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Division of Radiology and Imaging Science, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary
ELKH-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, Debrecen, 4032, Hungary
Horvath Csaba Laboratory of Bioseparation Sciences, Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary
Vitrolink Kft., Debrecen, 4033, Hungary
Institute for Nuclear Research, Debrecen, 4026, Hungary
Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, 751 85, Sweden
Institute of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, 6725, Hungary
Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary
Department of Behavioural Sciences, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary
Department of Old Age Psychiatry, Institute of Psychiatry Psychology and Neuroscience, King’s College London, London, SE5 8AF, United Kingdom
Centre for Age-Related Medicine, SESAM, Stavanger University Hospital, Stavanger, 4011, Norway
Export Date: 4 January 2022
Correspondence Address: Hortobágyi, T.; ELKH-DE Cerebrovascular and Neurodegenerative Research Group, Hungary; email: tibor.hortobagyi@kcl.ac.uk
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Comparison of Semi-Quantitative Scoring and Artificial Intelligence Aided Digital Image Analysis of Chromogenic Immunohistochemistry
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Semi-quantitative scoring is a method that is widely used to estimate the quantity of proteins on chromogen-labelled immunohistochemical (IHC) tissue sections. However, it suffers from several disadvantages, including its lack of objectivity and the fact that it is a time-consuming process. Our aim was to test a recently established artificial intelligence (AI)-aided digital image analysis platform, Pathronus, and to compare it to conventional scoring by five observers on chromogenic IHC-stained slides belonging to three experimental groups. Because Pathronus operates on grayscale 0-255 values, we transformed the data to a seven-point scale for use by pathologists and scientists. The accuracy of these methods was evaluated by comparing statistical significance among groups with quantitative fluorescent IHC reference data on subsequent tissue sections. The pairwise inter-rater reliability of the scoring and converted Pathronus data varied from poor to moderate with Cohen's kappa, and overall agreement was poor within every experimental group using Fleiss' kappa. Only the original and converted that were obtained from Pathronus original were able to reproduce the statistical significance among the groups that were determined by the reference method. In this study, we present an AI-aided software that can identify cells of interest, differentiate among organelles, protein specific chromogenic labelling, and nuclear counterstaining after an initial training period, providing a feasible and more accurate alternative to semi-quantitative scoring.
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<span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Pathológiai Intézet; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Neurológiai Tanszék; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/MTA-DE Cerebrovascularis és Neurodegeneratív Kutatócsoport</span>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;32553991" target="_blank">Comparison of Semi-Quantitative Scoring and Artificial Intelligence Aided Digital Image Analysis of Chromogenic Immunohistochemistry</a></div> <div> <span class="journal-title">BIOMOLECULES</span>
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<div class="funder"> (UNKP-21-3), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP, (Nemzeti Agykutatási Program KTIA_13_NAP-A-II/7), (NKFIH_SNN_132999) Támogató: NKFIH, (SZTE ÁOK-KKA No. 5S 567 (A202)) </div>
<div class="lastModified">Utolsó módosítás: 2023.10.12. 15:13 Belházyné Szombathelyi Ágnes (SZTE admin5)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Division of Radiology and Imaging Science, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary
ELKH-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, Debrecen, 4032, Hungary
Horvath Csaba Laboratory of Bioseparation Sciences, Research Center for...</pre>
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Osteopontin (OPN), a multifunctional phosphoglycoprotein also presents in saliva, plays a crucial role in tumour progression, inflammation and mucosal protection. Mucosal barrier injury due to high-dose conditioning regimen administered during autologous and allogeneic peripheral stem cell transplantation (APSCT) has neither efficient therapy nor established biomarkers. Our aim was to assess the biomarker role of OPN during APSCT, with primary focus on oral mucositis (OM). Serum and salivary OPN levels were determined by ELISA in 10 patients during APSCT at four stages of transplantation (day -3/-7, 0, +7, +14), and in 23 respective healthy controls. Results: There was a negative correlation between both salivary and serum OPN levels and grade of OM severity during APSCT (r = -0.791, p = 0.019; r = -0.973, p = 0.001). Salivary OPN increased at days +7 (p = 0.011) and +14 (p = 0.034) compared to controls. Among patients, it was higher at day +14 compared to the time of admission (day -3/-7) (p = 0.039) and transplantation (day 0) (p = 0.011). Serum OPN remained elevated at all four stages of transplantation compared to controls (p = 0.013, p = 0.02, p = 0.011, p = 0.028). During APSCT elevated salivary OPN is a potential non-invasive biomarker of oral mucositis whereas the importance of high serum OPN warrants further studies.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Pasha, Terouz </span> <span class="author-type"> </span> ; <span class="author-name" > Zatorska, Anna<sup>*</sup> </span> <span class="author-type"> </span> ; <span class="author-name" > Sharipov, Daulet<sup>*</sup> </span> <span class="author-type"> </span> ; <span class="author-name" > Rogelj, Boris </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10017334"> <a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobágyi, Tibor</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Hirth, Frank ✉ </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;32554653" mtid="32554653" target="_blank">Karyopherin abnormalities in neurodegenerative proteinopathies</a></div> <div class="pub-info"> <span class="journal-title">BRAIN</span> <span class="journal-volume">144</span> : <span class="journal-issue">10</span> <span class="page"> pp. 2915-2932. , 18 p. </span> <span class="year">(2021)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1093/brain/awab201" target="_blank" href="https://doi.org/10.1093/brain/awab201"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000733375400006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000733375400006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85113789602" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85113789602"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="34019093" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=34019093&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://academic.oup.com/brain/article/144/10/2915/6279742" target="_blank" href="https://academic.oup.com/brain/article/144/10/2915/6279742"> Egyéb URL </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:32554653 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Összefoglaló cikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 17</span> | Független: 16 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 17 | Scopus jelölt: 11 | WoS/Scopus jelölt: 17 | DOI jelölt: 17 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Pasha Terouz </span> ; 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Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary
MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, Debrecen, 4032, Hungary
Horvath Csaba Memorial Institute of Bioanalytical Research, Research Centre for Molecular Medicine, University of Debrecen, Debrecen, 4032, Hungary
Vitrolink Ltd., Debrecen, 4033, Hungary
Institute for Nuclear Research of the Hungarian Academy of Sciences (ATOMKI), Debrecen, 4026, Hungary
Institute of Pathology, Faculty of Medicine, University of Szeged, Szeged, 6725, Hungary
Department of Old Age Psychiatry, Institute of Psychiatry Psychology and Neuroscience, King’s College London, London, SE5 8AF, United Kingdom
Centre for Age-Related Medicine, SESAM, Stavanger University Hospital, Stavanger, 4011, Norway
Export Date: 28 May 2021
Correspondence Address: Hortobágyi, T.; MTA-DE Cerebrovascular and Neurodegenerative Research Group, Hungary; email: tibor.hortobagyi@kcl.ac.uk
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10059916"> <a href="/gui2/?type=authors&mode=browse&sel=10059916" target="_blank">Bencze, János</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10055694"> <a href="/gui2/?type=authors&mode=browse&sel=10055694" target="_blank">Szarka, Máté</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Bencs, Viktor </span> <span class="author-type"> </span> ; <span class="author-name" > Szabó, Renáta Nóra </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10078363"> <a href="/gui2/?type=authors&mode=browse&sel=10078363" target="_blank">Módis, V. László</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Aarsland, Dag </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10017334"> <a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobágyi, Tibor ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;31153347" mtid="31153347" target="_blank">Lemur Tyrosine Kinase 2 (LMTK2) Level Inversely Correlates with Phospho-Tau in Neuropathological Stages of Alzheimer’s Disease</a></div> <div class="pub-info"> <span class="journal-title">BRAIN SCIENCES</span> <span class="journal-volume">10</span> : <span class="journal-issue">2</span> <span class="page"> Paper: 68 , 13 p. </span> <span class="year">(2020)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/brainsci10020068" target="_blank" href="https://doi.org/10.3390/brainsci10020068"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000519243400011" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000519243400011"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85078993240" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85078993240"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="32012723" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=32012723&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.mdpi.com/2076-3425/10/2/68" target="_blank" href="https://www.mdpi.com/2076-3425/10/2/68"> Egyéb URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="18644" target="_blank" href="http://publicatio.bibl.u-szeged.hu/18644"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:31153347 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 2 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt: 6 | WoS/Scopus jelölt: 6 | DOI jelölt: 5 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="lockedBy">Zárolva 2021.02.09. 10:48 Zolnai Dóra (ATKI admin)</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary
MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, Debrecen, 4032, Hungary
Horvath Csaba Memorial Institute of Bioanalytical Research, Research Centre for Molecular Medicine, University of Debrece...</pre>
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10062217"> <a href="/gui2/?type=authors&mode=browse&sel=10062217" target="_blank">Gebri, Enikő Zsuzsa</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10005475"> <a href="/gui2/?type=authors&mode=browse&sel=10005475" target="_blank">Kiss, Attila</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10060158"> <a href="/gui2/?type=authors&mode=browse&sel=10060158" target="_blank">Tóth, Ferenc</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10017334"> <a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobágyi, Tibor ✉</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;31618650" mtid="31618650" target="_blank">Female sex as an independent prognostic factor in the development of oral mucositis during autologous peripheral stem cell transplantation</a></div> <div class="pub-info"> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-volume">10</span> : <span class="journal-issue">1</span> <span class="page"> Paper: 15898 , 12 p. </span> <span class="year">(2020)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-020-72592-5" target="_blank" href="https://doi.org/10.1038/s41598-020-72592-5"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000577346400013" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000577346400013"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85091623657" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85091623657"> Scopus </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="22850" target="_blank" href="http://publicatio.bibl.u-szeged.hu/22850"> SZTE Publicatio </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:31618650 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 9 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt: 7 | WoS/Scopus jelölt: 11 | DOI jelölt: 11 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10062217"><a href="/gui2/?type=authors&mode=browse&sel=10062217" target="_blank">Gebri Enikő Zsuzsa (<span class="authorship-author-name">Gebri Enikő</span> <span class="authorAux-mtmt"> tanársegéd</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Dentoalveoláris Sebészeti nem önálló Tanszék</span> ; <span class="author-name" mtid="10005475"><a href="/gui2/?type=authors&mode=browse&sel=10005475" target="_blank">Kiss Attila (<span class="authorship-author-name">Kiss Attila</span> <span class="authorAux-mtmt"> Haematológia, belgyógyász</span>) </a> </span> ; <span class="author-name" mtid="10060158"><a href="/gui2/?type=authors&mode=browse&sel=10060158" target="_blank">Tóth Ferenc (<span class="authorship-author-name">Tóth Ferenc</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/Fogorvostudományi Kar; <span title="Debreceni Egyetem">DE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Bioanyagtani és Fogpótlástani nem önálló Tanszék</span> ; <span class="author-name" mtid="10017334"><a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobágyi Tibor ✉ (<span class="authorship-author-name">Hortobágyi Tibor</span> <span class="authorAux-mtmt"> Neuropathológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Pathológiai Intézet; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Neurológiai Tanszék; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/MTA-DE Cerebrovascularis és Neurodegeneratív Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;31618650" target="_blank">Female sex as an independent prognostic factor in the development of oral mucositis during autologous peripheral stem cell transplantation</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">1</span> <span class="page"> Paper 15898. 12 p. </span> <span class="year">(2020)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-020-72592-5" target="_blank" href="https://doi.org/10.1038/s41598-020-72592-5"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000577346400013" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000577346400013"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85091623657" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85091623657"> Scopus </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="22850" target="_blank" href="http://publicatio.bibl.u-szeged.hu/22850"> SZTE Publicatio </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 9 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt: 7 | WoS/Scopus jelölt: 11 | DOI jelölt: 11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;31618650&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 31618650</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">DEENK-PA</span> </div> <div class="lastModified">Utolsó módosítás: 2021.11.12. 11:03 Csonka Petra (SZTE admin5 SZAOK Anatómia) </div> </div></div>
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Immunohistochemical correlates of TP53 somatic mutations in cancer
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Despite controversy on the correlation between p53 accumulation and TP53 mutational status, immunohistochemical (IHC) detection of overexpressed protein has long been used as a surrogate method for mutation analysis. The aim of our study was to characterise the IHC expression features of TP53 somatic mutations and define their occurrence in human cancers. A large-scale database analysis was conducted in the IARC TP53 Database (R17); 7878 mutations with IHC features were retrieved representing 60 distinct tumour sites. The majority of the alterations were immunopositive (p<0.001). Sex was known for 4897 mutations showing a female dominance (57.2%) and females carrying negative mutations were significantly younger. TP53 mutations were divided into three IHC groups according to mutation frequency and IHC positivity. Each group had female dominance. Among the IHC groups, significant correlations were observed with age at diagnosis in breast, bladder, liver, haematopoietic system and head & neck cancers. An increased likelihood of false negative IHC associated with rare nonsense mutations was observed in certain tumour sites. Our study demonstrates that p53 immunopositivity largely correlates with TP53 mutational status but that expression is absent in certain mutation types. Besides, describing the complex IHC expression of TP53 somatic mutations, our results reveal some caveats for the diagnostic practice.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10038233"> <a href="/gui2/?type=authors&mode=browse&sel=10038233" target="_blank">Murnyák, Balázs</a> </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10017334"> <a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobágyi, Tibor</a> </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;3114381" mtid="3114381" target="_blank">Immunohistochemical correlates of TP53 somatic mutations in cancer</a></div> <div class="pub-info"> <span class="journal-title">ONCOTARGET</span> <span class="journal-volume">7</span> <span class="page"> pp. 64910-64920. , 11 p. </span> <span class="year">(2016)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.18632/oncotarget.11912" target="_blank" href="https://doi.org/10.18632/oncotarget.11912"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="230432" target="_blank" href="http://hdl.handle.net/2437/230432"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000387281000029" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000387281000029"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="84994065818" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84994065818"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="27626311" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27626311&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:3114381 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 81</span> | Független: 79 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 81 | Scopus jelölt: 44 | WoS/Scopus jelölt: 81 | DOI jelölt: 79 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10038233"><a href="/gui2/?type=authors&mode=browse&sel=10038233" target="_blank">Murnyák Balázs (<span class="authorship-author-name">Murnyák Balázs</span> <span class="authorAux-mtmt"> Genetika, Onkogenetika</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Pathológiai Intézet</span> ; <span class="author-name" mtid="10017334"><a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobágyi Tibor (<span class="authorship-author-name">Hortobágyi Tibor</span> <span class="authorAux-mtmt"> Neuropathológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Pathológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;3114381" target="_blank">Immunohistochemical correlates of TP53 somatic mutations in cancer</a></div> <div> <span class="journal-title">ONCOTARGET</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1949-2553">1949-2553</a>)</span>: <span class="journal-volume">7</span> <span class="page"> pp 64910-64920 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.18632/oncotarget.11912" target="_blank" href="https://doi.org/10.18632/oncotarget.11912"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="230432" target="_blank" href="http://hdl.handle.net/2437/230432"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000387281000029" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000387281000029"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="84994065818" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84994065818"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="27626311" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27626311&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 81</span> | Független: 79 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 81 | Scopus jelölt: 44 | WoS/Scopus jelölt: 81 | DOI jelölt: 79 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3114381</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3114381</span> | Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2018.12.03. 09:36 Zeller Rozália (SZTE admin5) </div> </div></div>
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Megosztott utolsó szerzőség. (†These authors equally
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Howlett, DR
Clusterin Associates Specifically with Abeta40 in Alzheimer's Disease Brain Tissue
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2013
Genome-wide association studies have pointed to clusterin (apolipoprotein J) as being linked to the occurrence of Alzheimer's disease (AD); studies have identified the protein as a possible biomarker. The association between clusterin and senile plaques in AD brain is well known, and clusterin levels in AD brain are 40% higher than that in control subjects. The present study investigates, immunohistochemically, the association between clusterin and Abeta peptides in AD and control cortex. A unique and specific association between clusterin and Abeta40 was observed in plaques in the cerebral cortex from AD subjects in that only plaques that contained Abeta40 showed clusterin immunoreactivity, while the many plaques with Abeta42 alone lacked clusterin labeling. Cerebrovascular Abeta in AD brain generally lacked Abeta42 but was positively labeled by both the Abeta40 and the clusterin antibodies. In control subjects, however, Abeta40 was absent from plaques, although very occasional plaques were found to be labeled by both the Abeta42 and the clusterin antibodies. Overall, in AD, but not aged control brain, clusterin was associated specifically with the Abeta40 form of Abeta in the brain. The lack of clusterin in association with Abeta42 may be a significant feature in neuronal loss and neurodegeneration in the disease state.
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4HT (Hortobágyi Tibor (Neuropathológia); 2013.05.21. 12:20:45)
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Howlett, DR </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10017334"> <a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobagyi, T<sup>**</sup></a> </span> <span class="author-type"> </span> ; <span class="author-name" > Francis, PT </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2320358" mtid="2320358" target="_blank">Clusterin Associates Specifically with Abeta40 in Alzheimer's Disease Brain Tissue</a></div> <div class="pub-info"> <span class="journal-title">BRAIN PATHOLOGY</span> <span class="journal-volume">23</span> : <span class="journal-issue">6</span> <span class="page"> pp. 623-632. , 10 p. </span> <span class="year">(2013)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1111/bpa.12057" target="_blank" href="https://doi.org/10.1111/bpa.12057"> DOI </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="190463" target="_blank" href="http://hdl.handle.net/2437/190463"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000325608000002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000325608000002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="84885664791" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84885664791"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="23521156" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23521156&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="http://doi.wiley.com/10.1111/bpa.12057" target="_blank" href="http://doi.wiley.com/10.1111/bpa.12057"> Teljes dokumentum </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:2320358 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 25</span> | Független: 24 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 25 | Scopus jelölt: 21 | WoS/Scopus jelölt: 25 | DOI jelölt: 25 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Howlett DR
</span>
;
<span class="author-name" mtid="10017334"><a
href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobagyi T<sup>**</sup>
(<span class="authorship-author-name">Hortobágyi Tibor</span>
<span class="authorAux-mtmt"> Neuropathológia</span>)
</a>
</span>
<span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Pathológiai Intézet</span>
;
<span class="author-name" >Francis PT
</span>
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</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;2320358" target="_blank">Clusterin Associates Specifically with Abeta40 in Alzheimer's Disease Brain Tissue</a></div> <div> <span class="journal-title">BRAIN PATHOLOGY</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1015-6305">1015-6305</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1750-3639">1750-3639</a>)</span>:
<span class="journal-volume">23</span> <span class="journal-issue">6</span>
<span class="page">
pp 623-632
</span> <span class="year">(2013)</span>
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<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 25</span>
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| WoS/Scopus jelölt: 25
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 2320358</span>
| <span class="status-data status-VALIDATED"> Egyeztetett
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<span class="oldId">Régi azonosító: 2320358</span> |
Forrás
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( Szakcikk
)
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<div class="lastModified">Utolsó módosítás: 2018.12.04. 11:36 Zeller Rozália (SZTE admin5)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megosztott utolsó szerzőség. (†These authors equally
contributed to this work as “senior authors”. Tibor Hortobágyi†
and Paul T. Francis†)</pre>
</div></div>
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p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS.
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Neuronal cytoplasmic inclusions (NCIs) containing phosphorylated TDP-43 (p-TDP-43) are the pathological hallmarks of motor neuron disease/amyotrophic lateral sclerosis (MND/ALS) and FTLD-TDP. The vast majority of NCIs in the brain and spinal cord also label for ubiquitin and p62, however, we have previously reported a subset of TDP-43 proteinopathy patients who have unusual and abundant p62 positive, TDP-43 negative inclusions in the cerebellum and hippocampus. Here we sought to determine whether these cases carry the hexanucleotide repeat expansion in C9orf72. Repeat primer PCR was performed in 36 MND/ALS, FTLD-MND/ALS and FTLD-TDP cases and four controls. Fourteen individuals with the repeat expansion were detected. In all the 14 expansion mutation cases there were abundant globular and star-shaped p62 positive NCIs in the pyramidal cell layer of the hippocampus, the vast majority of which were p-TDP-43 negative. p62 positive NCIs were also abundant in the cerebellar granular and molecular layers in all cases and in Purkinje cells in 12/14 cases but they were only positive for p-TDP-43 in the granular layer of one case. Abundant p62 positive, p-TDP-43 negative neuronal intranuclear inclusions (NIIs) were seen in 12/14 cases in the pyramidal cell layer of the hippocampus and in 6/14 cases in the cerebellar granular layer. This unusual combination of inclusions appears pathognomonic for C9orf72 repeat expansion positive MND/ALS and FTLD-TDP which we believe form a pathologically distinct subset of TDP-43 proteinopathies. Our results suggest that proteins other than TDP-43 are binding p62 and aggregating in response to the mutation which may play a mechanistic role in neurodegeneration.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Al-Sarraj, S </span> <span class="author-type"> </span> ; <span class="author-name" > King, A </span> <span class="author-type"> </span> ; <span class="author-name" > Troakes, C </span> <span class="author-type"> </span> ; <span class="author-name" > Smith, B </span> <span class="author-type"> </span> ; <span class="author-name" > Maekawa, S </span> <span class="author-type"> </span> ; <span class="author-name" > Bodi, I </span> <span class="author-type"> </span> ; <span class="author-name" > Rogelj, B </span> <span class="author-type"> </span> ; <span class="author-name" > Al-Chalabi, A </span> <span class="author-type"> </span> ; <span class="author-name" mtid="10017334"> <a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobagyi, T</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Shaw, CE </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;2349791" mtid="2349791" target="_blank">p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS.</a></div> <div class="pub-info"> <span class="journal-title">ACTA NEUROPATHOLOGICA</span> <span class="journal-volume">122</span> : <span class="journal-issue">6</span> <span class="page"> pp. 691-702. , 12 p. </span> <span class="year">(2011)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00401-011-0911-2" target="_blank" href="https://doi.org/10.1007/s00401-011-0911-2"> DOI </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="121339" target="_blank" href="http://hdl.handle.net/2437/121339"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000297471200004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000297471200004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="82355180826" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-82355180826"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="22101323" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22101323&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="http://www.springerlink.com/index/10.1007/s00401-011-0911-2" target="_blank" href="http://www.springerlink.com/index/10.1007/s00401-011-0911-2"> Teljes dokumentum </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:2349791 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 364</span> | Független: 332 | Függő: 32 | Nem jelölt: 0 | WoS jelölt: 346 | Scopus jelölt: 311 | WoS/Scopus jelölt: 364 | DOI jelölt: 360 (Nem nyilvános: 1) </div> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Al-Sarraj S
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<span class="author-name" >King A
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<span class="author-name" >Troakes C
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<span class="author-name" >Smith B
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<span class="author-name" >Maekawa S
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<span class="author-name" >Bodi I
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<span class="author-name" >Rogelj B
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<span class="author-name" >Al-Chalabi A
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<span class="author-name" mtid="10017334"><a
href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobagyi T
(<span class="authorship-author-name">Hortobágyi Tibor</span>
<span class="authorAux-mtmt"> Neuropathológia</span>)
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<span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Pathológiai Intézet</span>
;
<span class="author-name" >Shaw CE
</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;2349791" target="_blank">p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS.</a></div> <div> <span class="journal-title">ACTA NEUROPATHOLOGICA</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0001-6322">0001-6322</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1432-0533">1432-0533</a>)</span>:
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<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 364</span>
| Független: 332
| Függő: 32
| Nem jelölt: 0
| WoS jelölt: 346
| Scopus jelölt: 311
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| DOI jelölt: 360
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 2349791</span>
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<span class="oldId">Régi azonosító: 2349791</span> |
Forrás Idéző
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<div class="lastModified">Utolsó módosítás: 2018.10.11. 09:24 WoS import (admin)
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Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders.
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Optineurin (OPTN) is a multifunctional protein involved in vesicular trafficking, signal transduction and gene expression. OPTN mutations were described in eight Japanese patients with familial and sporadic amyotrophic lateral sclerosis (FALS, SALS). OPTN-positive inclusions co-localising with TDP-43 were described in SALS and in FALS with SOD-1 mutations, potentially linking two pathologically distinct pathways of motor neuron degeneration. We have explored the abundance of OPTN inclusions using a range of antibodies in postmortem tissues from 138 cases and controls including sporadic and familial ALS, frontotemporal lobar degeneration (FTLD) and a wide range of neurodegenerative proteinopathies. OPTN-positive inclusions were uncommon and detected in only 11/32 (34%) of TDP-43-positive SALS spinal cord and 5/15 (33%) of FTLD-TDP. Western blot of lysates from FTLD-TDP frontal cortex and TDP-43-positive SALS spinal cord revealed decreased levels of OPTN protein compared to controls (p < 0.05), however, this correlated with decreased neuronal numbers in the brain. Large OPTN inclusions were not detected in FALS with SOD-1 and FUS mutation, respectively, or in FTLD-FUS cases. OPTN-positive inclusions were identified in a few Alzheimer's disease (AD) cases but did not co-localise with tau and TDP-43. Occasional striatal neurons contained granular cytoplasmic OPTN immunopositivity in Huntington's disease (HD) but were absent in spinocerebellar ataxia type 3. No OPTN inclusions were detected in FTLD-tau and alpha-synucleinopathy. We conclude that OPTN inclusions are relatively rare and largely restricted to a minority of TDP-43 positive ALS and FTLD-TDP cases. Our results do not support the proposition that OPTN inclusions play a central role in the pathogenesis of ALS, FTLD or any other neurodegenerative disorder.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10017334"> <a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobagyi, T</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Troakes, C </span> <span class="author-type"> </span> ; <span class="author-name" > Nishimura, AL </span> <span class="author-type"> </span> ; <span class="author-name" > Vance, C </span> <span class="author-type"> </span> ; <span class="author-name" > van Swieten, JC </span> <span class="author-type"> </span> ; <span class="author-name" > Seelaar, H </span> <span class="author-type"> </span> ; <span class="author-name" > King, A </span> <span class="author-type"> </span> ; <span class="author-name" > Al-Sarraj, S </span> <span class="author-type"> </span> ; <span class="author-name" > Rogelj, B </span> <span class="author-type"> </span> ; <span class="author-name" > Shaw, CE </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1518133" mtid="1518133" target="_blank">Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders.</a></div> <div class="pub-info"> <span class="journal-title">ACTA NEUROPATHOLOGICA</span> <span class="journal-volume">121</span> : <span class="journal-issue">4</span> <span class="page"> pp. 519-527. Paper: 21360076 , 9 p. </span> <span class="year">(2011)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00401-011-0813-3" target="_blank" href="https://doi.org/10.1007/s00401-011-0813-3"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="112424" target="_blank" href="http://hdl.handle.net/2437/112424"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000288446100008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000288446100008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="79954594082" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-79954594082"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="21360076" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21360076&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="http://www.springerlink.com/index/10.1007/s00401-011-0813-3" target="_blank" href="http://www.springerlink.com/index/10.1007/s00401-011-0813-3"> Teljes dokumentum </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1518133 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 69</span> | Független: 60 | Függő: 9 | Nem jelölt: 0 | WoS jelölt: 65 | Scopus jelölt: 64 | WoS/Scopus jelölt: 69 | DOI jelölt: 66 </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10017334"><a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobagyi T (<span class="authorship-author-name">Hortobágyi Tibor</span> <span class="authorAux-mtmt"> Neuropathológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Pathológiai Intézet</span> ; <span class="author-name" >Troakes C </span> ; <span class="author-name" >Nishimura AL </span> ; <span class="author-name" >Vance C </span> ; <span class="author-name" >van Swieten JC </span> ; <span class="author-name" >Seelaar H </span> ; <span class="author-name" >King A </span> ; <span class="author-name" >Al-Sarraj S </span> ; <span class="author-name" >Rogelj B </span> ; <span class="author-name" >Shaw CE </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;1518133" target="_blank">Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders.</a></div> <div> <span class="journal-title">ACTA NEUROPATHOLOGICA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0001-6322">0001-6322</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1432-0533">1432-0533</a>)</span>: <span class="journal-volume">121</span> <span class="journal-issue">4</span> <span class="page"> pp 519-527 Paper 21360076. </span> <span class="year">(2011)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00401-011-0813-3" target="_blank" href="https://doi.org/10.1007/s00401-011-0813-3"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="112424" target="_blank" href="http://hdl.handle.net/2437/112424"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000288446100008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000288446100008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="79954594082" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-79954594082"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="21360076" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21360076&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="http://www.springerlink.com/index/10.1007/s00401-011-0813-3" target="_blank" href="http://www.springerlink.com/index/10.1007/s00401-011-0813-3"> Teljes dokumentum </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 69</span> | Független: 60 | Függő: 9 | Nem jelölt: 0 | WoS jelölt: 65 | Scopus jelölt: 64 | WoS/Scopus jelölt: 69 | DOI jelölt: 66 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;1518133&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1518133</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 1518133</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2022.05.02. 10:32 Pécsi Éva (MTMT Közp 3, admin) </div> </div></div>
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Traumatic axonal damage in the brain can be detected using beta-APP immunohistochemistry within 35 min after head injury to human adults.
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Immunohistochemistry staining for beta-amyloid precursor protein (beta-APP) is a sensitive method to detect early axonal damage in traumatic brain injury, which was previously estimated to be of minimum 60-90 min after head injury. We present seven cases of well-documented posttraumatic survival of 35-60 min where beta-APP detects early axonal damage. Cases were selected from routine work where documentation about survival is judged to be accurate. These are divided into three groups: group 1: severe head injury (n = 7) with documented survival between 35 and 60 min. Group 2: severe head injury (n = 4) with documented survival of less than 30 min. Group 3: cases (n = 4) where death was not due to head injury but survival is documented between 45 and 109 min. The brains were fixed in formalin for 4 weeks and six regions (frontal lobe with anterior corpus callosum, parietal lobe with deep white matter, basal ganglia with posterior limb of internal capsule, cerebellum with white matter and middle cerebellar peduncle and pons with basis pontis and superior cerebellar peduncle) were sampled. All blocks were stained for haematoxylin and eosin and beta-APP and selected ones for CD68, using antigen retrieval method. In group 1 sections revealed beta-APP immunoreactivity in forms of small globules and granules and occasionally as thin and short filaments. These were detected in the pons, corpus callosum, internal capsule and cerebral white matter, with some variation in localization and intensity. In groups 2 and 3 all the sections were negative for beta-APP staining. None of the cases showed evidence of severe brain swelling, increased intracranial pressure, ischaemia or infection. Using the antigen retrieval method, beta-APP immunohistochemistry can detect axonal damage within 35 min after severe head injury. These results may have an implication in the consideration of minimal survival time after traumatic head injury in medico-legal practice.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10017334"> <a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobagyi, T</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Wise, S </span> <span class="author-type"> </span> ; <span class="author-name" > Hunt, N </span> <span class="author-type"> </span> ; <span class="author-name" > Hunt, N </span> <span class="author-type"> </span> ; <span class="author-name" > Cary, N </span> <span class="author-type"> </span> ; <span class="author-name" > Djurovic, V </span> <span class="author-type"> </span> ; <span class="author-name" > Fegan-Earl, A </span> <span class="author-type"> </span> ; <span class="author-name" > Rouse, D </span> <span class="author-type"> </span> ; <span class="author-name" > Al-Sarraj, S </span> <span class="author-type"> </span> ; <span class="author-name" > Rouse, D </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1518171" mtid="1518171" target="_blank">Traumatic axonal damage in the brain can be detected using beta-APP immunohistochemistry within 35 min after head injury to human adults.</a></div> <div class="pub-info"> <span class="journal-title">NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY</span> <span class="journal-volume">33</span> : <span class="journal-issue">2</span> <span class="page"> pp. 226-237. , 12 p. </span> <span class="year">(2007)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1111/j.1365-2990.2006.00794.x" target="_blank" href="https://doi.org/10.1111/j.1365-2990.2006.00794.x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="112507" target="_blank" href="http://hdl.handle.net/2437/112507"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000244776700009" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000244776700009"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33847743484" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-33847743484"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="17359363" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17359363&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="http://doi.wiley.com/10.1111/j.1365-2990.2006.00794.x" target="_blank" href="http://doi.wiley.com/10.1111/j.1365-2990.2006.00794.x"> Teljes dokumentum </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1518171 </span> <span class="status-holder"><span class="status-data status-APPROVED"> Nyilvános </span></span> <span class="pub-core">Forrás </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 92</span> | Független: 86 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 82 | Scopus jelölt: 73 | WoS/Scopus jelölt: 92 | DOI jelölt: 85 (Nem nyilvános: 2) </div> </div> </div> </div><div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10017334"><a href="/gui2/?type=authors&mode=browse&sel=10017334" target="_blank">Hortobagyi T (<span class="authorship-author-name">Hortobágyi Tibor</span> <span class="authorAux-mtmt"> Neuropathológia</span>) </a> </span> ; <span class="author-name" >Wise S </span> ; <span class="author-name" >Hunt N </span> ; <span class="author-name" >Hunt N </span> ; <span class="author-name" >Cary N </span> ; <span class="author-name" >Djurovic V </span> ; <span class="author-name" >Fegan-Earl A </span> ; <span class="author-name" >Rouse D </span> ; <span class="author-name" >Al-Sarraj S </span> ; <span class="author-name" >Rouse D </span> ; <span class="author-name" >Al-Sarraj S </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse¶ms=publication;1518171" target="_blank">Traumatic axonal damage in the brain can be detected using beta-APP immunohistochemistry within 35 min after head injury to human adults.</a></div> <div> <span class="journal-title">NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0305-1846">0305-1846</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1365-2990">1365-2990</a>)</span>: <span class="journal-volume">33</span> <span class="journal-issue">2</span> <span class="page"> pp 226-237 </span> <span class="year">(2007)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1111/j.1365-2990.2006.00794.x" target="_blank" href="https://doi.org/10.1111/j.1365-2990.2006.00794.x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="112507" target="_blank" href="http://hdl.handle.net/2437/112507"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000244776700009" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000244776700009"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="33847743484" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-33847743484"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="17359363" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17359363&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="http://doi.wiley.com/10.1111/j.1365-2990.2006.00794.x" target="_blank" href="http://doi.wiley.com/10.1111/j.1365-2990.2006.00794.x"> Teljes dokumentum </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 92</span> | Független: 86 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 82 | Scopus jelölt: 73 | WoS/Scopus jelölt: 92 | DOI jelölt: 85 (Nem nyilvános: 2) </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1518171</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 1518171</span> | Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2022.05.02. 20:18 Pécsi Éva (MTMT Közp 3, admin) </div> </div></div>