major Clinical Response to Afatinib Monotherapy in Lung Adenocarcinoma Harboring EGFR Exon 20 Insertion Mutation</a></div> <div> <span class="journal-title">CLINICAL LUNG CANCER</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1525-7304">1525-7304</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1938-0690">1938-0690</a>)</span>:
<span class="journal-volume">22</span> <span class="journal-issue">1</span>
<span class="page">
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<span class="language" xmlns="http://www.w3.org/1999/html">Nyelv:
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| <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott
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<div class="lastModified">Utolsó módosítás: 2022.06.08. 16:03 Vándor Andrea (VA, admin)
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<div class="lockedBy">Ideiglenesen zárolva 2022.03.25. 10:34 Boros Annamária (MTMT Központi admin)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: L.U., R.D., C.H., I.V.-N., and I.P. contributed equally to this work as first authors
Case report!</pre>
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10012168"> <a href="/gui2/?type=authors&mode=browse&sel=10012168" target="_blank">Urbán, László ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10012376"> <a href="/gui2/?type=authors&mode=browse&sel=10012376" target="_blank">Dóczi, Róbert</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10040398"> <a href="/gui2/?type=authors&mode=browse&sel=10040398" target="_blank">Vodicska, Barbara</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Kormos, Dóra </span> <span class="author-type"> </span> ; <span class="author-name" > Tóth, László </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10054903"> <a href="/gui2/?type=authors&mode=browse&sel=10054903" target="_blank">Takács, István</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Várkondi, Edit </span> <span class="author-type"> </span> ; <span class="author-name" > Tihanyi, Dóra </span> <span class="author-type"> </span> ; <span class="author-name" > Lakatos, Dóra </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10089485"> <a href="/gui2/?type=authors&mode=browse&sel=10089485" target="_blank">Dirner, Anna</a> </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;31609199" mtid="31609199" target="_blank">Efficacy of Incremental Next-Generation ALK Inhibitor Treatment in Oncogene-Addicted, ALK-Positive, TP53-Mutant NSCLC</a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF PERSONALIZED MEDICINE</span> <span class="journal-volume">10</span> : <span class="journal-issue">3</span> <span class="page"> Paper: 107 , 7 p. </span> <span class="year">(2020)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/jpm10030107" target="_blank" href="https://doi.org/10.3390/jpm10030107"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000579785800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000579785800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85090534838" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85090534838"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32872120" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32872120&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:31609199 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core">Forrás </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 5 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt: 6 | WoS/Scopus jelölt: 6 | DOI jelölt: 6 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
<div class="authors">
<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
<div class="autype autype0"> <span class="author-name" mtid="10012168"><a
href="/gui2/?type=authors&mode=browse&sel=10012168" target="_blank">Urbán László ✉
(<span class="authorship-author-name">Urbán László</span>
<span class="authorAux-mtmt"> Immunológia, klinikai onkológia</span>)
</a>
</span>
;
<span class="author-name" mtid="10012376"><a
href="/gui2/?type=authors&mode=browse&sel=10012376" target="_blank">Dóczi Róbert
(<span class="authorship-author-name">Dóczi Róbert</span>
<span class="authorAux-mtmt"> Növényi molekuláris biológia</span>)
</a>
</span>
;
<span class="author-name" mtid="10040398"><a
href="/gui2/?type=authors&mode=browse&sel=10040398" target="_blank">Vodicska Barbara
(<span class="authorship-author-name">Vodicska Barbara</span>
<span class="authorAux-mtmt"> Biológia tudományok</span>)
</a>
</span>
;
<span class="author-name" >Kormos Dóra
</span>
;
<span class="author-name" >Tóth László
</span>
;
<span class="author-name" mtid="10054903"><a
href="/gui2/?type=authors&mode=browse&sel=10054903" target="_blank">Takács István
(<span class="authorship-author-name">Takács István</span>
<span class="authorAux-mtmt"> hematológia</span>)
</a>
</span>
<span class="author-affil"><span title="Miskolci Egyetem">ME</span>/<span title="Egészségügyi Kar">EK</span>/Alkalmazott Egészségtudományok Intézete</span>
;
<span class="author-name" >Várkondi Edit
</span>
;
<span class="author-name" >Tihanyi Dóra
</span>
;
<span class="author-name" >Lakatos Dóra
</span>
;
<span class="author-name" mtid="10089485"><a
href="/gui2/?type=authors&mode=browse&sel=10089485" target="_blank">Dirner Anna
(<span class="authorship-author-name">Dirner Anna</span>
<span class="authorAux-mtmt"> molekuláris onkológia</span>)
</a>
</span>
;
<span class="author-name" mtid="10034838"><a
href="/gui2/?type=authors&mode=browse&sel=10034838" target="_blank">Vályi-Nagy István
(<span class="authorship-author-name">Vályi-Nagy István</span>
<span class="authorAux-mtmt"> Hematológia, belgyógyászat, onkológia</span>)
</a>
</span>
;
<span class="author-name" mtid="10040839"><a
href="/gui2/?type=authors&mode=browse&sel=10040839" target="_blank">Peták István ✉
(<span class="authorship-author-name">Peták István</span>
<span class="authorAux-mtmt"> farmakológia</span>)
</a>
</span>
<span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;31609199" target="_blank">Efficacy of Incremental Next-Generation ALK Inhibitor Treatment in Oncogene-Addicted, ALK-Positive, TP53-Mutant NSCLC</a></div> <div> <span class="journal-title">JOURNAL OF PERSONALIZED MEDICINE</span>
<span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2075-4426">2075-4426</a>)</span>:
<span class="journal-volume">10</span> <span class="journal-issue">3</span>
<span class="page">
Paper 107.
7 p.
</span> <span class="year">(2020)</span>
</div>
<div class="pub-footer">
<span class="language" xmlns="http://www.w3.org/1999/html">Nyelv:
Angol
| </span>
<span class="identifiers">
<span class="id identifier oa_GOLD" title=" Gold
">
<a style="color:blue" title="10.3390/jpm10030107" target="_blank" href="https://doi.org/10.3390/jpm10030107">
DOI
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="000579785800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000579785800001">
WoS
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="85090534838" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85090534838">
Scopus
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="32872120" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32872120&dopt=Abstract">
PubMed
</a>
</span>
</span>
<div class="publication-citation" style="margin-left: 0.5cm;">
<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span>
| Független: 5
| Függő: 1
| Nem jelölt: 0
| WoS jelölt: 4
| Scopus jelölt: 6
| WoS/Scopus jelölt: 6
| DOI jelölt: 6
</div>
<div class="mtid"><span class="long-pub-mtid">Közlemény: 31609199</span>
| <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott
</span>
Forrás
| <span class="type-subtype">Folyóiratcikk
( Szakcikk
)
</span>
| <span class="pub-category">Tudományos</span>
| <span class="publication-sourceOfData">kézi felvitel</span>
</div>
<div class="lastModified">Utolsó módosítás: 2024.02.01. 16:42 Dirner Anna (molekuláris onkológia)
</div>
<div class="lockedBy">Ideiglenesen zárolva 2022.03.25. 10:34 Boros Annamária (MTMT Központi admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Case report!</pre>
</div></div>
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Several promising anti-cancer drug–GnRH (gonadotropin-releasing hormone) conjugates have been developed in the last two decades, although none of them have been approved for clinical use yet. Crizotinib is an effective multi-target kinase inhibitor, approved against anaplastic lymphoma kinase (ALK)- or ROS proto-oncogene 1 (ROS-1)-positive non-small cell lung carcinoma (NSCLC); however, its application is accompanied by serious side effects. In order to deliver crizotinib selectively into the tumor cells, we synthesized novel crizotinib analogues and conjugated them to a [d-Lys6]–GnRH-I targeting peptide. Our most prominent crizotinib–GnRH conjugates, the amide-bond-containing [d-Lys6(crizotinib*)]–GnRH-I and the ester-bond-containing [d-Lys6(MJ55*)]–GnRH-I, were able to bind to GnRH-receptor (GnRHR) and exert a potent c-Met kinase inhibitory effect. The efficacy of compounds was tested on the MET-amplified and GnRHR-expressing EBC-1 NSCLC cells. In vitro pharmacological profiling led to the conclusion that that crizotinib–GnRH conjugates are transported directly into lysosomes, where the membrane permeability of crizotinib is diminished. As a consequence of GnRHR-mediated endocytosis, GnRH-conjugated crizotinib bypasses its molecular targets—the ATP-binding site of RTKs— and is sequestered in the lysosomes. These results explained the lower efficacy of crizotinib–GnRH conjugates in EBC-1 cells, and led to the conclusion that drug escape from the lysosomes is a major challenge in the development of clinically relevant anti-cancer drug–GnRH conjugates.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10047778"> <a href="/gui2/?type=authors&mode=browse&sel=10047778" target="_blank">Murányi, József ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10040840"> <a href="/gui2/?type=authors&mode=browse&sel=10040840" target="_blank">Varga, Attila</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10028916"> <a href="/gui2/?type=authors&mode=browse&sel=10028916" target="_blank">Gyulavári, Pál</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10044963"> <a href="/gui2/?type=authors&mode=browse&sel=10044963" target="_blank">Pénzes, Kinga</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10054897"> <a href="/gui2/?type=authors&mode=browse&sel=10054897" target="_blank">Németh, Csilla E.</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000786"> <a href="/gui2/?type=authors&mode=browse&sel=10000786" target="_blank">Csala, Miklós</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10046429"> <a href="/gui2/?type=authors&mode=browse&sel=10046429" target="_blank">Pethő, Lilla</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10008627"> <a href="/gui2/?type=authors&mode=browse&sel=10008627" target="_blank">Csámpai, Antal</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10001938"> <a href="/gui2/?type=authors&mode=browse&sel=10001938" target="_blank">Halmos, Gábor</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10040839"> <a href="/gui2/?type=authors&mode=browse&sel=10040839" target="_blank">Peták, István</a> </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;30886718" mtid="30886718" target="_blank">Novel Crizotinib–GnRH conjugates revealed the significance of lysosomal trapping in GnRH-based drug delivery systems</a></div> <div class="pub-info"> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-volume">20</span> : <span class="journal-issue">22</span> <span class="page"> Paper: 5590 , 23 p. </span> <span class="year">(2019)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms20225590" target="_blank" href="https://doi.org/10.3390/ijms20225590"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="8002" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/8002"> SE Repozitórium </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="103829" target="_blank" href="http://real.mtak.hu/103829"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000502786800072" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000502786800072"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="277078" target="_blank" href="http://hdl.handle.net/2437/277078"> DEA </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="67154" target="_blank" href="https://edit.elte.hu/xmlui/handle/10831/67154"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85074657590" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85074657590"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31717403" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31717403&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:30886718 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 9</span> | Független: 8 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt: 5 | WoS/Scopus jelölt: 5 | DOI jelölt: 8 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10047778"><a href="/gui2/?type=authors&mode=browse&sel=10047778" target="_blank">Murányi József ✉ (<span class="authorship-author-name">Murányi József</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span> ; <span class="author-name" mtid="10040840"><a href="/gui2/?type=authors&mode=browse&sel=10040840" target="_blank">Varga Attila (<span class="authorship-author-name">Varga Attila</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span> ; <span class="author-name" mtid="10028916"><a href="/gui2/?type=authors&mode=browse&sel=10028916" target="_blank">Gyulavári Pál (<span class="authorship-author-name">Gyulavári Pál</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span> ; <span class="author-name" mtid="10044963"><a href="/gui2/?type=authors&mode=browse&sel=10044963" target="_blank">Pénzes Kinga (<span class="authorship-author-name">Pénzes Kinga</span> <span class="authorAux-mtmt"> sejtbiológia, biokémia</span>) </a> </span> ; <span class="author-name" mtid="10054897"><a href="/gui2/?type=authors&mode=browse&sel=10054897" target="_blank">Németh Csilla E. (<span class="authorship-author-name">Németh Csilla Emese</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet</span> ; <span class="author-name" mtid="10000786"><a href="/gui2/?type=authors&mode=browse&sel=10000786" target="_blank">Csala Miklós (<span class="authorship-author-name">Csala Miklós</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet</span> ; <span class="author-name" mtid="10046429"><a href="/gui2/?type=authors&mode=browse&sel=10046429" target="_blank">Pethő Lilla (<span class="authorship-author-name">Pethő Lilla</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Kémiai Intézet">KI</span>/MTA-ELTE Peptidkémiai Kutatócsoport</span> ; 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<span class="author-name" mtid="10034838"><a href="/gui2/?type=authors&mode=browse&sel=10034838" target="_blank">Vályi-Nagy István (<span class="authorship-author-name">Vályi-Nagy István</span> <span class="authorAux-mtmt"> Hematológia, belgyógyászat, onkológia</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;30886718" target="_blank">Novel Crizotinib–GnRH conjugates revealed the significance of lysosomal trapping in GnRH-based drug delivery systems</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">20</span> <span class="journal-issue">22</span> <span class="page"> Paper 5590. 23 p. </span> <span class="year">(2019)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms20225590" target="_blank" href="https://doi.org/10.3390/ijms20225590"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="8002" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/8002"> SE Repozitórium </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="103829" target="_blank" href="http://real.mtak.hu/103829"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000502786800072" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000502786800072"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="277078" target="_blank" href="http://hdl.handle.net/2437/277078"> DEA </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="67154" target="_blank" href="https://edit.elte.hu/xmlui/handle/10831/67154"> EDIT </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85074657590" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85074657590"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31717403" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31717403&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 9</span> | Független: 8 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt: 5 | WoS/Scopus jelölt: 5 | DOI jelölt: 8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30886718&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30886718</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="lastModified">Utolsó módosítás: 2023.09.02. 17:30 Milánkovics Róbert (PTE ÁOK admin 4) </div> </div></div>
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Targeted therapies against cancer types with more than one driver gene hold bright but elusive promise, since approved drugs are not available for all driver mutations and monotherapies often result in resistance. Targeting multiple driver genes in different pathways at the same time may provide an impact extensive enough to fight resistance. Our goal was to find synergistic drug combinations based on the availability of targeted drugs and their biological activity profiles and created an associated compound library based on driver gene-related protein targets. In this study, we would like to show that driver gene pattern based customized combination therapies are more effective than monotherapies on six cell lines and patient-derived primary cell cultures. We tested 55-102 drug combinations targeting driver genes and driver pathways for each cell line and found 25-85% of these combinations highly synergistic. Blocking 2-5 cancer pathways using only 2-3 targeted drugs was sufficient to reach high rates of tumor cell eradication at remarkably low concentrations. Our results demonstrate that the efficiency of cancer treatment may be significantly improved by combining drugs against multiple tumor specific drivers.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Zsákai, Lilian ✉ </span> <span class="author-type"> </span> ; <span class="author-name" > Sipos, Anna<sup>*</sup> </span> <span class="author-type"> </span> ; <span class="author-name" > Dobos, Judit </span> <span class="author-type"> </span> ; <span class="author-name" > Erős, Dániel </span> <span class="author-type"> </span> ; <span class="author-name" > Szántai-Kis, Csaba </span> <span class="author-type"> </span> ; <span class="author-name" > Bánhegyi, Péter </span> <span class="author-type"> </span> ; <span class="author-name" > Pató, János </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10003054"> <a href="/gui2/?type=authors&mode=browse&sel=10003054" target="_blank">Őrfi, László</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10043362"> <a href="/gui2/?type=authors&mode=browse&sel=10043362" target="_blank">Matula, Zsolt</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10048765"> <a href="/gui2/?type=authors&mode=browse&sel=10048765" target="_blank">Mikala, Gábor</a> </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;30808250" mtid="30808250" target="_blank">Targeted drug combination therapy design based on driver genes</a></div> <div class="pub-info"> <span class="journal-title">ONCOTARGET</span> <span class="journal-volume">10</span> : <span class="journal-issue">51</span> <span class="page"> pp. 5255-5266. , 12 p. </span> <span class="year">(2019)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.18632/oncotarget.26985" target="_blank" href="https://doi.org/10.18632/oncotarget.26985"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85072046058" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85072046058"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31523388" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31523388&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:30808250 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 15</span> | Független: 13 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 12 | Scopus jelölt: 15 | WoS/Scopus jelölt: 15 | DOI jelölt: 14 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
<div class="authors">
<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" >Zsákai Lilian ✉
</span>
;
<span class="author-name" >Sipos Anna<sup>*</sup>
</span>
;
<span class="author-name" >Dobos Judit
</span>
;
<span class="author-name" >Erős Dániel
</span>
;
<span class="author-name" >Szántai-Kis Csaba
</span>
;
<span class="author-name" >Bánhegyi Péter
</span>
;
<span class="author-name" >Pató János
</span>
;
<span class="author-name" mtid="10003054"><a
href="/gui2/?type=authors&mode=browse&sel=10003054" target="_blank">Őrfi László
(<span class="authorship-author-name">Őrfi László</span>
<span class="authorAux-mtmt"> Szerves- és Gyógyszerkémia</span>)
</a>
</span>
<span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet</span>
;
<span class="author-name" mtid="10043362"><a
href="/gui2/?type=authors&mode=browse&sel=10043362" target="_blank">Matula Zsolt
(<span class="authorship-author-name">Matula Zsolt</span>
<span class="authorAux-mtmt"> Őssejt-biológia</span>)
</a>
</span>
;
<span class="author-name" mtid="10048765"><a
href="/gui2/?type=authors&mode=browse&sel=10048765" target="_blank">Mikala Gábor
(<span class="authorship-author-name">Mikala Gábor</span>
<span class="authorAux-mtmt"> Hematológia</span>)
</a>
</span>
;
<span class="author-name" mtid="10000393"><a
href="/gui2/?type=authors&mode=browse&sel=10000393" target="_blank">Kéri György
(<span class="authorship-author-name">Kéri György</span>
<span class="authorAux-mtmt"> Biokémia, jelterápia</span>)
</a>
</span>
<span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span>
;
<span class="author-name" mtid="10040839"><a
href="/gui2/?type=authors&mode=browse&sel=10040839" target="_blank">Peták István
(<span class="authorship-author-name">Peták István</span>
<span class="authorAux-mtmt"> farmakológia</span>)
</a>
</span>
<span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span>
;
<span class="author-name" mtid="10034838"><a
href="/gui2/?type=authors&mode=browse&sel=10034838" target="_blank">Vályi-Nagy István
(<span class="authorship-author-name">Vályi-Nagy István</span>
<span class="authorAux-mtmt"> Hematológia, belgyógyászat, onkológia</span>)
</a>
</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;30808250" target="_blank">Targeted drug combination therapy design based on driver genes</a></div> <div> <span class="journal-title">ONCOTARGET</span>
<span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1949-2553">1949-2553</a>)</span>:
<span class="journal-volume">10</span> <span class="journal-issue">51</span>
<span class="page">
pp 5255-5266
</span> <span class="year">(2019)</span>
</div>
<div class="pub-footer">
<span class="language" xmlns="http://www.w3.org/1999/html">Nyelv:
Angol
| </span>
<span class="identifiers">
<span class="id identifier oa_GOLD" title=" Gold
">
<a style="color:blue" title="10.18632/oncotarget.26985" target="_blank" href="https://doi.org/10.18632/oncotarget.26985">
DOI
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="85072046058" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85072046058">
Scopus
</a>
</span>
<span class="id identifier oa_none" title="none">
<a style="color:blue" title="31523388" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31523388&dopt=Abstract">
PubMed
</a>
</span>
</span>
<div class="publication-citation" style="margin-left: 0.5cm;">
<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 15</span>
| Független: 13
| Függő: 2
| Nem jelölt: 0
| WoS jelölt: 12
| Scopus jelölt: 15
| WoS/Scopus jelölt: 15
| DOI jelölt: 14
</div>
<div class="publication-citation">
<a target="_blank" href="/api/publication?cond=citations.related;eq;30808250&sort=publishedYear,desc&sort=title">
Idézett közlemények száma: 5
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</div>
<div class="mtid"><span class="long-pub-mtid">Közlemény: 30808250</span>
| <span class="status-data status-VALIDATED"> Egyeztetett
</span>
Forrás Idéző
| <span class="type-subtype">Folyóiratcikk
( Szakcikk
)
</span>
| <span class="pub-category">Tudományos</span>
| <span class="publication-sourceOfData">kézi felvitel</span>
</div>
<div class="lastModified">Utolsó módosítás: 2023.09.02. 17:28 Milánkovics Róbert (PTE ÁOK admin 4)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre>
</div></div>
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Pancreatic cancer is an increasing cause of cancer related death worldwide. KRAS is the dominant oncogene in this cancer type and molecular rationale would indicate, that inhibitors of the downstream target MEK could be appropriate targeted agents, but clinical trials have failed so far to achieve statistically significant benefit in unselected patients. We aimed to identify predictive molecular biomarkers that can help to define subgroups where MEK inhibitors might be beneficial alone or in combination. Next-generation sequencing data of 50 genes in three pancreatic cancer cell lines (MiaPaCa2, BxPC3 and Panc1) were analyzed and compared to the molecular profile of 138 clinical pancreatic cancer samples to identify the molecular subtypes of pancreatic cancer these cell lines represent. Luminescent cell viability assay was used to determine the sensitivity of cell lines to kinase inhibitors. Western blot was used to analyze the pathway activity of the examined cell lines. According to our cell viability and pathway activity data on these model cell lines only cells harboring the rare G12C KRAS mutation and low EGFR expression are sensitive to single MEK inhibitor (trametinib) treatment. The common G12D KRAS mutation leads to elevated baseline Akt activity, thus treatment with single MEK inhibitors fails. However, combination of MEK and Akt inhibitors are synergistic in this case. In case of wild-type KRAS and high EGFR expression MEK inhibitor induced Akt phosphorylation leads to trametinib resistance which necessitates for MEK and EGFR or Akt inhibitor combination treatment. In all we provide strong preclinical rational and possible molecular mechanism to revisit MEK inhibitor therapy in pancreatic cancer in both monotherapy and combination, based on molecular profile analysis of pancreatic cancer samples and cell lines. According to our most remarkable finding, a small subgroup of patients with G12C KRAS mutation may still benefit from MEK inhibitor monotherapy.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10036137"> <a href="/gui2/?type=authors&mode=browse&sel=10036137" target="_blank">Brauswetter, D ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10059086"> <a href="/gui2/?type=authors&mode=browse&sel=10059086" target="_blank">Gurbi, B</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10040840"> <a href="/gui2/?type=authors&mode=browse&sel=10040840" target="_blank">Varga, A</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Varkondi, E </span> <span class="author-type"> </span> ; <span class="author-name" > Schwab, R </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10011674"> <a href="/gui2/?type=authors&mode=browse&sel=10011674" target="_blank">Banhegyi, G</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Fabian, O </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000393"> <a href="/gui2/?type=authors&mode=browse&sel=10000393" target="_blank">Keri, G</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10034838"> <a href="/gui2/?type=authors&mode=browse&sel=10034838" target="_blank">Valyi-Nagy, I</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10040839"> <a href="/gui2/?type=authors&mode=browse&sel=10040839" target="_blank">Petak, I</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;3274289" mtid="3274289" target="_blank">Molecular subtype specific efficacy of MEK inhibitors in pancreatic cancers</a></div> <div class="pub-info"> <span class="journal-title">PLOS ONE</span> <span class="journal-volume">12</span> : <span class="journal-issue">9</span> <span class="page"> Paper: e0185687 , 13 p. </span> <span class="year">(2017)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0185687" target="_blank" href="https://doi.org/10.1371/journal.pone.0185687"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="74747" target="_blank" href="http://real.mtak.hu/74747"> REAL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="4844" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/4844"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000411985200106" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000411985200106"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85032915909" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85032915909"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="28957417" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28957417&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:3274289 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 22</span> | Független: 20 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 21 | Scopus jelölt: 20 | WoS/Scopus jelölt: 22 | DOI jelölt: 21 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10036137"><a href="/gui2/?type=authors&mode=browse&sel=10036137" target="_blank">Brauswetter D ✉ (<span class="authorship-author-name">Brauswetter Diána</span> <span class="authorAux-mtmt"> patobiokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span> ; <span class="author-name" mtid="10059086"><a href="/gui2/?type=authors&mode=browse&sel=10059086" target="_blank">Gurbi B (<span class="authorship-author-name">Gurbi Bianka</span> <span class="authorAux-mtmt"> célzott daganatterápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span> ; <span class="author-name" mtid="10040840"><a href="/gui2/?type=authors&mode=browse&sel=10040840" target="_blank">Varga A (<span class="authorship-author-name">Varga Attila</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span> ; <span class="author-name" >Varkondi E </span> ; <span class="author-name" >Schwab R </span> ; <span class="author-name" mtid="10011674"><a href="/gui2/?type=authors&mode=browse&sel=10011674" target="_blank">Banhegyi G (<span class="authorship-author-name">Bánhegyi Gábor</span> <span class="authorAux-mtmt"> Biokémia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet</span> ; <span class="author-name" >Fabian O </span> ; <span class="author-name" mtid="10000393"><a href="/gui2/?type=authors&mode=browse&sel=10000393" target="_blank">Keri G (<span class="authorship-author-name">Kéri György</span> <span class="authorAux-mtmt"> Biokémia, jelterápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span> ; <span class="author-name" mtid="10034838"><a href="/gui2/?type=authors&mode=browse&sel=10034838" target="_blank">Valyi-Nagy I (<span class="authorship-author-name">Vályi-Nagy István</span> <span class="authorAux-mtmt"> Hematológia, belgyógyászat, onkológia</span>) </a> </span> ; <span class="author-name" mtid="10040839"><a href="/gui2/?type=authors&mode=browse&sel=10040839" target="_blank">Petak I (<span class="authorship-author-name">Peták István</span> <span class="authorAux-mtmt"> farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;3274289" target="_blank">Molecular subtype specific efficacy of MEK inhibitors in pancreatic cancers</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">9</span> <span class="page"> Paper e0185687. 13 p. </span> <span class="year">(2017)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0185687" target="_blank" href="https://doi.org/10.1371/journal.pone.0185687"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="74747" target="_blank" href="http://real.mtak.hu/74747"> REAL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="4844" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/4844"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000411985200106" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000411985200106"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85032915909" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85032915909"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="28957417" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28957417&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 22</span> | Független: 20 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 21 | Scopus jelölt: 20 | WoS/Scopus jelölt: 22 | DOI jelölt: 21 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3274289&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3274289</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3274289</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2022.01.05. 11:38 Sághi-Keszthelyi Anna (SE_KK_Admin5_SKA, admin) </div> </div></div>
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Export Date: 2 June 2021
CODEN: NRDDA
Correspondence Address: Peták, I.; KPS Medical Biotechnology, 5 Ribary, 1022 Budapest, Hungary; email: petak@kps.hu
Chemicals/CAS: bexarotene, 153559-49-0; carboplatin, 41575-94-4; cetuximab, 205923-56-4; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; docetaxel, 114977-28-5; epidermal growth factor receptor 2, 137632-09-8; epidermal growth factor receptor 3, 497121-54-7; erlotinib, 183319-69-9, 183321-74-6; fluorouracil, 51-21-8; folinic acid, 58-05-9; gefitinib, 184475-35-2, 184475-55-6, 184475-56-7; gemcitabine, 103882-84-4; irinotecan, 100286-90-6; lapatinib, 231277-92-2, 388082-78-8, 437755-78-7; mitogen activated protein kinase, 142243-02-5; oxaliplatin, 61825-94-3; paclitaxel, 33069-62-4; panitumumab, 339177-26-3; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase, 210488-47-4; sorafenib, 284461-73-0; trastuzumab, 180288-69-1; vandetanib, 338992-00-0, 338992-48-6, 443913-73-3; Antineoplastic Agents; Biological Markers; EGFR protein, human, 2.7.10.1; HER2 protein, human; Receptor, Epidermal Growth Factor, 2.7.10.1; Receptor, erbB-2, 2.7.10.1
Tradenames: erbitux, Bristol Myers Squibb; erbitux, Lilly; herceptin, Genentech; herceptin, Hoffmann La Roche; iressa, Astra Zeneca; tarceva, Hoffmann La Roche; tyverb, Glaxo SmithKline; vectibix, Amgen
Manufacturers: Amgen; Astra Zeneca; Bristol Myers Squibb; Genentech; Glaxo SmithKline; Hoffmann La Roche; Lilly
Cited By :48
Export Date: 10 June 2021
CODEN: NRDDA
Correspondence Address: Peták, I.; KPS Medical Biotechnology, 5 Ribary, 1022 Budapest, Hungary; email: petak@kps.hu
Funding Agency and Grant Number: [KKKII-05/2005]; [NKFP_07_A2-NANODRUG]; [TECH_08_A2-STEMKILL]; [NAP_BIO_06-FLU_DRUG]; [OTKA-T046665]
Funding text: This work was supported by grants (KKKII-05/2005, NKFP_07_A2-NANODRUG, TECH_08_A2-STEMKILL, NAP_BIO_06-FLU_DRUG and OTKA-T046665).
Cited By :48
Export Date: 13 September 2021
CODEN: NRDDA
Correspondence Address: Peták, I.; KPS Medical Biotechnology, 5 Ribary, 1022 Budapest, Hungary; email: petak@kps.hu
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In the 1990s, the breast cancer drug trastuzumab (Herceptin; Genentech/roche) - an antibody specific for human epidermal growth factor receptor 2 (HER2; also known as ERBB2) - was approved based on trials in which HER2 expression levels were used to select patients in clinical trials. This provided support for analogous efforts for drugs that target the epidermal growth factor receptor (EGFR). However, the development of these drugs, such as cetuximab (Erbitux; Bristol-Myers Squibb/Lilly) and gefitinib (Iressa; AstraZeneca), has revealed that EGFR expression is an insufficient and unreliable biomarker to select patients for EGFR-targeted therapies in both lung and colon cancer. indeed, evidence on patient populations that are likely to respond to such therapies, on the basis of specific mutations in proteins of the targeted pathway, has only recently been clinically validated and incorporated into some of the drug labels. This article highlights lessons learned from the development of the first drugs targeting the EGFR family and discusses strategies to decrease the risk of failure in clinical development by more effectively integrating molecular diagnostics into anticancer drug discovery.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10040839"> <a href="/gui2/?type=authors&mode=browse&sel=10040839" target="_blank">Petak, I ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Schwab, R </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10003054"> <a href="/gui2/?type=authors&mode=browse&sel=10003054" target="_blank">Orfi, L</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="1178787"> <a href="/gui2/?type=authors&mode=browse&sel=1178787" target="_blank">Kopper, L</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10000393"> <a href="/gui2/?type=authors&mode=browse&sel=10000393" target="_blank">Keri, G</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1370718" mtid="1370718" target="_blank">Integrating molecular diagnostics into anticancer drug discovery</a></div> <div class="pub-info"> <span class="journal-title">NATURE REVIEWS DRUG DISCOVERY</span> <span class="journal-volume">9</span> : <span class="journal-issue">7</span> <span class="page"> pp. 523-535. , 13 p. </span> <span class="year">(2010)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/nrd3135" target="_blank" href="https://doi.org/10.1038/nrd3135"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000280143900023" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000280143900023"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="77954241944" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-77954241944"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="20531274" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20531274&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1370718 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 55</span> | Független: 49 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 47 | Scopus jelölt: 51 | WoS/Scopus jelölt: 52 | DOI jelölt: 47 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" mtid="10040839"><a
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(<span class="authorship-author-name">Peták István</span>
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<span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span>
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<span class="author-name" >Schwab R
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;
<span class="author-name" mtid="10003054"><a
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<span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet</span>
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<span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span>
;
<span class="author-name" mtid="10000393"><a
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<span class="authorAux-mtmt"> Biokémia, jelterápia</span>)
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<span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;1370718" target="_blank">Integrating molecular diagnostics into anticancer drug discovery</a></div> <div> <span class="journal-title">NATURE REVIEWS DRUG DISCOVERY</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1474-1776">1474-1776</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1474-1784">1474-1784</a>)</span>:
<span class="journal-volume">9</span> <span class="journal-issue">7</span>
<span class="page">
pp 523-535
</span> <span class="year">(2010)</span>
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<div class="pub-footer">
<span class="language" xmlns="http://www.w3.org/1999/html">Nyelv:
Angol
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<span class="identifiers">
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<span class="id identifier oa_none" title="none">
<a style="color:blue" title="000280143900023" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000280143900023">
WoS
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<a style="color:blue" title="77954241944" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-77954241944">
Scopus
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<a style="color:blue" title="20531274" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20531274&dopt=Abstract">
PubMed
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<div class="publication-citation" style="margin-left: 0.5cm;">
<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 55</span>
| Független: 49
| Függő: 6
| Nem jelölt: 0
| WoS jelölt: 47
| Scopus jelölt: 51
| WoS/Scopus jelölt: 52
| DOI jelölt: 47
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<div class="publication-citation">
<a target="_blank" href="/api/publication?cond=citations.related;eq;1370718&sort=publishedYear,desc&sort=title">
Idézett közlemények száma: 15
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 1370718</span>
| <span class="status-data status-VALIDATED"> Egyeztetett
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<span class="oldId">Régi azonosító: 1370718</span> |
Forrás Idéző
| <span class="type-subtype">Folyóiratcikk
( Szakcikk
)
</span>
| <span class="pub-category">Tudományos</span>
| <span class="publication-sourceOfData">WOS</span>
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<div class="lastModified">Utolsó módosítás: 2022.10.21. 01:47 MTMT API (MTMT API user, admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :48
Export Date: 2 June 2021
CODEN: NRDDA
Correspondence Address: Peták, I.; KPS Medical Biotechnology, 5 Ribary, 1022 Budapest, Hungary; email: petak@kps.hu
Chemicals/CAS: bexarotene, 153559-49-0; carboplatin, 41575-94-4; cetuximab, 205923-56-4; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2...</pre>
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10087038"> <a href="/gui2/?type=authors&mode=browse&sel=10087038" target="_blank">Pinter, F</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10023572"> <a href="/gui2/?type=authors&mode=browse&sel=10023572" target="_blank">Papay, J</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Almasi, A </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10004659"> <a href="/gui2/?type=authors&mode=browse&sel=10004659" target="_blank">Sapi, Z</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10015440"> <a href="/gui2/?type=authors&mode=browse&sel=10015440" target="_blank">Szabo, E</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Kanya, M </span> <span class="author-type"> </span> ; <span class="author-name" > Tamasi, A </span> <span class="author-type"> </span> ; <span class="author-name" > Jori, B </span> <span class="author-type"> </span> ; <span class="author-name" > Varkondi, E </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10003072"> <a href="/gui2/?type=authors&mode=browse&sel=10003072" target="_blank">Moldvay, J</a> </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1281160" mtid="1281160" target="_blank">Epidermal growth factor receptor (EGFR) high gene copy number and activating mutations in lung adenocarcinomas are not consistently accompanied by positivity for EGFR protein by standard immunohistochemistry</a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF MOLECULAR DIAGNOSTICS</span> <span class="journal-volume">10</span> : <span class="journal-issue">2</span> <span class="page"> pp. 160-168. , 9 p. </span> <span class="year">(2008)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.2353/jmoldx.2008.070125" target="_blank" href="https://doi.org/10.2353/jmoldx.2008.070125"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000253874500008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000253874500008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41149169801" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-41149169801"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="18258923" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18258923&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1281160 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 80</span> | Független: 65 | Függő: 15 | Nem jelölt: 0 | WoS jelölt: 55 | Scopus jelölt: 66 | WoS/Scopus jelölt: 71 | DOI jelölt: 61 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10087038"><a href="/gui2/?type=authors&mode=browse&sel=10087038" target="_blank">Pinter F (<span class="authorship-author-name">Pintér Ferenc</span> <span class="authorAux-mtmt"> Patológia, orvostudomány</span>) </a> </span> ; <span class="author-name" mtid="10023572"><a href="/gui2/?type=authors&mode=browse&sel=10023572" target="_blank">Papay J (<span class="authorship-author-name">Pápay Judit</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span> ; <span class="author-name" >Almasi A </span> ; <span class="author-name" mtid="10004659"><a href="/gui2/?type=authors&mode=browse&sel=10004659" target="_blank">Sapi Z (<span class="authorship-author-name">Sápi Zoltán</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span> ; <span class="author-name" mtid="10015440"><a href="/gui2/?type=authors&mode=browse&sel=10015440" target="_blank">Szabo E (<span class="authorship-author-name">Z. Szabó Edit</span> <span class="authorAux-mtmt"> Peptid-Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span> ; <span class="author-name" >Kanya M </span> ; <span class="author-name" >Tamasi A </span> ; <span class="author-name" >Jori B </span> ; <span class="author-name" >Varkondi E </span> ; <span class="author-name" mtid="10003072"><a href="/gui2/?type=authors&mode=browse&sel=10003072" target="_blank">Moldvay J (<span class="authorship-author-name">Moldvay Judit</span> <span class="authorAux-mtmt"> Tüdõgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> ; <span class="author-name" mtid="10024048"><a href="/gui2/?type=authors&mode=browse&sel=10024048" target="_blank">Szondy K (<span class="authorship-author-name">Szondy Klára</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> ; <span class="author-name" mtid="10000393"><a href="/gui2/?type=authors&mode=browse&sel=10000393" target="_blank">Keri G (<span class="authorship-author-name">Kéri György</span> <span class="authorAux-mtmt"> Biokémia, jelterápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span> ; <span class="author-name" >Dominici M </span> ; <span class="author-name" >Conte P </span> ; <span class="author-name" mtid="10000834"><a href="/gui2/?type=authors&mode=browse&sel=10000834" target="_blank">Eckhardt S (<span class="authorship-author-name">Eckhardt Sándor</span> <span class="authorAux-mtmt"> Klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ; <span class="author-name" mtid="1178787"><a href="/gui2/?type=authors&mode=browse&sel=1178787" target="_blank">Kopper L (<span class="authorship-author-name">Kopper László</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span> ; <span class="author-name" >Schwab R </span> ; <span class="author-name" mtid="10040839"><a href="/gui2/?type=authors&mode=browse&sel=10040839" target="_blank">Petak I ✉ (<span class="authorship-author-name">Peták István</span> <span class="authorAux-mtmt"> farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;1281160" target="_blank">Epidermal growth factor receptor (EGFR) high gene copy number and activating mutations in lung adenocarcinomas are not consistently accompanied by positivity for EGFR protein by standard immunohistochemistry</a></div> <div> <span class="journal-title">JOURNAL OF MOLECULAR DIAGNOSTICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1525-1578">1525-1578</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1943-7811">1943-7811</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">2</span> <span class="page"> pp 160-168 </span> <span class="year">(2008)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.2353/jmoldx.2008.070125" target="_blank" href="https://doi.org/10.2353/jmoldx.2008.070125"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000253874500008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000253874500008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41149169801" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-41149169801"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="18258923" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18258923&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 80</span> | Független: 65 | Függő: 15 | Nem jelölt: 0 | WoS jelölt: 55 | Scopus jelölt: 66 | WoS/Scopus jelölt: 71 | DOI jelölt: 61 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1281160&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1281160</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 1281160</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2023.09.01. 09:05 Nagyné Tari Emese (SZTE admin5) </div> </div></div>
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Correspondence Address: Houghton, J.A.; Division of Experimental Hematology, 332 North Lauderdale, Memphis, TN 38105, United States; email: janet.houghton@stjude.org
Chemicals/CAS: caspase 8
Funding details: National Institutes of Health, NIH, ROI CA 32613
Funding details: National Cancer Institute, NCI, P30CA021765, R01CA032613
Funding details: St. Jude Children's Research Hospital
Funding details: American Lebanese Syrian Associated Charities, ALSAC
Funding text 1: Received: May 22,2001: accepted: June 5, 2001 CorrespoIldeIlce: Janet A HOUGHTON; Division of Experimental Hematology, Department of Hematology-Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA; Tel: (901)495-3456, fax: (901)523-2622, e-mail: janet.houghton@sljude.org * This research was supported by NIH Awards ROI CA 32613, the Cancer Center Support (CORE) Grant CA 21765, and by the American Lebanese Syrian Associated Charities. 1. Petak was supported in part by a scholarship from the Fulbright Program, and by the 1" Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary
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Death ligands (TNF, FasL, TRAIL) and their respective death receptor signaling pathways can be used to induce tumor cells to undergo apoptosis. Chemotherapeutic drugs can induce apoptosis and the upregulation of death ligands or their receptors. Downstream events following cytotoxic stress-induced DNA damage and the signaling pathways that lead to the induction of apoptosis may be either dependent or independent of death receptor signaling. The involvement of the Fas signaling pathway in chemotherapy-induced apoptosis has been the most extensively studied, with the current emergence of information on the TRAIL signaling pathway. Fas-mediated and chemotherapy-induced apoptosis can converge at the level of the receptor, FasL, DISC formation, activation of the initiator caspase-8, at the level of the mitochondria, or at the level of downstream effector caspase activation. Convergence is influenced by the specific form of DNA damage, the cellular environment, and the specific pathway(s) by which death receptor-mediated or drug-mediated apoptosis are induced. This review discusses the different levels of interaction between signaling pathways in the different forms of cell death.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10040839"> <a href="/gui2/?type=authors&mode=browse&sel=10040839" target="_blank">Petak, I</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Houghton, JA ✉ </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;3048770" mtid="3048770" target="_blank">Shared pathways: Death receptors and cytotoxic drugs in cancer therapy</a></div> <div class="pub-info"> <span class="journal-title">PATHOLOGY AND ONCOLOGY RESEARCH</span> <span class="journal-volume">7</span> : <span class="journal-issue">2</span> <span class="page"> pp. 95-106. , 12 p. </span> <span class="year">(2001)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1007/BF03032574" target="_blank" href="https://doi.org/10.1007/BF03032574"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0034899716" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0034899716"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="11458271" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11458271&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:3048770 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Összefoglaló cikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 133</span> | Független: 131 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 42 | Scopus jelölt: 132 | WoS/Scopus jelölt: 132 | DOI jelölt: 111 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<span class="authorAux-mtmt"> farmakológia</span>)
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;3048770" target="_blank">Shared pathways: Death receptors and cytotoxic drugs in cancer therapy</a></div> <div> <span class="journal-title">PATHOLOGY AND ONCOLOGY RESEARCH</span>
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :128
Export Date: 2 June 2021
CODEN: POREF
Correspondence Address: Houghton, J.A.; Division of Experimental Hematology, 332 North Lauderdale, Memphis, TN 38105, United States; email: janet.houghton@stjude.org
Chemicals/CAS: caspase 8
Funding details: National Institut...</pre>
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