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However, it is unclear whether epidermal keratinocytes are involved in disease recurrence. There is increasing evidence regarding the importance of epigenetic mechanisms in the pathogenesis of psoriasis. Nonetheless, the epigenetic changes that contribute to the recurrence of psoriasis remain unknown. The aim of this study was to elucidate the role of keratinocytes in psoriasis relapse. The epigenetic marks 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) were visualized using immunofluorescence staining, and RNA sequencing was performed on paired never-lesional and resolved epidermal and dermal compartments of skin from psoriasis patients. We observed diminished 5-mC and 5-hmC amounts and decreased mRNA expression of the ten-eleven translocation (TET) 3 enzyme in the resolved epidermis. SAMHD1, C10orf99, and AKR1B10: the highly dysregulated genes in resolved epidermis are known to be associated with pathogenesis of psoriasis, and the DRTP was enriched in WNT, TNF, and mTOR signaling pathways. Our results suggest that epigenetic changes detected in epidermal keratinocytes of resolved skin may be responsible for the DRTP in the same regions. Thus, the DRTP of keratinocytes may contribute to site-specific local relapse.", "digital" : true, "printed" : null, "sourceYear" : 2023, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "GOLD", "oaCheckDate" : "2024-02-22", "oaFree" : true, "oaLink" : "https://doi.org/10.3390/ijms24054556", "citationCount" : 5, "citationCountUnpublished" : 0, "citationCountWoOther" : 5, "independentCitCountWoOther" : 4, "nationalOriginCitationCount" : 1, "foreignEditionCitationCount" : 5, "doiCitationCount" : 5, "wosCitationCount" : 4, "scopusCitationCount" : 5, "wosScopusCitationCount" : 5, "wosScopusCitationCountWoOther" : 5, "wosScopusIndependentCitationCount" : 4, "wosScopusIndependentCitationCountWoOther" : 4, "independentCitationCount" : 4, "selfCitationCount" : 1, "unhandledCitationCount" : 0, "citingPubCount" : 5, "independentCitingPubCount" : 4, "citingPubCountWoOther" : 5, "independentCitingPubCountWoOther" : 4, "unhandledCitingPubCount" : 0, "citedPubCount" : 7, "citedCount" : 7, "ratings" : [ { "otype" : "SjrRating", "mtid" : 11388418, "link" : "/api/sjrrating/11388418", "label" : "sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067", "listPos" : 7, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 1604, "link" : "/api/classificationexternal/1604", "label" : "Scopus - Inorganic Chemistry", "published" : true, "oldId" : 1604, "snippet" : true }, "ranking" : "D1", "calculation" : "FROM_LAST_YEAR", "published" : true, "snippet" : true } ], "ratingsForSort" : "D1", "hasCitationDuplums" : false, "inSelectedPubs" : "10001275,10012968,10055274", "userChangeableUntil" : "2023-05-30T07:04:21.476+0000", "directInstitutesForSort" : "Biokémiai Intézet (HRN SZBK); Biokémiai és Molekuláris Biológiai Intézet (DE / ÁOK); Bőrgyógyászati és Allergológiai Klinika (SZTE / SZAOK); ELKH-SZTE Dermatológiai Kutatócsoport (SZTE / SZAOK / BAK); Növénybiológiai Intézet (HRN SZBK)", "ownerAuthorCount" : 12, "ownerInstituteCount" : 33, "directInstituteCount" : 5, "authorCount" : 12, "contributorCount" : 0, "hasQualityFactor" : true, "tempLockerIds" : [ 10003133 ], "link" : "/api/publication/33674092", "label" : "Ghaffarinia Ameneh et al. Psoriatic Resolved Skin Epidermal Keratinocytes Retain Disease-Residual Transcriptomic and Epigenomic Profiles. (2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 5", "template" : "