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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Funding Agency and Grant Number: University of Pecs
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(2013) PLOS ONE 1932-6203 8 1</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10019106&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10019106&quot; target=&quot;_blank&quot;&gt;Rakosy, Z&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10020957&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10020957&quot; target=&quot;_blank&quot;&gt;Ecsedi, S&lt;sup&gt;*&lt;/sup&gt;&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Toth, R &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10034960&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10034960&quot; target=&quot;_blank&quot;&gt;Vizkeleti, L&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Herandez-Vargas, H &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10036222&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10036222&quot; target=&quot;_blank&quot;&gt;Lazar, V&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10029732&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10029732&quot; target=&quot;_blank&quot;&gt;Emri, G&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10018856&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10018856&quot; target=&quot;_blank&quot;&gt;Szatmari, I&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; 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&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;2206458&quot; target=&quot;_blank&quot;&gt;Integrative genomics identifies gene signature associated with melanoma ulceration.&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;PLOS ONE&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;( &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1932-6203&quot;&gt;1932-6203&lt;/a&gt;)&lt;/span&gt;:
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	&lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Nyelv:
			Angol
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				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q1&lt;/div&gt;
			&lt;div class=&quot;journal-subject&quot;&gt;Pedagógiai Tudományos Bizottság II. FTO PedTB [1901-]&amp;nbsp;&amp;nbsp;&amp;nbsp;A&lt;/div&gt;
			&lt;div class=&quot;journal-subject&quot;&gt;Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&amp;nbsp;&amp;nbsp;&amp;nbsp;A nemzetközi&lt;/div&gt;
			&lt;div class=&quot;journal-subject&quot;&gt;Regionális Tudományok Bizottsága IXGJO RTB [1901-]&amp;nbsp;&amp;nbsp;&amp;nbsp;B nemzetközi&lt;/div&gt;
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		| Független: 23
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.01.15. 13:31 Milánkovics Róbert (PTE ÁOK admin 4)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: * Megosztott szerzőség&lt;/pre&gt;
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located on 9p21,
occurs frequently in familial and sporadic melanomas. Beside 
CDKN2A, other genes 
(e.g., CDKN2B, and ARF/p14(ARF), long considered distinct from 
CDKN2A) on this
locus are often deleted or mutated in a large number of tumors 
including glioma, 
bladder cancer, and lung cancer. The aim of this study was to 
evaluate the
deletion pattern of the 9p21 locus on a cell-by-cell basis in a 
large number of
melanoma samples using fluorescence in situ hybridization 
(FISH). In an analysis 
of 81 primary lesions targeting the 9p21 region and chromosome 9 
centromere, high
frequency of 9p21 loss (84%) was found. Deletion of 9p21 was 
present in both
early- and late-stage melanomas with similar frequencies. Extra 
9p21 copies were 
rarely seen; they were always associated with polysomy 9 and 
were observed only
in advanced stage melanomas (6 tumors). This FISH study 
strengthens the
hypothesis that the loss of 9p21 occurs frequently in primary 
melanoma, that the 
deletion is present in early and late stages of the disease with 
similar
frequency, and that it affects a large extent of the locus.</abstractText>
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      <abstractText>Copy number alterations of the epidermal growth factor receptor (EGFR)
gene have been extensively analyzed in different cancers, but no data
ate available for primary malignant melanoma. The aim of the present
study was to simultaneously investigate the EGFR gene and chromosome 7
copy number alterations in 81 cutaneous malignant melanomas by
interphase FISH and correlate the data with clinicopathological
parameters of patients. EGFR mRNA levels were detected by Affymetrix
GeneChip Human Genome U133 Plus 2.0 expression arrays for 16 lesions.
Both increased gene dosage and chromosome 7 alterations were found in
70% of tumors. Extra EGFR copies were detected in an additional 10% of
samples. Polysomy 7 was associated with EGFR gene amplification.
Significant correlation was found between EGFR alterations and
histological subtypes, tumor thickness, ulceration and metastases
formation. Amplification was significantly higher in lesions that
developed metastases within 2 years after surgical excision of the
primary tumor. Gene copy alterations were associated with elevated mRNA
expression in 77% of lesions when compared to tumors with disomic EGFR
status, the correlation was not directly proportional to gene copy
number. Associations between protein expression and mRNA levels were
even less prominent. In conclusion, our study indicates that
amplification of the EGFR gene and polysomy 7 are frequent alterations
in primary melanomas and are associated with bad prognosis. Further
studies are required to clarify whether melanoma patients with EGFR
alterations can benefit from anti-EGFR therapy. (C) 2007 Wiley-Liss,
Inc.</abstractText>
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      <label>Rakosy Z et al. EGFR gene copy number alterations in primary cutaneous malignant melanomas are associated with poor prognosis. 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      <label>Szekvolgyi L et al. Ribonucleoprotein-masked nicks at 50-kbp intervals in the eukaryotic genomic DNA. (2007) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 0027-8424 1091-6490 104 38 14964-14969</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10012997&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10012997&quot; target=&quot;_blank&quot;&gt;Szekvolgyi, L&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10019106&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10019106&quot; target=&quot;_blank&quot;&gt;Rakosy, Z&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10013012&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10013012&quot; target=&quot;_blank&quot;&gt;Balint, LB&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; 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&lt;div class=&quot;pub-info&quot;&gt; &lt;span class=&quot;journal-title&quot;&gt;PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA&lt;/span&gt; &lt;span class=&quot;journal-volume&quot;&gt;104&lt;/span&gt; : &lt;span class=&quot;journal-issue&quot;&gt;38&lt;/span&gt; &lt;span class=&quot;page&quot;&gt; pp. 14964-14969. , 6 p. &lt;/span&gt; &lt;span class=&quot;year&quot;&gt;(2007)&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;pub-end&quot;&gt;&lt;div class=&quot;identifier-list&quot;&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;10.1073/pnas.0702269104&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1073/pnas.0702269104&quot;&gt; DOI &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_CLOSED&quot; title=&quot; Zárt &quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;3438&quot; target=&quot;_blank&quot; 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            (&lt;span class=&quot;authorship-author-name&quot;&gt;Székvölgyi Lóránt&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Kromatin szerkezet&lt;/span&gt;)
			&lt;/a&gt;
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Debreceni Egyetem&quot;&gt;DE&lt;/span&gt;/&lt;span title=&quot;Orvos- és Egészségtudományi Centrum&quot;&gt;OEC&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Biofizikai és Sejtbiológiai Intézet&lt;/span&gt;
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            (&lt;span class=&quot;authorship-author-name&quot;&gt;Bálint Bálint László&lt;/span&gt;
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            (&lt;span class=&quot;authorship-author-name&quot;&gt;Imre László&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; sejtbiológia&lt;/span&gt;)
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&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;236711&quot; target=&quot;_blank&quot;&gt;Ribonucleoprotein-masked nicks at 50-kbp intervals in the eukaryotic genomic DNA&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/0027-8424&quot;&gt;0027-8424&lt;/a&gt; &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1091-6490&quot;&gt;1091-6490&lt;/a&gt;)&lt;/span&gt;:
		&lt;span class=&quot;journal-volume&quot;&gt;104&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;38&lt;/span&gt;
&lt;span class=&quot;page&quot;&gt;
	pp 14964-14969
			
&lt;/span&gt;		 &lt;span class=&quot;year&quot;&gt;(2007)&lt;/span&gt;  
    &lt;/div&gt;
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							&lt;a style=&quot;color:blue&quot; title=&quot;10.1073/pnas.0702269104&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1073/pnas.0702269104&quot;&gt;
									DOI
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&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;3438&quot; target=&quot;_blank&quot; href=&quot;http://hdl.handle.net/2437/3438&quot;&gt;
									DEA
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						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;000249715100018&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/000249715100018&quot;&gt;
									WoS
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									Scopus
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						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;17848525&quot; target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=17848525&amp;dopt=Abstract&quot;&gt;
									PubMed
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						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:black&quot; title=&quot;http://www.pnas.org/content/104/38/14964.full.pdf+html&quot; target=&quot;_blank&quot; href=&quot;http://www.pnas.org/content/104/38/14964.full.pdf+html&quot;&gt;
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	&lt;OnlyViewableByAuthor&gt;&lt;div class=&quot;ratings&quot;&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Multidisciplinary&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;D1&lt;/div&gt;
			&lt;div class=&quot;journal-subject&quot;&gt;X. Földtudományok Osztálya XFO&amp;nbsp;&amp;nbsp;&amp;nbsp;A&lt;/div&gt;
			&lt;div class=&quot;journal-subject&quot;&gt;Regionális Tudományok Bizottsága IXGJO RTB [1901-]&amp;nbsp;&amp;nbsp;&amp;nbsp;A nemzetközi&lt;/div&gt;
			&lt;div class=&quot;journal-subject&quot;&gt;Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&amp;nbsp;&amp;nbsp;&amp;nbsp;A nemzetközi&lt;/div&gt;
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		| Független: 21
		| Függő: 11
		| Nem jelölt: 0
		| WoS jelölt: 22 
		|  Scopus jelölt:&amp;nbsp;21 
		|  WoS/Scopus jelölt:&amp;nbsp;22 
		|  DOI jelölt:&amp;nbsp;21 
		
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    &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 236711&lt;/span&gt;
    | &lt;span class=&quot;status-data status-ADMIN_APPROVED&quot;&gt; 	Admin láttamozott
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	&lt;span class=&quot;oldId&quot;&gt;Régi azonosító: 236711&lt;/span&gt; | 
	
Forrás	 Idéző
	
	
    | &lt;span class=&quot;type-subtype&quot;&gt;Folyóiratcikk
			( Szakcikk
			
			)
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      		| &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt;
	| &lt;span class=&quot;publication-sourceOfData&quot;&gt;kézi felvitel&lt;/span&gt;
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2019.03.28. 16:07 Király Magdolna (DE admin 5)
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        &lt;div class=&quot;lockedBy&quot;&gt;Központi kezelésű 2022.07.26. 09:50  Wolf György (MTMT Központi admin)
        &lt;/div&gt;


	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Megjegyzés-21568824
Z9: 4
WC: Multidisciplinary Sciences&lt;/pre&gt;
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